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产前诊断误诊带来5000万美金的罚款,震撼业界!
2000年,Rhea和Brock结为夫妇,并在2002年生育了一个可爱的儿子。Brock的表妹在接受基因检测后被诊断出患有2号和9号染色体非平衡易位,这位表妹患有严重的癫痫病,具有反社会倾向,身材肥胖并且只能坐在轮椅上。得知表妹的情...
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科学家研制“爱情香水”可通过体味吸引异性
...侣的。剑桥大学的动物学家蒂姆?克拉顿?布罗克(TimClutton-Brock)和哈佛大学的研究者凯瑟琳?麦考利夫(KatherineMcAuliffe)发现,嗅觉线索在雌性寻找配偶的过程中十分关键。 虽然和鸟类一样,人类也会精心打扮、高视阔步,有时也...
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AssessingtheSerodiagnosticPotentialof35MycobacteriumtuberculosisProteinsandIdentificationofFourNovelSerologicalAntigens
...ecimenbankforprovidingtheserumsamplescollectedinUganda.AxelKok-Jensen,IngerBrock,andPernilleRavnarethankedfortheireffortswiththecollectionofserumsamplesinDenmark,andPatriciaGrenesandJetteFljborgarethankedfortheirvaluabletechnicalassistance.M.Singhisthankedforprovidingthe38-kDaantigenforthisstudy.Kar...
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MultiplexPCR-IdentifiedCutaneousTuberculosisEvokedbyMycobacteriumbovisBCGVaccinationinaHealthyBaby
...berculosiscomplex.J.Clin.Microbiol.36:2471-2476.Murphy,P.D.,D.L.Mayers,N.F.Brock,andK.F.Wagner.1989CureofbacilleCalmette-Guerinvaccinationabscesswitherythromycin.Rev.Infect.Dis.11:335-337.Singh,G.,andM.Singh.1984.ErythromycinforBCGcoldabscess.Lancetii:979.Talbot,E.A.,M.D.Perkins,S.F.Silva,andR.Froth...
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主动脉瓣膜部狭窄
...病变瓣膜,作人工主动脉瓣膜替换术。1952年Bailey和1954年Brock经左心室心尖部小切口,放入特制的主动脉瓣膜扩张器扩张分离融合的主动脉瓣叶交界。但因瓣膜扩张不彻底,又易引致关闭不全,疗效欠满意,乃逐渐被直视手术所...
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PeritonitisDuetoCurvulariainaequalisinanElderlyPatientUndergoingPeritonealDialysisandaReviewofSixCasesofPeritonitisAssociatedwithOtherC
...s.Clin.Infect.Dis.36:927-931.Brackett,R.W.,A.N.Shenouda,S.S.Hawkins,andW.B.Brock.1988.Curvulariainfectioncomplicatingperitonealdialysis.South.Med.J.81:943-944.Canon,H.L.,S.C.Buckingham,R.J.Wyatt,andD.P.Jones.2001.FungalperitonitiscausedbyCurvulariaspeciesinachildundergoingperitonealdialysis.Pediatr....
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颅脑外伤致精神障碍机制研究
...所致,其机制较为复杂,特别是脑外伤后并发的许多延迟的综合征(post-traumaticbrainsyndrome)。随着影像学技术的不断发展以及对于计算机体层摄影(CT)和磁共振成像(MRI)检查有关内容的解释,极大地提高了我们处理头外伤及其并发...
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UtilityoftheAustralianNationalSubacuteandNonacutePatientCasemixClassification
...showedthegreatestimprovementbecausetheyhavethegreatestpotentialtorecover.12Brock13arguesthatpatientswithhigherinitialfunctionmightactuallyshowmoreimprovementonatoolliketheFIMbecausetheimprovementismoredifficulttoachieveandtheFIMscorelevelsarenotinterval.However,whenconsideredintermsofburdenofcare,th...
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GenomicApproachtoIdentificationofMycobacteriumbovisDiagnosticAntigensinCattle
...icrobialpathogens.Mol.Microbiol.33:1103-1117.Krebs,J.,R.Anderson,T.Clutton-Brock,I.Morrison,D.Young,andC.Donnely.1997.Bovinetuberculosisincattleandbadgers:reporttotheRt.Hon.Dr.JackCunninghamMP.MAFFPublications,London,UK.Lewin,H.A.,G.C.Russell,andE.J.Glass.1999.Comparativeorganizationandfunctionofthe...
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ReproducibilityofLowGalactomannanEnzymeImmunoassayIndexValuesTestedinMultipleLaboratories
...trecipients.Br.J.Haematol.126:852-860.Maertens,J.,J.Verhaegen,H.Demuynck,P.Brock,G.Verhoff,P.Vandenberghe,J.V.Eldere,L.Verbist,andM.Boogaerts.1999.Autopsy-controlledprospectiveevaluationofserialscreeningforcirculatinggalactomannanbyasandwichenzyme-linkedimmunosorbentassayforhematologicalpatientsatri...
