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单体素氢质子磁共振波谱研究口腔颌面部恶性肿瘤
...学空间(MEDcyber.com)5月18日消息,单体素氢质子磁共振(1HMR)波谱能为口腔颌面部软组织恶性肿瘤的诊断提供有益信息。口腔颌面部的恶性肿瘤以癌为常见,肉瘤较少。癌肿中绝大多数为鳞状细胞癌,其次为腺性上皮癌,还有基底...
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Conditionalgeneexpressioninrenalcollectingductepithelialcells:useoftheinducibleCre-loxsystem
...enhancedgreenfluorescentprotein(eGFP)-taggedhumanmineralocorticoidreceptor(hMR)inthealdosterone-responsiveRCCD2cellline(8).MATERIALSANDMETHODSCellCultureRCCD2cellswereculturedonpetridishesthathadbeencoatedwithrattypeIcollagen,aspreviouslydescribed(8).Cellswereculturedinadefinedmediumthatcontained1:1...
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TargetedSkinOverexpressionoftheMineralocorticoidReceptorinMiceCausesEpidermalAtrophyPrematureSkinBarrierFormationEyeAbnormalitiesandAlopeci
...MRspecificallytokeratinocytesoftheepidermisandhairfollicle(HF).ExpressionofhMRthroughoutgestationresultedinearlypostnataldeaththatcouldbepreventedbyantagonizingMRsignaling.DTmiceexhibitedprematureepidermalbarrierformationatembryonicday16.5,reducedHFdensityandepidermalatrophy,increasedkeratinocyteapo...
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SolubleGuanylylCyclaseActivationWithHMR1766AttenuatesPlateletActivationinDiabeticRats
...tarrats.After2weeks,treatmentwitheitherplaceboortheguanylylcyclaseactivatorHMR1766(10mg/kgtwicedailybygavage)wasinitiated.Twoweekslater,invivoplateletactivationandinvitroplateletreactivitywereassessed.ChronictreatmentwithHMR1766enhancedNO/cGMP-mediatedsignalinginplateletsfromdiabeticratsdeterminedby...
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国产格列美脲治疗2型糖尿病的疗效观察
...纪80年代由德国HoechstAG药厂开发成功,1995年被美国FDA批准HMR公司的Amaryl作为2型糖尿病临床用药在美国上市。Amaryl作为进口药物,价格昂贵,国人难以支付。目前国内已出现了国产的格列美脲,并已在临床上应用,但其临床研究...
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Benefitsandrisksofantiobesityagents
...olicResearchGroup,VeteransAdministrationMedicalCenter,UniversityofKentucky(HMR)WeightManagementProgram,UniversityofKentuckyLexington,KYDearSir:Aftersuccessfulweightloss,long-termweightmaintenanceisdifficultandoftennotsuccessful(1).Whereasrecentstudies(1,2)indicatethatlong-termweightmaintenanceafterv...
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ProteinKinaseGTransmitstheCardioprotectiveSignalFromCytosoltoMitochondria
...chemicalswerefromSigmaChemicalCo.KT5823,TPP+,andcpt-cGMPwerefromCalbiochem.HMR1098wasagiftofDrHeinrichEnglertofSanofisAventis(Frankfurt,Germany).CyclicGMPproteinkinase1(PKG)waspurifiedfrombovinelung.15PKCisozyme-specificpeptideantagonistsV1-2(EAVSLKPT)16andV1-1(SFNSYELGSL)17weresynthesizedwithapurit...
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缓慢激活延迟整流钾通道(IKs)的研究进展*
...IKs对甲磺酸盐类有抵抗作用,但可被色原烷醇类(293B、HMR-1556),吲哚帕胺,硫喷妥钠,异丙酚和地西泮(L-768、673,L735、821或L-7)选择性阻断[15~17]。此外,色原烷醇类对于开放通道的阻断作用具有对映选择性,(-)3R,4S-2...
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Effectofacutedietarystandardizationontheurinary,plasma,andsalivarymetabolomicprofilesofhealthyhumans
...t,DivisionofClinicalandMolecularMedicine,TrinityCollege,Dublin,Ireland(MCW,HMR,andMJG),andtheUCDSchoolofBiomolecularandBiomedicalSciences,UCDConwayInstituteofBiomolecularandBiomedicalResearch,UniversityCollegeDublin,Belfield,Dublin,Ireland(LBandJPGM)2SupportedbytheIrishResearchCouncilforScience,Engi...
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不明原因骨痛病人骨显像检查结果分析
...droutinenuclidewholebodyboneimaging.AnanalysiswasdonebycombinationwithMR,CT,andXray.ResultsOfthe247patients,201werepositiveinimaging(81.4%).Thecommoncausesofbonepainaremetastasisofthemalignancy,intervertebraldiscprotrusion,hyperosteosis,andosteoporosis.ConclusionBoneimagingisofgreatervaluei...
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CellularMechanismofCalcium-MediatedTriggeredActivityintheHeart
...hepreparationtoaCCDvideocamera.ExperimentalProtocolIn12wedgesfrom12animals,HMR1556(7eol/L),aselectiveIKschannelblocker,24andIsoproterenol(0.2eol/L),a-adrenergicstimulant,wereadministeredsimultaneouslytoenhancecalciumentry.Thismodelhasbeenshownpreviouslytobeassociatedwithtriggeredactivityinsinglecell...
