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从临床试验到JNC7
...nicalTrialsin“UncomplicatedHypertension”thatInformJNC7HOT-Hanssonetal.,Lancet1998:351:1755OptimalBP140/90mmHgFelodipinebasedtrialHOTStudy:RiskofaMajorCVEventReducedby30%(DBP)10095908085AchievedDBP(mmHg)OptimalDBPreductionHanssonLetal.Lancet.1998;351:1755-1762PercentriskreductioninmajorCVevents**...
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Lessonsfromthestoryofn-3fattyacids
...farcussenilisandtheirliabilitytoepistaxis.HisviewsweresetoutinalonglettertoLancetin1956,“Deficiencyofessentialfattyacidsandatherosclerosis,etcetera“(1).DanishinvestigatorsBangandDyerberg(2,3)investigatedtherarityofischemicheartdiseaseinGreenlandEskimosandattributedthistotheirmarinediet.Theyshowe...
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TheRiskandBenefitofEndarterectomyinWomenWithSymptomaticInternalCarotidArteryDisease
...NeurolNeurosurgPsychiatry.1988;51:1373–1380.BonitaR.Epidemiologyofstroke.Lancet.1992;339:342–344.WengerNK,SperoffL,PackardB.Cardiovascularhealthanddiseaseinwomen.NEnglJMed.1993;329:247–256.MoscaL,MansonJE,SutherlandSE,LangerRD,ManolioT,Barrett-ConnorE.Cardiovasculardiseaseinwomen:astatementfor...
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ToolittlevitaminDinpremenopausalwomen:whyshouldwecare?
...2530.MalabananA,VeronikisIE,HolickMF.RedefiningvitaminDinsufficiency.Lancet1998;351:8056.GlerupH,MikkelsenK,PoulsenL,etal.CommonlyrecommendeddailyintakeofvitaminDisnotsufficientifsunlightexposureislimited.JInternMed2000;66:41924.GarlandCF,ComstockGW,GarlandFC,HelsingKJ,ShawEK,Gorha...
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EvidenceThatInterferon-PlaysaProtectiveRoleduringCerebralMalaria
...atalcerebral,non-fatalcerebral,anduncomplicatedPlasmodiumfalciparummalaria.Lancet1990;336:12014.Firstcitationinarticle7.PerkinsDJ,WeinbergJB,KremsnerPG.Reducedinterleukin-12andtransforminggrowthfactor1inseverechildhoodmalaria:relationshipofcytokinebalancewithdiseaseseverity.JInfectDis2000;182:98892....
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ReplytoWJMcCarthy
...eoftheseissueswerediscussedpreviouslyinaletterbyMcCarthy(1)totheEditorofTheLancetandintheresponsetoMcCarthybySjöströmetal(2).WeagreewithMcCarthy‘scommentsthatdietaryfatspecificallyisanappropriatetargetinobesitymanagement,inadditiontototalenergyintake,andthatthegutmaybeanimportanttargetof...
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Undernutritionasanunderlyingcauseofchilddeathsassociatedwithdiarrhea,pneumonia,malaria,andmeasles
...inearlyinfancy.WHO/CHDimmunization-linkedvitaminAsupplementationstudygroup.Lancet1998;352:125763.WestKPJr,LeClerqSC,ShresthaSR,etal.EffectsofvitaminAongrowthofvitamin-Adeficientchildren:fieldstudiesinNepal.JNutr1997;127:195765.WestKPJr,PokhrelRP,KatzJ,etal.EfficacyofvitaminAinreducingpre...
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Cross-SerotypeNeutralizationofDengueVirusinAotusnancymaeMonkeys
...econdaryinfectionwithAmericangenotypedengue2tocausedenguehaemorrhagicfever.Lancet1999;354:14314.Firstcitationinarticle10.InstituteforLaboratoryAnimalResearch,NationalResearchCouncil.Guideforthecareanduseoflaboratoryanimals.Washington,DC:NationalAcademyPress,1996.Firstcitationinarticle11.KochelTJ,Wat...
