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毕赤酵母菌表达弓形虫GRA1蛋白接种小鼠免疫效果
【摘要】目的观察毕赤酵母菌表达弓形虫GRA1蛋白免疫效果。方法采用皮下注射法免疫接种小鼠,末次免疫后第2周用ELISA检测其特异性抗体水平;流式检测鼠脾淋巴细胞亚群,末次免疫后第3周,用弓形虫RH株速殖子分别攻击感染...
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弓形虫GRA6可溶性蛋白在大肠埃希菌中的表达及纯化
...8-1518(苏州)为了在大肠埃希菌中高效表达及纯化弓形虫GRA6抗原,为制作弓形虫感染基因工程诊断试剂盒奠定基础。研究者将重组pGEX-GRA6表达载体转化大肠埃希菌BL21-CodonPlus(DE3)-RP菌株,在异丙基硫代-β-D半乳糖苷(IPTG)诱导下表...
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我国弓形虫病核酸疫苗研究概况
...形虫裂殖了表面膜蛋白(SAG)[1,2],致密颗粒蛋白(GRA)[3]和棒状体蛋白(ROP)[4]是重要的弓形虫抗原,这些抗原物质与弓形虫的侵袭性有关,且能诱导宿主的免疫反应。 1.1SAGSAG是弓形虫裂殖子表面膜蛋白。通过...
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灭滴灵致白细胞减少2例
...。化验血RBC5.43×1012/L,Hb147g/L,WBC13.3×109/L,GRA85%,LYM12%。诊断为:急性阑尾炎。患者拒绝手术要求保守治疗,给予先锋霉素V2g及灭滴灵0.5g静滴,每日2次,共用6天。用药第2天体温降至正常,腹痛明显缓解。第3天复...
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严重急性呼吸综合征的实验室检查概述
...外周血白细胞计数(WBC)正常或降低,中性粒细胞分类(GRA%)和中性粒细胞计数(GRA)增高;淋巴细胞计数(LYM)及淋细胞分类(LYM%)偏低;血沉(ESR)升高。广东省260例SARS患者血常规结果显示,WBC大于10×109/L者占15%,正常(4~...
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刚地弓形虫分子疫苗研究新进展
...,主要有表面抗原(Surfaceantigen,SAG)、致密颗粒蛋白(Densegranulesprotein,GRA)、棒状体蛋白(Rhoptryprotein,ROP)和微线体蛋白(Micronemeprotein,MIC)等。 1.1P30、P22、P18和P35表面抗原(SAG) P30蛋白又称表面抗原1(SAG1),为速殖子期特异性...
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激素抵抗型哮喘1例
...较严重,更易出现夜间喘息症状,晨间肺功能差等特点。GRA患者首先应哮喘诊断明确,并应排除其他可致喘息或加重的疾病及药物相关性哮喘,如临床上常用的β受体阻滞剂、非甾体抗炎药物和血管紧张素转换酶抑制剂所致的...
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传染性单核细胞增多症误诊为化脓性扁桃体炎2例分析
...,烦躁、腹部不适,家长要求查血常规,示:WBC17.6×109/L,GRA11.6%,LYM76.4%,MON12%。转入我院门诊就诊。当日复查血常规,示WBC17.9×109/L,GRA9%,LYM80.1%,MON10.9%。外周血涂片示:异型淋巴细胞27%,未见幼稚细胞。查体:T37.8℃,神志清...
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应用血细胞分析仪与血涂片的比较
...LYM)为0.58,中间细胞百分比(MID)为0.12,中性粒细胞百分比(GRA)为0.30。后涂片检查,可见幼稚白细胞为2%,经骨髓穿刺检查诊断为骨髓异常综合征(MDS)。病例2:男,38岁。因头晕、面黄就诊。用迈瑞BC-3000三分类细胞分析仪测定:...
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单基因遗传性高血压
...素可治疗性醛固酮增多症(glucocorticoidremediablealdosteronism,GRA)、Liddle综合征、拟似盐皮质激素过多症(apparentmineralocorticoidexcess,AME)和Bilginturan综合征,相信将来还会有新的单基因性高血压被确认。 1.1糖皮质激素可治疗性醛...
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Whole-grainconsumptionisassociatedwithareducedriskofnoncardiovascular,noncancerdeathattributedtoinflammatorydiseasesintheIowaWomen‘sHealth
...onotnecessarilyrepresenttheofficialviewofthefundingbodies.3RBwassupportedbygrantsfromtheNorwegianResearchCouncil,TheJohanThroneHolstNutritionResearchFoundation,andTheNorwegianCancerSociety.DRJwassupportedbytheNorwegianResearchCouncilandbyagrant(RO1CA39742)fromtheNationalCancerInstitute.4Addressrepri...