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转化生长因子-α、血管内皮生长因子与皮肤肿瘤
...血管内皮细胞膜上的两种亚型酪氨酸激酶受体Flt-1和KDR。Brock等研究发现[11],VEGF与受体结合后细胞内短暂Ca2+浓度升高,微摩尔浓度的VEGF在几秒内就可使Ca2+升高数倍。VEGF对内皮细胞的作用类似内皮细胞激动剂如凝血酶和组织...
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UseofReal-TimePCRToProcesstheFirstGalactomannan-PositiveSerumSampleinDiagnosingInvasiveAspergillosis
...recipients.J.Infect.Dis.186:1297-1306.Maertens,J.,J.Verhaegen,H.Demuynck,P.Brock,G.Verhoef,P.Vandenberghe,J.VanEldere,L.Verbist,andM.Boogaerts.1999.Autopsy-controlledprospectiveevaluationofserialscreeningforcirculatinggalactomannanbyasandwichenzyme-linkedimmunosorbentassayforhematologicalpatientsatr...
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Adoptivetransferofcytomegalovirus-specificCTLtostemcelltransplantpatientsafterselectionbyHLA–peptidetetramers
...allogeneicstemcelltransplantation.Blood.97:1232–1240.Kern,F.,I.P.Surel,C.Brock,B.Freistedt,H.Radtke,A.Scheffold,R.Blasczyk,P.Reinke,J.Schneider-Mergener,A.Radbruch,P.WaldenandH.D.Volk.1998.T-cellepitopemappingbyflowcytometry.Nat.Med.4:975–978.Szmania,S.,A.Galloway,M.Bruorton,P.Musk,G.Aubert,A.Ar...
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第四节 影响PCR的主要因素
...温菌(Thermusaquatics)YT1蓖株中分离而得。此菌于1969年由Brock分离自美国黄石公园温泉,作为栖热杆菌的标准菌株,其生长温度为70~75℃。最初从中分离到分子量60~68KDa,比活性为2000~8000U/mg的DNA聚合酶。后来Cetus公司的KaryMullis...
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SystemToAssessGenomeSequencingNeedsforViralProteinDiagnosticsandTherapeutics
...evelopmentofaHIV-1gp41-directedvaccine.Curr.HIVRes.2:193-204.Okkels,L.M.,I.Brock,F.Follmann,E.M.Agger,S.M.Arend,T.H.Ottenhoff,F.Oftung,I.Rosenkrands,andP.Andersen.2003.PPEprotein(Rv3873)fromDNAsegmentRD1ofMycobacteriumtuberculosis:strongrecognitionofbothspecificT-cellepitopesandepitopesconservedwith...
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Disruptionofrenalperitubularbloodflowinlipopolysaccharide-inducedrenalfailure:roleofnitricoxideandcaspases
...nthepathogenesisofacuterenalfailure.CurrOpinNephrolHypertens11:301308,2002.BrockRW,CarsonMW,HarrisKA,andPotterRF.Microcirculatoryperfusiondeficitsarenotessentialforremoteparenchymalinjurywithintheliver.AmJPhysiolGastrointestLiverPhysiol277:G55G60,1999.BrownGCandBorutaiteV.Nitricoxideinhibitionofmito...
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UseofanElectronicNoseToDiagnoseMycobacteriumbovisInfectioninBadgersandCattle
...softuberculosisinbadgers.Vet.Rec.153:403-404.Krebs,J.,R.Anderson,T.Clutton-Brock,I.Morrison,D.Young,andC.Donnelly.1997.Bovinetuberculosisincattleandbadgers—reportbytheIndependentScientificReviewGroup.MinistryofAgriculture,FisheriesandFood,London,UnitedKingdom.Lai,S.Y.,O.F.Deffenderfer,W.Hanson,M.P...
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低温停循环与神经元凋亡
...循环会带来不可避免的脑损伤,NO在其中有重要的作用。Brock等使用L-[14C]-精氨酸作为NO生成的指标对狗进行实验,证明低温停循环导致nNOS早期、明显的表达,使脑内NO广泛增多;用细胞免疫化学方法标记NOS特异的单克隆抗...
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Contributionof(13)--D-GlucanChromogenicAssaytoDiagnosisandTherapeuticMonitoringofInvasiveAspergillosisinNeutropenicAdultPatients:aComparison
...recipients.J.Infect.Dis.186:1297-1306.Maertens,J.,J.Verhaegen,H.Demuynck,P.Brock,G.Verhoef,P.Vandenberghe,J.VanEldere,L.Verbist,andM.Boogaerts.1999.Autopsy-controlledprospectiveevaluationofserialscreeningforcirculatinggalactomannanbyasandwichenzyme-linkedimmunosorbentassayforhematologicalpatientsatr...