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RecruitingSubjectsforAcuteStrokeTrials
...ble-blind,placebo-controlledtrialofnimodipineinacutestroke.TrustStudyGroup.Lancet.1990;336:1205–1209.Clinicaltrialofnimodipineinacuteischemicstroke.TheAmericanNimodipineStudyGroup.Stroke.1992;23:3–8.LenziGL,GrigolettoF,GentM,RobertsRS,WalkerMD,EastonJD,CaroleiA,DorseyFC,RoccaWA,BrunoR.Earlytreat...
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溶栓和急诊PCI在急性心梗治疗中的作用
...ivebeneficialeffectwiththe2combinedagentswasnoted.ISIS-2CollaborativeGroup.Lancet1988;332:349–360ThrombolysisorPCIinAMIThrombolyticAgentsforAMIComprehensiveoverviewofthrombolytictherapyonAMIonearly(5-week)mortalityfromrandomizedtrialsofmorethan1000ptsbythefibrinolyticcollaborativegroup……FCGThe...
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溶栓和急诊PCI在急性心梗治疗中的作用
...ivebeneficialeffectwiththe2combinedagentswasnoted.ISIS-2CollaborativeGroup.Lancet1988;332:349–360ThrombolysisorPCIinAMIThrombolyticAgentsforAMIComprehensiveoverviewofthrombolytictherapyonAMIonearly(5-week)mortalityfromrandomizedtrialsofmorethan1000ptsbythefibrinolyticcollaborativegroup……FCGThe...
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CaseDefinitionsofClinicalMalariaunderDifferentTransmissionConditionsinKilifiDistrict,Kenya
...ogicalbasisforclinicaldiagnosisofchildhoodmalariainendemiczoneinWestAfrica.Lancet1991;338:12925.Firstcitationinarticle4.GreenwoodBM,BradleyAK,GreenwoodAM,etal.MortalityandmorbidityfrommalariaamongchildreninaruralareaofTheGambia,WestAfrica.TransRSocTropMedHyg1987;81:47886.Firstcitationinarticle5.Smit...
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StatinUseandSex-SpecificStrokeOutcomesinPatientsWithVascularDisease
...tientswithcoronaryheartdisease:theScandinavianSimvastatinSurvivalStudy(4s).Lancet.1994;344:1383–1389.WhiteHD,SimesRJ,AndersonNE,HankeyGJ,WatsonJD,HuntD,ColquhounDM,GlasziouP,MacMahonS,KirbyAC,WestMJ,TonkinAM.Pravastatintherapyandtheriskofstroke.NEnglJMed.2000;343:317–326.HeartProtectionStudyColl...
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Folatefortification:enoughalready?
...eventionofneuraltubedefects:resultsoftheMedicalResearchCouncilVitaminStudy.Lancet1991;338:1317.CzeizelAE,DudasI.Preventionofthefirstoccurrenceofneural-tubedefectsbypericonceptionalvitaminsupplementation.NEnglJMed1992;327:18325.StandingCommitteeontheScientificEvaluationofDietaryReferenceI...
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CognitiveFunctionBeforeandAfterSurgeryinPatientsWithUnrupturedIntracranialAneurysm
...:naturalhistory,clinicaloutcome,andrisksofsurgicalandendovasculartreatment.Lancet.2003;362:103–110.FukunagaA,UchidaK,HashimotoJ,KawaseT.Neuropsychologicalevaluationandcerebralbloodflowstudyof30patientswithunrupturedcerebralaneurysmsbeforeandaftersurgery.SurgNeurol.1999;51:132–139.ShinagawaF,Koba...