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促红细胞生成素对缺血再灌注心脏的心肌保护作用
...4MAP激酶)、白屈菜赤碱(PKC)以及K+通道阻滞剂优降糖、HMR1098,5-HD和Paxilline所阻断;在应用EPO之前(2.3±0.9nmol/min/g)和15min之后(2.4±1.9nmol/min/g)心脏所释放的硝酸盐及亚硝酸盐没有差别;而L-NAME和L-NMA则对EPO的保护作用没有影...
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针对新靶点开发抗肿瘤药物
...试验中显示出良好的抗肿瘤活性。 Flavopiridol(L86-8275,HMR1275)是CDK2和CDK4的双重抑制剂,阻止细胞的G2/M过渡以及细胞从G1期进入S期。Ⅰ、Ⅱ期临床数据显示,Flavopiridol对RCC的反应率良好,肿瘤体积的减小程度高于50%。 UCN-01...
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SmallorganswithahighmetabolicrateexplainlowerrestingenergyexpenditureinAfricanAmericanthaninwhiteadults
...andbrain)andthereforealowerproportionofbodymassashigh-metabolic-rate(HMR)tissuesthandowhites.Ifthishypothesisprovestobetrue,thenthepreviouslyreportedlowerREEinAfricanAmericansmaybeexplainedtotallyorinpartbydifferencesinthecompositionofthebodysFFMcompartment.SUBJECTSANDMETHODSSubjec...
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雌激素对脑缺血的神经保护作用机制
...004,5(6):411-419. 10VogelvangTE,MijatovicV,KenemansP,etal.HMR3339,anovelselectiveestrogenreceptormodulator,reducestotalcholesterol,low-densitylipoproteincholesterol,andhomocysteineinhealthypost-menopausalwomen.FertilSteril,2004,82(6):1540-1549. 11TomirnotoH,Ak...
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Onehundred–poundweightlosseswithanintensivebehavioralprogram:changesinriskfactorsin118patientswithlong-termfollow-up
...niversityofKentucky(UK)isapartnershipbetweenUKandHealthManagementResources(HMR;Boston,MA).Since1985,attheUK-HMRProgram,weightlossesof100pounds(45.5kg)havebeenacknowledged,weeklyweightshavebeenrecorded,andfollow-upweightshavebeenrecordedbyoneofus(JWA).Since1995,datafromalltreatedpatientshavebeenmaint...
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Renalepithelialcellsconstitutivelyproduceaproteinthatblocksadhesionofcrystalstotheirsurface
...iminatemoleculeswithanapparentMrof<30,000.ThefractioncontainingmoleculeswithMr30,000wasloadedontoaDEAE-Sepharoseanion-exchangecolumnandwaselutedwith0.4MNaCl.TheeluatewasthenappliedtoaBiogelA0.5Msizingcolumn.ActivitywasdetectedinfractionsconsistentwithanapparentMrbetween60,000and100,000,withpeakactiv...
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RenalcorticalregulationofCOX-1andfunctionallyrelatedproductsinearlyrenovascularhypertension(rat)
...on.AmJPhysiolRenalFluidElectrolytePhysiol253:F377-F387,1987.BosseHM,BöhmR,ReschS,andBachmannS.ParallelregulationofconstitutiveNOsynthaseandreninatthejuxtaglomerularapparatusofratkidneyundervariousstimuli.AmJPhysiolRenalFluidElectrolytePhysiol269:F793-F805,1995.BreyerMDandBreyerRM.Gprotein-coupl...
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ChlamydophilapneumoniaeandMycoplasmapneumoniae
...DiayeEN,Collart-DutilleulV,Maridonneau-PariniI,Diu-HercendA.ThenewketolideHMR3647accumulatesintheazurophilgranulesofhumanpolymorphonuclearneutrophils.AntimicrobAgentsChemother1999;43:2457–2462.PhamGiaH,RoederV,NamourF,SultanE,LenfantB.HMR3647achieveshighandsustainedconcentrationsinwhitebloodcellsi...
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OntheMechanismofActionof9-O-ArylalkyloximeDerivativesof6-O-Mycaminosyltylonolide,aNewClassof16-MemberedMacrolideAntibiotics
...文献】AckermannGandRodloffAC(2003)Drugsofthe21stcentury:telithromycin(HMR3647)-thefirstketolide.JAntimicrobChemother51:497-511.[Abstract/FreeFullText]BerisioR,HarmsJ,SchluenzenF,ZarivachR,HansenHAS,FuciniP,andYonathA(2003)Structuralinsightintotheantibioticactionoftelithromycinagainstresistantmuta...
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Antagonisticeffectsofbonemorphogeneticprotein-4and-7onrenalmesangialcellproliferationinducedbyaldosteronethroughMAPKactivation
...betweentheindicatedgroups.SincethesealdosteroneeffectsappearedtooccurthroughMR,weexaminedchangesofMRexpressionlevelsinMES13cells.Quantitativereal-timePCRanalysisshowedthatANGII(30nM)reducedAT1RmRNAlevelswhilealdosterone(100nM)reducedMRexpressioninthiscellline(Fig.9A),suggestingthepresenceofafunction...