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阿霉素小鼠肾病模型的建立及IL18结合蛋白干预的实验研究
...鼠30只,随机分为正常对照组、阿霉素肾病造模组(ADRMCN组)、IL18结合蛋白治疗组(IL18BP治疗组)3组,用阿霉素7.5mg/kg尾静脉注射进行造模,治疗组于第5、7、12、21天腹腔注射0.5mg/kg剂量mIL18BP(鼠源性IL18结合蛋白)...
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Structure-FunctionStudiesofAllostericAgonismatM2MuscarinicAcetylcholineReceptors
...nists4-I-[3-chlorophenyl]carbamoyloxy)-2-butynyltrimethylammnoniumchloride(McN-A-343),4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]piperidinehydrogenchloride(AC-42),andthenovelAC-42derivative1-[3-(4-butyl-1-piperidinyl)propyl]-3,4-dihydro-2(1H)-quinolinone(77-LH-28-1)demonstratedanincreasedaffinity...
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对于64例胰腺囊性肿瘤的体制性研究
...瘤(IPMN),12例浆液性囊性肿瘤(SCN),11例粘液性囊性肿瘤(MCN),11例实性-假乳头状肿瘤(SPN)以及2例囊性变性的实体瘤,通过免疫组织化学检测MUC1,MUC2,MUC4,MUC5AC,MUC6以及其他相关抗原的表达。结果可见,IPMN和交界区域的腺瘤类型MUC2和...
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2003~2006年海盐县部分人群HIV监测情况分析
...业人员血样标本开展HIV抗体检测。结果4年间共检测血样4853份,检出HIV抗体阳性7例(6人),其中2003年检出HIV抗体阳性例数0,2004年阳性例数1,2005年阳性例数为1(该例与2004年阳性例为同一人),2006年阳性例数为5。其中自愿检...
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PNAS:诊断胰腺囊肿的新方法
...乳头状瘤(IPMN)、浆液性囊腺瘤(SCA),粘液性囊肿(MCN)和假乳头状实体瘤(SPN)进行了研究。结果发现每一类型的囊肿都有其特异性的基因改变:SCA的3号染色体片段丢失,破坏了抑癌基因VHL的活性;MCN的生长驱动癌基因KRAS...
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ANovelClassofPositiveAllostericModulatorsofMetabotropicGlutamateReceptorSubtype1InteractwithaSiteDistinctfromThatofNegativeAllostericMo
...lacetylcarbamate(Ro01-6128),andbutyl(9H-xanthene-9-carbonyl)carbamate(Ro67-4853)]displacedthebindingof[3H]1-(3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-2-phenyl-1-ethanone(R214127),ahigh-affinityradioligandfortheallostericantagonistsiteonmGluR1atconcentrationsseveralordersofmagnitudehigherthanthoser...
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HIV和妊娠:护理实践上的考虑
2006年08月17日MCN-THEAMERICANJOURNALOFMATERNAL-CHILDNURSING31(4):233-240JUL-AUG200615在美国,患上HIV的育龄妇女的数目在不断的增多。妇女也常常在怀孕后检查中才得知自己患上了HIV。自从1981年这种疾病被确认以来,在对其的治疗手段上已经有...
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TheOphthalmologyExaminationsReview
UniversityofCalifornia,SanFrancisco,CA,USA;dfrase@mcn.orgByTienYinWong.Pp448;$84.Singapore:WorldScientificPublishing,2001.ISBN9810243995Preparingforpostgraduateexaminationsisnowanearlyuniversaleventforophthalmologistsintraining.Inmanycountriesitwillbecomeapartofapractisingophthalmologist’sprofessi...
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MiniNutritionalAssessment(MNA):ResearchandPracticeintheElderly
...nVanderbiltCenterforHumanNutrition,VanderbiltUniversityMedicalCenter,C2104,MCN,Nashville,TN37215E-mail:gordon.jensen{at}mcmail.vanderbilt.eduNestleNutritionWorkshopSeriesClinicalPerformanceProgramme,volume1,editedbyBrunoVellas,PhilipJGarvey,andYvesGuigoz,1999,195pages,hardcover,$137.50.SKargerAG,Bas...
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加味生化颗粒
...加味生化颗粒生产企业:武汉市中联制药厂批准文号:ZZ-4853-鄂卫药准字(1984)第000341号规格:15g/袋剂型:颗粒剂省份:湖北申请编号:98299公告号:22公告日期:1999-9-28保护级别:2级保护起始日:1999-9-28保护终止日:2006-9-28保护...
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上颌尖牙埋伏阻生的临床分析
2007年05月08日中华口腔医学杂志2006Vol.41No.8P.483-4853(北京)为了对上颌尖牙埋伏阻生的患病特点及治疗结果进行分析,以期为临床治疗上颌尖牙埋伏阻生提供参考数据。研究者在北京大学口腔医学院•口腔医院正畸科门诊2001...