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DetectionofAspergillusGalactomannanAntigenemiaToDetermineBiologicalandClinicalImplicationsofBeta-LactamTreatments
...pectivevalidation.Blood97:1604-1610.Maertens,J.J.,J.Verhaegan,H.Demuynck,P.Brock,G.Verhoef,P.Vandenberghe,J.VanEldere,L.Verbist,andM.Boogaerts.1999.Autopsy-controlledprospectiveevaluationofserialscreeningforcirculatinggalactomannanbyasandwichenzyme-linkedimmunosorbentassayforhematologicalpatientsatr...
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RecurrentColonizationofSuccessivelyImplantedTracheoesophagealVocalProsthesesbyaMemberoftheFusariumsolaniSpeciesComplex
...therDNA-ITSregion.Mycol.Res.104:1175-1183.Sugiura,Y.,J.R.Barr,D.B.Barr,J.W.Brock,C.M.Elie,Y.Ueno,D.G.Patterson,M.E.Potter,andE.Reiss.1999.PhysiologicalcharacteristicsandmycotoxinsofhumanclinicalisolatesofFusariumspecies.Mycol.Res.103:1462-1468.Summerbell,R.C.2003.Aspergillus,Fusarium,Sporothrix,Pied...
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法乐四联症
...早期可能发生的并发症有出血、房室传导阻滞、低心排血综合征、心力衰竭、肺间质及肺泡水肿引致呼吸衰竭等。【病因学】1970年VanPraagh等认为四联症的胚胎发育障碍是由于肺动脉圆锥远段或右心室漏斗部发育不全,未发生反...
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风湿性二尖瓣狭窄
...径用手指分离扩大二尖瓣瓣口。1947~1948年Harken,Bailey,BroCk等先后经左心耳行闭式二尖瓣交界扩张分离术,疗效良好。1954年Neptune和Bailey又报道经右胸房间沟切口施行二尖瓣交界分离术。这个手术途径可避免术中手指触动左心耳...
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IdentificationofDifferentialProteinExpressionAssociatedwithDevelopmentofUnstableHumanCarotidPlaques
...riosclerThrombVascBiol2003,23:2165-2171DelMaschioA,DeLuigiA,Martin-PaduraI,Brock-hausM,BartfaiT,FruscellaP,AdoriniL,MartinoG,FurlanR,DeSimoniMG,DejanaE:Leukocyterecruitmentinthecerebrospinalfluidofmicewithexperimentalmeningitisisinhibitedbyanantibodytojunctionaladhesionmolecule(JAM).JExpMed1999,190:...
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UseofrMPB70ProteinandESAT-6PeptideasAntigensforComparisonoftheEnzyme-LinkedImmunosorbent,Immunochromatographic,andLatexBeadAgglutinationAs
...J.Vet.Microbiol.78:111-117.Skjot,R.L.V.,T.Oettinger,I.Rosenkrands,P.Ravn,I.Brock,S.Jacobsen,andP.Andersen.2000.Comparativeevaluationoflow-molecular-massproteinsfromMycobacteriumtuberculosisidentifiesmembersoftheESAT-6familyasimmunodominantT-cellantigens.Infect.Immun.68:214-220.Sorensen,A.L.,S.Nagai,...
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常见综合征外治独特新疗法——内病外治·外病外治独特新疗法丛书
...外治·外病外治独特新疗法丛书》之分册。主要阐述常见综合征外治独特新疗法。共分上、中、下篇。上篇为总论;中篇为各论;下篇为常见综合征外治药物高效验方选萃。本书有较强地实用性,可供中医、中西医结合临床医生...
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颅脑综合征的CT、MRI诊断
...0版次:1a内容提要:本书收集临床罕见的涉及颅脑的167个综合征,分别介绍其病因、病理、临床表现、CT和MRI诊断,旨在使放射科医师熟悉掌握各综合征的临床特征、CT和MRI表现及其病理基础,拓宽诊断思路,提高影像诊断水平...
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南方沿海地区围产儿胎儿水肿综合征筛查分析
【摘要】的了解钦州市48738例围产儿胎儿水肿综合征相关因素。方法对钦州市12家出生缺陷监测医院48738例住院分娩的孕满28周至产后7d内的围产儿进行监测。结果胎儿水肿综合征359例,胎儿水肿综合征发生率73.66/万;每年的胎儿...
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HELLP综合征13例临床分析
【摘要】目的分析13例HELLP综合征临床特点,探讨该病的诊断和治疗方法。方法对云南省昆明市及云南省宣威市部分医院2007年1月-2009年1月发生的13例HELLP综合征患者的临床资料进行回顾性分析。结果13例HELLP综合征发病孕周为28~39...
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Brugada综合征及其相关疾病研究进展
...图特点。基于此,他们概括了一种新的、后被称为Brugada综合征的“独特的临床和心电图综合征”。 据估计,在一些国家的所有特发性心室颤动(VF)病例中,与这种心电图特征相联系的VF高达40%~60%。现已明确,“心脏组织...