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Chemical-BasedTranslationalInductionofLuciferaseExpression:AnEfficientToolforinVivoScreeningofProteinFarnesylationInhibitors
...onate(mevalolactone),andtamoxifenwerefromSigma-Aldrich(St.Louis,MO);ICI182,780wasfromTocrisCooksonInc.(Bristol,UK);PBPEwassynthesizedinourlab(Poirotetal.,2000);andestradiolwasfromSteraloids(London,UK).TransientTransfectionsandTreatments.G418selectedclones(producingR17-eIF-4G-CVLS)weretransientlytran...
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EstrogenReceptorAntagonistFulvestrant(ICI182,780)InhibitstheAnti-InflammatoryEffectofGlucocorticoids
...-inducedpleurisy).Inparticular,wehaveinvestigatedwhetherfulvestrant(ICI182,780),aselectiveER-antagonist,isabletoattenuatethewellknownanti-inflammatoryeffectofdexamethasone(DEX),asyntheticglucocorticoid,inovariectomizedrats.WeshowthatICI182,780,aselectiveER-antagonist,reversestheanti-inflammatoryacti...
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DelayofPostnatalMaturationSensitizestheMouseProstatetoTestosterone-InducedPronouncedHyperplasia
...on,andtreatmentswithinhibitorsofestrogenaction,aromataseinhibitor,andICI182780furtherexacerbatedtestosterone-inducedhyperplasticgrowth.However,theactivationofestrogenreceptor(ER)-ßwithaspecificagonist,DPN,preventedthedevelopmentofprostatichyperplasiaandinflammationintestosterone-treatedLuRKOmi...
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TheAntiestrogenTamoxifenActivatesBKChannelsandStimulatesProliferationofMCF-7BreastCancerCells
...ordedinthepresenceoftheselectiveestrogenreceptorantagonistfaslodex(ICI-182,780;1µM).Atthesingle-channellevel,tamoxifensignificantlyincreasedtheopenprobabilityoftheBKchannelby46.2±10.1%(n=4)withoutchangingitsunitaryconductance.Moreover,weshowherethatthestimulationofBKchannelactivitybytam...
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NeuroprotectiveEffectsof17-EstradiolandNonfeminizingEstrogensagainstH2O2ToxicityinHumanNeuroblastomaSK-N-SHCells
...againstH2O2insult.Moreover,theestrogenreceptorantagonistfulvestrant(ICI182,780)didnotblockeffectsof17-E2,butincreasedcellsurvivalandbluntedintracellularCa2+increases.However,theseestrogensfailedtoreducecytosolicreactiveoxygenspecies,evenatconcentrationsashighas10µM.Inconclusion,estrogensexertp...
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报告称转基因作物可促进农业持续、有利且高速发展
...相当于从大气层中减少了177亿kg的二氧化碳,或者相当于780万量汽车一年的排放量。 减少杀虫剂的使用(1996-2009)总量为3.93亿kg(-8.7%),从而也降低了除草剂和杀虫剂对环境的影响,与非转基因相比,转基因作物使用量减...
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LimitedRedundancyinPhosphorylationofRetinoblastomaTumorSuppressorProteinbyCyclin-DependentKinasesinAcuteLymphoblasticLeukemia
...erredserine612,whichwasinhibitedbyp16INK4a,andfascaplysin.Incontrast,serine780andserine795wereefficientlyphosphorylatedbyCDK4butnotbyCDK2.Thedatasuggestthattheredun-dancyinphosphorylationofRBbyCDK2andCDK4inNalm-6extractsislimited.Serine612phosphorylationbyCDK4alsooccurredinextractsofchildhoodacutely...
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慢性非结石性胆囊炎780例超声诊断
...、高热、黄疸[1],易误诊。笔者就近一年来超声检查780例慢性胆囊炎病例资料总结如下。1资料与方法1.1一般资料本组患者共780例,男465例,女315例,年龄30~75岁。1.2仪器与方法应用PHILIPS彩超诊断仪,探头频率12~3MHz。嘱受...
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2008年欧盟生物柴油产量为780万吨
据欧洲生物燃料局表示,2008年欧盟生产了780万吨生物柴油,远远高于2007年的570万吨。 德国产量为280万吨,低于2007年的290万吨。法国180万吨,高于2007年的87.2万吨。意大利59.5万吨,高于07年的36.3万吨。比利时27.7万吨,高于07...
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780例受血者输血前传染性指标检测的临床意义
...指标检测的临床意义。方法采用酶联免疫吸附(ELISA)法对780例输血前患者进行乙型肝炎表面抗原(HBsAg)、丙型肝炎病毒抗体(抗-HCV)、艾滋病病毒抗体(抗-HIV)检测,用梅毒血清学(TRUST)法检测梅毒抗体。结果780例受血者中HBsAg的阳性...