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Lowerserumalbuminconcentrationandchangeinmusclemass:theHealth,AgingandBodyCompositionStudy
...reventionSciencesGroup,UniversityofCalifornia,SanFrancisco,SanFrancisco,CA(MCN);theNationalInstituteonAging,LaboratoryofEpidemiology,DemographyandBiometry,Bethesda,MD(TBH)2SupportedbyNationalInstituteonAgingcontractsNO1-AG-6-2101,NO1-AG-6-2103,andNO1-AG-6-2106.TheresearchofMVwasmadepossiblebyafellow...
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附表3t值表
...7172.0742.5082.8193.1193.5053.79223 0.6851.3191.7142.0692.5002.8073.1043.4853.76824 0.6851.3181.7112.0642.4922.7973.0913.4673.74525 0.6841.3161.7082.0602.4852.7873.0783.4503.72526 0.6841.3151.7062.0562.4792.7793.0673.4353.70727 0.6841.3141.7032.0522.4732.7713.0573.4213.69028 0.6831.3131....
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应用于帕金森症药物治疗的新型纳米技术
...。Ngwuluka等人使用的甲基丙烯酸酯共聚物-脂质纳米颗粒(MCN)系统来递送口服左旋多巴。这种纳米粒子是采用多交联技术制成的,并且具有多个属性,研究人员发现他们的纳米粒子可以持续的释放左旋多巴,并认为这种运载系统...
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DDR成像技术在胸部检查中的价值
...变:785例显示率为9.09%。在阳性病例中直接定性的病例:4853例显示定性率为83.89%。 3讨论 DDR图像的采集和处理在计算机控制下实行完全自动化,避免了影像成像链上诸多环节的干扰,减少了图像的噪音和失真,提高了影...
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吉首地区病原菌的耐药调查
...0种包括:青霉素G(PCG),苯唑西林钠(OCS),美洛西林(MCN),氨苄西林(AMP),头孢唑啉(CFZ),红霉素(EM),四环素(TAC),氯林霉素(CDM),磺胺甲基异唑(SMZ),利福平(RFP),亚胺培南一西司他丁(IPC),万古霉...
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Lackofarelationbetweenvitaminandmineralantioxidantsandbonemineraldensity:resultsfromtheWomen‘sHealthInitiative
...ologyandBiostatistics,UniversityofCaliforniaatSanFrancisco,SanFrancisco,CA(MCN,JAS,andKLS);theGeneralInternalMedicineSection,SanFranciscoVAMedicalCenter,SanFrancisco,CA(JAS);andtheUniversityofBuffalo,Buffalo,NY(JWW)2Supportedbytraininggrantno.5T32AG000181-15fromtheNationalInstitutesofHealth.3Reprint...
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InteractionStudiesofMultipleBindingSitesonM4MuscarinicAcetylcholineReceptors
...ts[acetylcholine,4-(m-chlorophenylcarbamoyloxy)-2-butynyltrimethylammonium(McN-A-343),orxanomeline]revealedlowdegreesofnegativecooperativitybetweenWIN62,577andeachagonist,whereasstrongernegativecooperativitywasobservedagainstatropine.Itisinterestingthatwhentheseexperimentswererepeatedusingtheprototy...
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TheEpidemiologyofIntestinalMicrosporidiosisinPatientswithHIV/AIDSinLima,Peru
...ronicdiarrhoeaamongHIV-infectedadultpatientsinNairobi,Kenya.JInfect1998;37:4853.Firstcitationinarticle3.BeaugerieL,CarbonnelF,CarratF,etal.FactorsofweightlossinpatientswithHIVandchronicdiarrhea.JAcquirImmuneDeficSyndrHumRetrovirol1998;19:349.Firstcitationinarticle4.LubeckDP,BennettCL,MazonsonPD,Fife...
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Effectivenessofseleniumsupplementsinalow-seleniumareaofChina
...p(Piscataway,NJ).3Reprintsnotavailable.AddresscorrespondencetoRFBurk,C2104,MCN,VanderbiltMedicalCenter,Nashville,TN37232-2279.E-mail:raymond.burk{at}vanderbilt.edu.ABSTRACTBackground:Seleniumisanessentialmicronutrientwitharecommendeddietaryallowanceforadultsof55µg/d.Itfunctionsasanessentialcons...
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MastocytosisinmiceexpressinghumanKitreceptorwiththeactivatingAsp816Valmutation
...nhibitorPP1alsoinhibitsKitandBcr-Abltyrosinekinases.J.Biol.Chem.278:4847–4853.Longley,B.J.,D.D.Metcalfe,M.Tharp,X.Wang,L.Tyrrell,S.Z.Lu,D.Heitjan,andY.Ma.1999.Activatinganddominantinactivatingc-kitcatalyticdomainmutationsindistinctclinicalformsofhumanmastocytosis.Proc.Natl.Acad.Sci.USA.96:1609–1...
