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功能食品科学与消化道的生理及功能(一)
...酵促进了细菌的生长(生物量),同时产生短链脂肪酸(SCFA)、H2、CO2、CH4。SCFA是细菌发酵的主要终产物,是人和哺乳动物后肠(横结肠2/3位置以下的结肠)的主要阴离子,包括乙酸、丙酸、丁酸。支链脂肪酸如异丁酸/戊酸...
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腹部大手术后早期肠内营养的临床应用(附60例报告)
...F在结肠内被细菌发酵后产生短链脂肪酸(shortchainfattyacid,SCFA),SCFA为结肠黏膜上皮细胞生长必需的能量底物,这些SCFA在维持结肠的正常生长,保障结肠黏膜屏障功能的完整性等方面起着重要作用[4,5]。而对一些肠道吸收功能...
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肠功能障碍的治疗进展
...盐、丁酸盐)、氢气、二氧化碳、甲烷和水。短链脂肪酸(SCFA)易于被结肠黏膜吸收,并作为能量而利用。据估计,正常人体结肠吸收的SCFA提供每日所需能量的5%~10%,然而,在严重吸收不良者或摄高纤维饮食者,由此所获得的能量可超过...
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降结肠癌一期切除术26例临床观察
...。粪便内的食物纤维经发酵后能产生大量的短链脂肪酸(SCFA),SCFA对结肠黏膜,尤其是远端结肠黏膜的愈合有重要的生理意义[6]。其内的乙酸能增加结肠血液回流,丁酸能刺激结肠黏膜细胞的增生。Uden等通过鼠的实验研究...
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降结肠癌一期切除术26例临床观察
...。粪便内的食物纤维经发酵后能产生大量的短链脂肪酸(SCFA),SCFA对结肠黏膜,尤其是远端结肠黏膜的愈合有重要的生理意义[6]。其内的乙酸能增加结肠血液回流,丁酸能刺激结肠黏膜细胞的增生。Uden等通过鼠的实验研究...
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危重病人的免疫营养
...维才被细菌酵解,产生乙酸、丙酸和丁酸等短链脂肪酸(SCFA),而SCFA是结肠粘膜细胞的主要能量来源,可增加肠粘膜血供,促进肠粘膜细胞的增殖和分化,维护肠绒毛形态结构的完整性,同时改变肠腔内环境、抑制致病菌生长...
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肠道微生态与人体健康
...较轻的慢性肝病和肝硬化患者的临床结局。短链脂肪酸(SCFAs)是膳食纤维在结肠腔内经细菌发酵的产物,SCFA不仅是肠上皮细胞重要的能量来源,还可影响影响肠黏膜屏障,肠上皮细胞的通透性、氧化应激反应等,对结肠功能和健...
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Excretionofstarchandesterifiedshort-chainfattyacidsbyileostomysubjectsaftertheingestionofacylatedstarches
...a.E-mail:julie.clarke{at}csiro.au.ABSTRACTBackground:Short-chainfattyacids(SCFAs)havearoleinmaintainingbowelhealthandcanassistinthepreventionandtreatmentofcolonicdisease.TheabilityofacylatedstarchestodeliverSCFAstothelargebowelhasbeenshowninanimalstudiesbuthasnotbeenestablishedinhumans.Objective:The...
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Prebioticdigestionandfermentation
...ichiacoli,andClostridiumperfringenswaspoor.Usinggasandshort-chainfattyacid(SCFA)productionasendpoints,WangandGibson(12)showedthatfecalslurriesfermentedoligofructose,alongwithawiderangeofothercarbohydrates,butthatoligofructoseandinulinselectivelystimulatedgrowthofbifidobacteria.Inpurecultureexperimen...
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StudiesontheeffectsofpolydextroseintakeonphysiologicfunctionsinChinesepeople
...diminishedputrefactivemicroflora,enhancedproductionofshort-chainfattyacids(SCFAs),andsuppressedproductionofcarcinogenicmetabolites(eg,indoleandp-cresol)(3,8,10).Therefore,thesafetyandefficacyofpolydextroseasawater-solublebulkingagentandfiberhasbeenwidelyandthoroughlyinvestigated.Themetabolicroutehas...
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Small-bowelabsorptionofD-tagatoseandrelatedeffectsoncarbohydratedigestibility:anileostomystudy
...lorintheileostomybags,thepooledsampleswereanalyzedforshort-chainfattyacids(SCFAs).Inafurtherevaluationafterthemainstudy,2subjects(subjects3and5)wereaskedtoeatprepareddosesof3x5gD-tagatose/dinadditiontotheirnormaldietfor2consecutivedays.Onthethirdday,subjectswereaskedtochangebagsbeforebreakfastandthe...
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Effectsofhigh-resistant-starchbananaflour(RS2)oninvitrofermentationandthesmall-bowelexcretionofenergy,nutrients,andsterols:anileostomystu
...fstarchinresidue,pH,andconcentrationsandyieldsoftotalshort-chainfattyacids(SCFA),acetate,propionate,andbutyrateafterinvitrofermentationofilealeffluentsfor24hinstudyA1Viewlargerversion(9K):FIGURE4..StudyA.Mean(±SEM)concentrationsofbutyricacidduringinvitrofermentationofilealeffluentsobtainedfromi...
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L-Rhamnoseincreasesserumpropionateafterlong-termsupplementation,butlactulosedoesnotraiseserumacetate
...#149;L-rhamnoselactulosefecesINTRODUCTIONShort-chainfattyacids(SCFAs)areproducedbythebacterialfermentationofunabsorbedcarbohydratesinthehumancolon.The3mainSCFAsacetic,propionic,andn-butyricacidsoccurinamolarratioof60:20:20inthecoloniccontentsandfecalmatter(1).Asagroup,theSCFA...
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Consumptionoffermentedandnonfermenteddairyproducts:effectsoncholesterolconcentrationsandmetabolism
...fmicelleformationcombinedwiththeeffectoffermentationonshort-chainfattyacid(SCFA)productionweremechanismsthathadbeenproposedtoexplainthepotentialcholesterol-loweringeffectsoffermenteddairyproducts(15).Theseanimalstudiesallpointtowardacholesterol-loweringactionoffermenteddairyproducts(710,12...
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CD4memoryTcellssurviveandproliferatebutfailtodifferentiateintheabsenceofCD40
...40-deficientenvironmentforatleast18wk(Fig.S2).WhenreimmunizedwithpeptideplusCFAtheyrespondedbyproliferatingjustaswellasmemorycellsinWTmice(Fig.4).However,theywereincapableofdifferentiatingintoIFN-–producingeffectorTcells.Sothecostimulationrequirementsofmemorycellsforcelldivisionarelessstringenttha...