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十二指肠溃疡穿孔外科治疗体会
...壁覆盖溃疡者称为Nissen法,采用残端后壁覆盖溃疡者称为Gra-ham法。本组32例B-Ⅱ式术中采用Bancroft法6例,Gra-ham法2例,开放远端作十二指肠内引导分离3例,利用肠浆肌层覆盖加强端的闭合。32例B-Ⅱ式吻合口胃管均置入输入肠段,...
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自发性子宫穿孔2例报告
...触及。肠鸣音稍弱。血常规示:WBC32.2×109/L,LYM7.3%,GRA87.9%;腹部平片示:膈下游离气体,考虑空腔脏器穿孔;GLU25.24mmol/L,患者病情危重,血糖明显高于正常值,及时请内科会诊,给予胰岛素对抗血糖水平,同时告知家属术中...
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急性重度地瓜米中毒1例
...2/L,Hb117g/L,PLT337×109/L,WBC49.3×109/L↑,LYM24.8%,MID15.7%,GRA59.5%↑。血气分析pH7.088↓,PaCO21.77kPa↓,PaO212.20kPa↓,TcSO295%(吸氧状态下)。提示:失代偿性代谢酸中毒。血电解质示钠133.0mmol/L↓,钾4.70mmol/L,氯96mmol/L,钙2.17mmol/L...
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毒蕈中毒致死亡1例
...;mol/L,总蛋白70.7g/L,白蛋白44.2g/L,血常规:WBC11.5×109/L,GRA78.7%,Cr87μmol/L,尿素氮5.2μmol/L。肌酸激酶38.3u/L。肌酸激酶同工酶31u/L,乳酸脱氢酶1154.3u/L,α-羟丁酸脱氢酶346.3u/L。凝血分析PT64.2s,PT的INR比值5.35。PT的活动度10...
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Intakesofwholegrains,bran,andgermandtheriskofcoronaryheartdiseaseinmen
...ol,Boston(FBHandEBR)Seecorrespondingeditorialonpage14592SupportedbyresearchgrantsHL35464andCA55075fromtheNationalInstitutesofHealthandascholarshipfromtheDanishResearchFoundation(toMKJ).TheKelloggCompanyprovidedunrestrictedfundingofthedevelopmentofthewhole-graindatabase.3Reprintsnotavailable.Addressc...
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ACombinationofAntigenicRegionsofToxoplasmagondiiMicronemeProteinsInducesProtectiveImmunityagainstOralInfectionwithParasiteCysts
...oleculesthatbelongto3majorproteinfamilies:thesurfaceantigens(SAGs),thedensegranuleexcreted-secretedantigens(GRAs),andtherhoptryantigens(ROPs).Themicronemeproteinslookparticularlypromisingbecausetheyareresponsiblefortheadhesionandinvasionprocessofallapicomplexanparasites[18,19].Werecentlydemonstrated...
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Whole-grainintakecoolsdowninflammation
...fcardiovasculardisease(CVD)mortalityinolderpeopleconsumingdietshighinwhole-grainfoods.Althoughtheseresultsareforthemostpartconfirmatory,addingtotheexistingevidencethatwhole-grainintakemayconferprotectionagainstthemetabolicsyndromeandCVDrisk,themessageaboutthehealthybenefitsconferredbyincreasingwhole...
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造血干细胞移植后急性移植物抗宿主病发生与颗粒酶B、穿孔素及FasL基因表达的相关性
...干细胞移植后体内Fas配体(FasL)、穿孔素(Perforin)及颗粒酶B(GranzymeB)基因转录水平的动态变化与急性移植物抗宿主病(aGVHD)发生及发展的关系。研究者应用竞争性定量RT-PCR方法检测17例白血病患者造血干细胞移植后GranzymeB、Perforin及Fas...
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染发致骨髓增生异常综合征1例
...凹陷性水肿。实验室检查:血常规:WBC2.1×109/L,LYM60.7%,GRA35.5%;RBC1.28×1012/L,HGB55g/L,HCT0.177,MCV99FCH,MCH31.2pg;PLT64×109/L。大便常规:正常,OB(-)。尿十项+镜检:正常。ESR85mm/h,CRP5mg/L,肾功能、肝功能正常,电解质正常,T68...