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ActinandagonistMHC–peptidecomplex–dependentTcellreceptormicroclustersasscaffoldsforsignaling
...nhibitorPP1alsoinhibitsKitandBcr-Abltyrosinekinases.J.Biol.Chem.278:4847–4853.Rozdzial,M.M.,B.Malissen,andT.H.Finkel.1995.Tyrosine-phosphorylatedTcellreceptorzetachainassociateswiththeactincytoskeletonuponactivationofmatureTlymphocytes.Immunity.3:623–633.Dustin,M.L.,andJ.A.Cooper.2000.Theimmunol...
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Recombinanthumangrowthhormoneimprovesmuscleaminoaciduptakeandwhole-bodyproteinmetabolisminchronichemodialysispatients
...versityMedicalCenter,116121stAvenueSouthGarland,DivisionofNephrology,S-3223MCN,Nashville,TN37232-2372.E-mail:alp.ikizler{at}vanderbilt.edu.ABSTRACTBackground:Intradialyticparenteralnutrition(IDPN),withorwithoutexercise,hasbeenshowntoreversethenetnegativewhole-bodyandforearmmuscleproteinbalancesobser...
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HIV-1ChemokineCoreceptorUtilizationinPairedCerebrospinalFluidandPlasmaSamples:ASurveyofSubjectswithViremia
...notedinmore-extensiveanalysisofenvsequences[46,47]orpolresistancemutations[4853]todefinevirusgenotypesinthe2compartments.Weobserveddiscordanceinbothdirections,including2examplesoftheR5phenotypeinplasmaandtheR5+X4phenotypeinCSF.Thislatterfindingisstriking,giventheoverallfrequencyoftheR5phenotypeinCSF...
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Zincprotectsrenalfunctionduringcadmiumintoxicationintherat
...ion,andchromosomalmappingofthehumanepithelialCa2+channel(ECAC1).Genomics67:4853,2000.NishiyamaSandNakamuraK.Effectofcadmiumonplasmaaldosteroneandserumcorticosteroneconcentrationsinmalerats.ToxicolApplPharmacol76:420425,1984.NogawaK,KobayashiE,YamadaY,HondaR,KidoT,TsuritaniI,andIshizakiM.Parathyroidh...
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UseoftheDuplexTaqManPCRSystemforDetectionofShiga-LikeToxin-ProducingEscherichiacoliO157
...fEscherichiacoliO157:H7indairywastewaterwetlands.Appl.Environ.Microbiol.68:4853-4862.Jaykus,L.A.2003.Challengestodevelopingreal-timemethodstodetectpathogensinfoods.ASMNews69:341-347.Jones,D.L.1999.PotentialhealthrisksassociatedwiththepersistenceofEscherichiacoliO157:H7inagriculturalenvironment.SoilU...
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TherapeuticAngiogenesisUsingNovelVascularEndothelialGrowthFactor-E/HumanPlacentalGrowthFactorChimeraGenes
...ssesjointdestructionintheK/BxNmodelofrheumatoidarthritis.JImmunol.2003;171:4853-4859.ThurstonG,SuriC,SmithK,McClainJ,SatoTN,YancopoulosGD,McDonaldDM.Leakage-resistantbloodvesselsinmicetransgenicallyoverexpressingangiopoietin-1.Science.1999;286:2511-2514.DetmarM,BrownLF,SchonMP,ElickerBM,VelascoP,Ric...
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Predictorsofpostprandialtriacylglycerolresponseinchildren:theColumbiaUniversityBiomarkersStudy
...7kJ(632kcal)/m2.Theformulawaspreparedwithadairydigestivesupplement(Lactaid;McN-PPC,Inc,FortWashington,PA)24hbeforeadministration.Aqueousretinylpalmitate(50000IU,or1g/m2bodysurfacearea)wasadded(Vitadrel-Tropfen;Pharma-Wernigerode,Wernigerode,Germany)onthedayofthestudy.Onthemorningofthedayofthetest,th...
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SuppressionofthePhosphorylationofReceptorTyrosinePhosphatase-ontheSrc-IndependentSiteTyrosine789byReactiveOxygenSpecies
...naseinhibitorPP1alsoinhibitsKitandBcr-Abltyrosinekinases.JBiolChem278:4847-4853.[Abstract/FreeFullText]TsaiW,MorielliAD,CacheroTG,andPeraltaEG(1999)Receptorproteintyrosinephosphatasealphaparticipatesinthem1muscarinicacetylcholinereceptor-dependentregulationofKv1.2channelactivity.EMBO(EurMolBiolOrgan...
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Physiologicaloxygenationstatusisrequiredforfullydifferentiatedphenotypeinkidneycortexproximaltubules
...8mitogen-activatedproteinkinaseisrequiredforhypoxiasignaling.MolCellBiol25:4853-4862,2005.FineLG,OrphanidesC,andNormanJT.Progressiverenaldisease:thechronichypoxiahypothesis.KidneyInt65:S74-S78,1998.GarciaCK,BrownMS,PathakRK,andGoldstein.JL.cDNAcloningofMCT2,asecondmonocarboxylatetransporterexpressed...