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Advantageofthreedimensionalanimatedteachingovertraditionalsurgicalvideosforteachingophthalmicsurgery:arandomisedstudy
...996;31:S2.GargAX,NormanG,SperotableL.Howmedicalstudentslearnspatialanatomy.Lancet2001;357:363–4.WanzelKR,HamstraSJ,AnastakisDJ,etal.Effectofvisual-spatialabilityonlearningofspatially-complexsurgicalskills.Lancet2002;359:230–1.SidhuRS,TompaD,JangR,etal.Interpretationofthree-dimensionalstructurefr...
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Importanceofn-3fattyacidsinhealthanddisease
...gJ,BangHO.HaemostaticfunctionandplateletpolyunsaturatedfattyacidsinEskimos.Lancet1979;2:4335.SiscovickDS,RaghunathanTE,KingI,etal.Dietaryintakeandcellmembranelevelsoflong-chainn-3polyunsaturatedfattyacidsandtheriskofprimarycardiacarrest.JAMA1995;274:13637.BurrML,GilbertJF,HollidayRM,etal...
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Predictiveequationsforskeletalmusclemass
...tisticalmethodsforassessingagreementbetweentwomethodsofclinicalmeasurement.Lancet1986;1:30710.GillJS,ZezulkaAV,BeeversDG,DaviesP.Relationbetweeninitialbloodpressureanditsfallwithtreatment.Lancet1985;1:5679.作者:WalterSWatson
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Maternallow-dosevitaminAorß-carotenesupplementationhasnoeffectonfetallossandearlyinfantmortality:arandomizedclustertrialinNepal
...inAsupplementationonchildhoodmortality.Arandomizedcontrolledcommunitytrial.Lancet1986;1:116973.Muhilal,PermeisihD,IdjradinataYR,Muherdiyantiningsih,KaryadiD.VitaminAfortifiedmonosodiumglutamateandhealth,growth,andsurvivalofchildren:acontrolledfieldtrial.AmJClinNutr1988;48:12716.Rah...
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VitaminD:importanceinthepreventionofcancers,type1diabetes,heartdisease,andosteoporosis
...,HolickMF.IncreasedskinpigmentreducesthecapacityofskintosynthesisvitaminD3.Lancet1982;1:74-6.WebbAR,KlineL,HolickMF.InfluenceofseasonandlatitudeonthecutaneoussynthesisofvitaminD3:exposuretowintersunlightinBostonandEdmontonwillnotpromotevitaminD3synthesisinhumanskin.JClinEndocrinolMetab1988;67:373-8....
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ResponsetoallegationsandsomeconsiderationsoninterferontreatmentinBeh?et’sdisease
...uthorship,possiblydata,andethicaltransgressions,1inourarticlepublishedintheLancet.2However,theydosowithoutknowingthecurrentfactsaboutanongoingprocess.Theyciteaccusationsthatrelyonanunfinalisedinvestigationfromtheyear2000.Aswearenowin2003,IdofeelthatIhavetopresentupdatedcorrectinformation.BeforeIdoth...
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PlasmalipidandlipoproteinresponsivenesstodietaryfatandcholesterolinpremenopausalAfricanAmericanandwhitewomen
...atindex:anindicationofthehypercholesterolemicandatherogenicpotentialoffood.Lancet1986;1:122932.LipidResearchClinicsProgram.Manualoflaboratoryoperations,lipidandlipoproteinanalyses.2nded.Washington,DC:USGovernmentPrintingOffice,1982.[DHHSpublicationno.(NIH)80-1527.]MattsonDE.Statistics:difficul...
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HowCriticalIsFibrousCapThicknesstoCarotidPlaqueStability
...to29%)carotidstenosis.EuropeanCarotidSurgeryTrialists’CollaborativeGroup.Lancet.1991;337:1235–1243.Beneficialeffectofcarotidendarterectomyinsymptomaticpatientswithhigh-gradecarotidstenosis.NorthAmericanSymptomaticCarotidEndarterectomyTrialcollaborators.NEnglJMed.1991;325:445–453.HallidayA,Mans...