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2019年全球生物塑料产能有望达到约780万吨
...将在2014年170余万吨的基础上增长360%,至2019年有望达到约780万吨。该协会与德国研究机构IfBB和诺瓦研究院合作编辑的数据表明,生物基聚乙烯和生物基聚对苯二甲酸乙二酯将成为这一增长的主要动力。IfBB即德国汉诺威应用科学...
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金嗓灵系列治疗780例声嘶疗效观察
...的观察金嗓灵系列治疗声嘶的结果,探讨其机制。方法对780例声嘶患者,其中资料完整320例,分别用金嗓灵系列(治疗组)和玄甘合剂(对照组)进行治疗并做疗效对比。结果金嗓灵系列有效率95%,玄甘合剂有效率79%。结论金嗓...
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RaloxifenerelaxesratintrarenalarteriesbyinhibitingCa2+influx
...nitro-L-argininemethylester,charybdotoxinplusapamin,indomethacin,orICI-182,780didnotmodifytheeffectofraloxifene.RaloxifenecausedsimilarrelaxationsinringscontractedbyU-46619andhighK+.Nifedipineattenuatedthepotencyofraloxifene.RaloxifenereducedCaCl2-inducedcontractions.K+(80mM)stimulatedanincreaseinVS...
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经导管射频消融治疗780例室上性心动过速的护理
...治疗室上性心动过速(SVT)的临床护理。方法回顾性分析780例室上性心动过速患者RFCA治疗及护理的资料。结果消融成功率:房室折返性心动过速(AVRT)97.5%,房室结内折返性心动过速(AVNRT)96.7%,预激综合征100%。消除320例患者...
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GinsenosideRe,aMainPhytosterolofPanaxginseng,ActivatesCardiacPotassiumChannelsviaaNongenomicPathwayofSexHormones
...igma-Aldrich;SH-6andPP2werepurchasedfromMerck(Darmstadt,Germany),andICI182,780andnilutamidewerepurchasedfromTocris(Ellisville,MO).StocksolutionsofE2(5mM),DHT(5mM),andmifepristone(10mM)werepreparedinethanol;thoseforE-4031(5mM),SMTC(5mM),andL-NIO(1mM)indistilledwater;andthosefornisoldipine(10mM),SH-6(...
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青少年心理健康知晓率780例调查研究
...学高一、高二两个年级及淞谊中学初一、初二两个年级共780例中学生统一采用青少年心理健康知识知晓率调查问卷进行调查,问卷共20项。当场发放当场回收,对所有数据输入电脑进行相关数理统计分析。结果青少年对心理卫生...
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AgonistsofToll-likeReceptors2and4ActivateAirwaySmoothMuscleviaMononuclearLeukocytes
...valofeosinophilsinresponsetolipopolysaccharide.AmJRespirCellMolBiol2000;23:780eC787.MacKenzieA,WilsonHL,Kiss-TothE,DowerSK,NorthRA,SurprenantA.Rapidsecretionofinterleukin-1betabymicrovesicleshedding.Immunity2001;15:825eC835.MorathS,StadelmaierA,GeyerA,SchmidtRR,HartungT.Syntheticlipoteichoicacidfrom...
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TamoxifenandRaloxifeneDifferinTheirFunctionalInteractionswithAspartate351ofEstrogenReceptor
...lagonists,haveashortersidechainthanthefullantiestrogensICI164,384andICI182,780.Tamoxifenandraloxifeneareestrogenagonistsinbone,andtamoxifenbutnotraloxifeneisestrogenicintheuterusofovariectomizedratsormice(Greseetal.,1997).BothSERMscontainalkylaminoethoxysidechains,withdifferenttertiaryaminesubstitue...
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腹部手术后早期机械性肠梗阻的中西医结合治疗(附780例临床报告)
...1982年1月~2005年1月间,共收治腹部手术后机械性肠梗阻780例。现将1982~1990年和1991~2005年两个时期单纯西医治疗和中西医结合治疗结果进行比较,就其治疗体会提出一点看法。 1资料与方法 1.1一般资料术后3周内发生的...
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静脉抽血患者穿刺点护理行为的调查
...者对穿刺点护理知识的了解情况。方法采用问卷调查法对780例医院静脉抽血患者进行调查。结果患者对血管的保护意识差,缺乏对穿刺点的护理知识,主要集中在按压时间、按压方法上。结论护理人员应加强对医院患者的健康教...