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酒精中毒后继发周围性神经炎案
...C5.6×109/L,RBC3.86×1012/L,HGB102g/L,PLT120×109/L,GRA69%,CO2-CP36mmol/L。本病属中医“痿证范畴,证属湿毒阻络,治法拟以除湿解毒、通经活络之法,以电针治疗为主,取穴:百会、四神聪、两侧肩髃、臂臑、下极泉、曲...
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宫内双胎并宫外妊娠1例
...。血常规:RBC2.69×1012/L,PLT176×109/L,WBC29.7×109/L,LYM10%,GRA87%,AGB84g/L,MCH31pg,MCHC357g/L。临床诊断:宫内双胎妊娠并宫外孕破裂,失血性休克。于2004年6月18日行剖腹探查术,术中发现腹腔内大量血液并血块,共约2500ml,左输卵管...
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Whole-andrefined-grainintakesandtheriskofhypertensioninwomen
...orniaatLosAngelesSchoolofPublicHealth,LosAngeles,CA(SL)2SupportedbyresearchgrantsCA-047988andHL-080467fromtheNationalInstitutesofHealth.3Reprintsnotavailable.AddresscorrespondencetoLWang,BrighamandWomen‘sHospital,900CommonwealthAvenueEast,BostonMA02215.E-mail:luwang{at}rics.bwh.harvard.edu.ABSTRAC...
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隐源性肝脓肿1例报告
...块,无移动叩浊,听肠鸣4次/min。血常规:WBC20.3×109/L,GRA90.4%,LYM4.8%。尿常规:GLU++。血糖19.16mmol/L。胸透:左肺下野纹理增多、紊乱,左肋膈角变钝。彩超见图1,CT见图2。诊断为细菌性肝脓肿,立即给予急诊经左腹直肌切口手...
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妊娠肝内胆汁淤积症误诊为妊娠合并急性黄疸型肝炎1例
...产科门诊检查,血常规:HGB110g/L,WBC9.07×109/L,LYM137%,GRA84.7%,MON1.8%,BT30s,CT6min30s,BG(A)型。小便常规:BIL(+++),PRO(+),NIT微量,余正常。B超:(1)肝胆未见明显异常;(2)宫内死胎。门诊即以死胎引产收住院。查体:皮肤轻...
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血透致右前臂肌间动脉渗出血1例超声图像报告
...肺腹(-),双踝部轻度凹陷性水肿。血常规:WBC3.5×109/L,GRA79.1%,HB26g/L,PLT55×109/L。生化:肝功正常。尿素氮44.9mmol/L,肌酐1021μmol/L,尿酸1024μmol/L。钾639mmol/L,钙1.45mmol/L,磷2.79mmol/L。尿常规:GLU(-),PRO(-),WBC(-),BLD(+++...
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急性传染性淋巴细胞增多症漏诊1例原因分析
...色斑丘疹。实验室检查:门诊血液分析WBC35.5×109/L,GRA15.5×109/L。胸部X线片:两肺纹理增多紊乱、模糊,右下肺透光度减低,可见片状淡薄影,密度不均,边界模糊。入院后查肺炎支原体抗体阴性,大便轮状病毒抗原阴性...
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Effectofwholegrainsoninsulinsensitivityinoverweighthyperinsulinemicadults,
...andtheInstituteofNutritionResearch,UniversityofOslo(DRJ).2SupportedinpartbygrantMO1-RR00400fromtheNationalCenterforResearchResources;grantT32HL07779fromtheNationalHeart,Lung,andBloodInstitute;aresearchawardfromtheDivisionofEpidemiology,UniversityofMinnesota;andagiftfromGeneralMills,Inc,GoldenValley,...
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Nutrients,foods,anddietarypatternsasexposuresinresearch:aframeworkforfoodsynergy
...patternsactsynergisticallytoinfluencetheriskofseveralchronicdiseases.Whole-grainconsumptionandriskofdiseasearepresentedasamodeloffoodsynergy.Foodsynergyisdefinedasadditiveormorethanadditiveinfluencesoffoodsandfoodconstituentsonhealth.Riskappearstobelowerwithconsumptionofwholegrainthanofrefinedgrain;...
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ReplytoKariluotoetal
...ouslypublishedresults(3),nootherparticipatinglaboratoryusedaffinitychromatographyasacleanupstepbeforethefinaldeterminationofallvitamerswithHPLC.Selhub(4)andPfeifferetal(5)usedthistechniquesuccessfullyearlier.Itmustbestressedthatonlythiscleanupprocedureissuitablefordeterminingthefolatecontentinfood-s...