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RestenosisAfterCarotidAngioplasty,Stenting,orEndarterectomyintheCarotidandVertebralArteryTransluminalAngioplastyStudy(CAVATAS)
...idandVertebralArteryTransluminalAngioplastyStudy(CAVATAS):arandomizedtrial.Lancet.2001;357:1729–1737.RITATrialParticipants.Coronaryangioplastyversuscoronaryarterybypasssurgery:theRandomizedInterventionTreatmentofAngina(RITA)Trial.Lancet.1993;341:573–580.YadavJS,RoubinGS,IyerS,VitekJ,KingP,Jordan...
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n-3Fattyacidsfromfishandfishoil:panaceaornostrum?
...gJ,BangHO.HaemostaticfunctionandplateletpolyunsaturatedfattyacidsinEskimos.Lancet1979;2:4335.DewaillyE,BlanchetC,LemieuxS,etal.n-3FattyacidsandcardiovasculardiseaseriskfactorsamongtheInuitofNunavik.AmJClinNutr2001;74:46473.ConnorWE.n-3Fattyacidsandheartdisease.In:KritchevskyD,CarrollKK,e...
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n-3Long-chainpolyunsaturatedfattyacidsreduceriskofcoronaryheartdiseasedeath:extendingtheevidencetotheelderly
...n11,324patientswithmyocardialinfarction:resultsoftheGISSI-Prevenzionetrial.Lancet1999;354:44755.LemaitreRN,KingIB,MozaffarianD,KullerLH,TracyRP,SiscovickDS.n-3Polyunsaturatedfattyacids,fatalischemicheartdisease,andnonfatalmyocardialinfarctioninolderadults:theCardiovascularHealthStudy.AmJClinNu...
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Influenceoflong-terminterventionwithdietarycounseling,long-chainn3fattyacidsupplements,orbothoncirculatingmarkersofendothelialactivat
...dhesionmolecule1andrisksoffuturemyocardialinfarctioninapparentlyhealthymen.Lancet1998;351:8892.SchumacherA,SeljeflotI,SommervollL,ChristensenB,OtterstadJE,ArnesenH.Increasedlevelsofmarkersofvascularinflammationinpatientswithcoronaryheartdisease.ScandJClinLabInvest2002;62:5968.BadimonL,Ba...
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-Linolenicacidintakeisnotbeneficiallyassociatedwith10-yriskofcoronaryarterydiseaseincidence:theZutphenElderlyStudy
....REFERENCESDyerbergJ,BangHO,AagaardO.-Linolenicacidandeicosapentaenoicacid.Lancet1980;1:199.RenaudS,NordøyA.“Smallisbeautiful“:-linolenicacidandeicosapentaenoicacidinman.Lancet1983;1:1169.KestinM,CliftonP,BellingGB,NestelPJ.n-3Fattyacidsofmarineoriginlowersystolicbloodpressureandtriglycer...
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LysinerequirementsofhealthyadultIndiansubjectsreceivinglong-termfeeding,measuredwitha24-hindicatoraminoacidoxidationandbalancetechnique
...ssionanalysisoftherelationbetweenlysineintake,leucineoxidation,andleucinebalanceThreepointscanbemadeonthebasisofthedatainTable7.First,thebreakpointoccurredconsistentlyatalysineintakeof31mg·kg-1·d-1forthe24-hoxidationanddailyleucinebalancedata.Second,thedailyrateofleucineoxidationbeyondtheb...
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CysticFibrosis,DiseaseSeverity,andaMacrophageMigrationInhibitoryFactorPolymorphism
...nsusconferencereport.Chest2004;125:1S–39S.RatjenF,DoringG.Cysticfibrosis.Lancet2003;361:681–689.KeremE,CoreyM,GoldR,LevisonH.PulmonaryfunctionandclinicalcourseinpatientswithcysticfibrosisafterpulmonarycolonizationwithPseudomonasaeruginosa.JPediatr1990;116:714–719.SteinkampG,WiedemannB.Relation...