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EstrogensCross-Talkto1b-AdrenergicReceptors
...takingplaceduring15min)andwereblockedbytheestrogenreceptorantagonistICI182,780(faslodex).Likewise,inhibitorsofphosphoinositide3-kinase[wortmanninand2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one(LY294002)]andofproteinkinaseC[staurosporine,3-[1-[3-(amidinothio)propyl-1H-indol-3-yl]-3-(1-methyl-1H-i...
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EstrogenIncreasesMitochondrialEfficiencyandReducesOxidativeStressinCerebralBloodVessels
...mec.Thiseffectwasblockedbytheestrogenreceptorantagonistfulvestrant(ICI-182,780,Faslodex)butwasunaffectedbyinhibitorsofnitric-oxidesynthaseorphosphoinositide-3-kinase.Nuclearrespiratoryfactor-1protein,aprimaryregulatorofnucleargene-encodedmitochondrialgenes,wassignificantlyincreasedbylong-termestroge...
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Randomizedcontrolledsafetyandefficacytrialof2vitaminAsupplementationschedulesinTanzanianinfants
...atthesametimeasroutinevaccinationininfantsaged13mo.Design:Werecruited780newborninfantsandtheirmotherstoarandomizeddouble-blindcontrolledtrialinIfakarainsouthernTanzania.Inonegroup,mothersreceived60000µgvitaminApalmitateshortlyafterdelivery,andtheirinfantsreceived7500µgatthesametimeas...
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尿激酶静脉溶栓治疗急性心肌梗死纤溶系统的变化及临床意义
...。方法观察32例首次急性心肌梗死(AMI)患者的尿激酶(UK)静脉溶栓治疗前后血浆UK抗原、组织纤溶酶原激活物(t-PA)抗原、纤溶酶原激活物(PA)活性、纤溶酶原激活物抑制物(PAI)活性、纤溶酶活性和纤维蛋白原抗原的变化...
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Caseselectioninmacularrelocationsurgeryforagerelatedmaculardegeneration
...8:1499.BlandJM,AltmanDG.Someexamplesofregressiontowardsthemean.BMJ1994;309:780.BlandJM,AltmanDG.Statisticalmethodsforassessingagreementbetweentwomethodsofclinicalmeasurement.Lancet1986;1:307–10.MachemerR,SteinhorstUH.Retinalseparation,retinotomy,andmacularrelocation:II.Asurgicalapproachforage-rela...
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EstrogenReducesAngiotensinII–InducedNitricOxideSynthaseandNAD(P)HOxidaseExpressioninEndothelialCells
...fectsofE2ontheAIIresponseswerenotinhibitedbytheE2receptorantagonistICI-182,780.Conclusions—AIIstimulationofendothelialcellsincreasesexpressionofNAD(P)HoxidaseandNOS,whichmaycontributetooxidativestress,asevidencedbyperoxynitriteformation.E2inhibitstheseAIIeffects,possiblythroughreducedAT1Rexpressio...
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Tissueoxygenandhemodynamicsinrenalmedulla,cortex,andcorticomedullaryjunctionduringhemorrhage-reperfusion
...bsolutevalue.Low-energy(2mW)laserlightfromasolid-statediodelaseroperatingat780nm(withinthevisibleredlightspectrum)isguidedtothemeasurementsiteviaanopticalfiber.Anidenticaladjacentfiberreceivestheback-scatteredlightfromthetissueandtransmitsittotwoindependentphotodetectors.Opticalmixingoflightscattere...
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医护人员专业资格和缩写Medicalqualificationabbreviations
...学院院士FBCOFellowofBritishCollegeofOphthalmicOpticians(Optometrists)(UK)英国视光师学院院士FBOAFellowofBritishOpticalAssociation(UK)英国视觉协会院士FChSFellowofSocietyofChiropodists(UK)手足病医生协会院士FCOphthFellow,CollegeofOpthalmologistsofHongKong香港眼科医学...
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Erlotinib,anEffectiveEpidermalGrowthFactorReceptorTyrosineKinaseInhibitor,Inducesp27KIP1Up-RegulationandNuclearTranslocationinAssociationwit
...echnology),monoclonalantibodytoRb,andpolyclonalantibodiestop-RbSer795andSer780(CellSignalingTechnology,Danvers,MA),monoclonalantibodiestoE2F1(KH95;CellSignalingTechnology),andpolyclonalantibodiestoSKP2,p-p27KIP1Thr178(SantaCruzBiotechnology),polyclonalanti-Sp1antibody(PEP-2;SantaCruzBiotechnology),p...
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扶复康口服液的毒性研究
...死亡。用孙瑞亢法测得LD50及其(P=0.95)可信限为(7504.0±780.0)mg/kg。结论扶复康正常剂量无毒性反应。 【关键词】扶复康;小鼠急性毒性实验 扶复康口服液是由复方中药提取的一种新的抗癌针剂,经初步临床观察,该药...