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干燥综合征神经系统损伤的临床病理分析
...经科杂志2005Vol.38No.7P.434-4379(济南)为了探讨原发性干燥综合征(Sj(o)gren综合征)神经系统损伤的临床病理特征及其机制。研究者取8例患者均符合欧洲原发性Sj(o)gren综合征的诊断标准,其中唇黏膜活检5例,腓肠神经活检5例,肱二...
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芳香酶抑制剂与关节疼痛
...的动物实验研究显示,芳香酶敲除大鼠会出现Sjögren样综合征的表现。作者:
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CentralnervoussystemmechanismsinSjögren’ssyndrome
...,3508TAUtrecht,TheNetherlands Atheory Keywords:fibretransmission;Sjogren’ssyndrome;parasympatheticinhibition;dryeyesTheoriginofthedryeyeinSjögren’ssyndromehashardlybeenasubjectofdiscussionasitisassumedthatlymphoplasmocyticcellinfiltrationofthetearglanddeterioratesitsfunctiontosuchade...
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Anti-Ro/SSAandanti-La/SSBautoantibodiesinthetearfluidofpatientswithSj?gren’ssyndrome
...fanti-Ro/SSAandanti-La/SSBantibodiesinthetearfluidandserumofpatientswithSj?gren’ssyndromeandtoevaluatetheassociationoftheseautoantibodieswiththeseverityofkeratoconjunctivitissicca.Methods:Tearfluidandserumwereobtainedfrom28patientswithSj?gren’ssyndromeand17agematchednormalcontrolsubjects.Evaluat...
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OralpilocarpineforSj?gren’ssyndrome
Sj?gren’ssyndromeisanautoimmunediseasethataffectsexocrineglandsandcauseskeratoconjunctivitissicca.Ocularcomplicationsincludecornealulceration,episcleritis,keratitis,andbacterialorviralinfection.Theuseofartificialtearsisthemainstayoftreatment.Ithasbeensuggestedthatpilocarpine,acholinergicparasympat...
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Thetreatmentofdryeyes
...,trachoma,andothercausesofsevereconjunctivalcicatrisation.AndthenthereisSj?gren’ssyndrome,ageneralisedinflammatorydiseasethatstandsaloneinitsowncategory.PatientswithSj?gren’ssyndromeusuallyhavedryeyesorKCSbuttheyalsohaveormaynothaveanassociatedrheumatologicaldiseasedependingonwhethertheyhaveprim...
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M3RautoantibodiesmarkoutSj?gren’ssyndrome
JapaneseresearchershavefoundwhatcouldbeanewmarkerforSj?gren’ssyndrome(SS)inautoantibodiestoanantigenexpressedintearandsalivaryglands.Intimeitmaybepossibletodeterminehowthesearelinkedtothedevelopmentofthedisease.Theresearcherslookedfortheautoantibodiesinserumfrom426patientswithoneofarangeofautoimmu...
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儿童干燥综合征的病因和发病机制研究进展
【摘要】干燥综合征(sjgrensyndrome,SS)是一种慢性炎症性的自身免疫性疾病,病变主要为淋巴细胞和浆细胞浸润泪腺和大小唾液腺等外分泌腺体,致使腺体破坏,引起腺体的分泌减少为特点,造成多种临床表现,但以干眼症...
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干燥综合征消化道X线改变的研究
【摘要】目的观察总结干燥综合征消化道X线改变。方法对确诊为干燥综合征的298例患者在胸腹联透后,服钡进行消化道检查。结果总结出辅助与重要X线征象11种。结论认识干燥综合征消化道X线表现有助于提高对该综合征的诊断...
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提高ICD—10编码的准确率,临床医生书写好病历是关键
...遗传性椭圆形红细胞增多症异名:遗传性卵圆形细胞增多综合征,溶血性椭圆形细胞性贫血。是常染色体显性遗传。儿童期发病,不同程度的溶血引起贫血和黄疸。继发感染时贫血加重。肝脾肿大,可出现急性溶血,出现溶血危...
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第三章 皮肤病的免疫学基础
...中出现冷蛋白时称冷球蛋白血症。它在SLE、PSS、SjÖgren综合征、天疱疮、类肉瘤、麻风等都是阳性。尽管抗原抗体各不相同,但是冷球蛋白血症的共同的皮肤改变为四肢未端的发绀、紫癜、坏死雷诺氏现象。 六、变态反应...
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Blood:长江学者吴玉章发表免疫研究新成果
...表达miR-146a,通过下调Fas导致了自身免疫性淋巴细胞增生综合征(autoimmunelymphoproliferativesyndrome,ALPS)。这一研究发现发表在近期的《Blood》杂志上。第三军医大学的长江学者特聘教授吴玉章(YuzhangWu)是这篇论文的通讯作者。其...
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第六节 腮腺
...眼干症状,如合并类风湿性关节炎称为舍格林(Sjōgren)综合征。造影表现为未梢导管扩张,或伴有主导管扩张及充盈缺损,腺体萎缩,腺泡无造影剂充盈。如表现为肿块病变,则不易与腮腺的良恶性肿瘤区别。 二、CT与MRI...
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BotulinumtoxinAtreatmentinpatientssufferingfromblepharospasmanddryeye
...eenreportedafterperiorbitalbotulinumtoxinAinjectionsforpatientswithSjögren’ssyndromeassociatedwithblepharospasm.5BecauseofthereductionoflacrimaldrainageafterbotulinumtoxinAinjections,thistreatmenthasbeensuggestedfordryeyes.6Incontrast,Priceetal2didnotfindanychangesinSchirmertestresults1weekaf...
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长寿果蝇为人类战胜糖尿病开启新路
...突变果蝇能够成为人类了解决定营养和压力如何影响代谢综合症和糖尿病的因素、为何糖尿病会在老年人中发生率高以及人们如何才能活得更久等问题的一个契入口。研究人员创造出的这种果蝇比正常果蝇的寿命长了40%。有关...
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Comparisonofautologousserumeyedropswithconventionaltherapyinarandomisedcontrolledcrossovertrialforocularsurfacedisease
...tswererecruitedwith31eyesstudied.TheocularsurfacediseaseschieflyincludedSj?gren’ssyndrome(n=6)andkeratoconjunctivitissicca(n=5).Impressioncytologyavailablein25of31eyesshowedsignificantimprovementonserumtreatment,p0.02.Raschweightedfacesscoreswerestatisticallysignificantlybetterwithserum,p0.01.Conc...
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Topicalciclosporininthetreatmentofocularsurfacedisorders
....15Moreover,theconjunctivalTcellsubpopulationsdonotdiffersignificantlyinSj?gren’ssyndromeandnon-Sj?gren’ssyndromepatientswithdryeye.16Androgensalsorepresentanimportanttrophicfactorfortheocularsurface,andtheirdeficiencypredisposestoinflammationfrombothlacrimalandmeibomianglanddysfunction.17Immune...
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去势雄兔干眼症模型泪腺组织NFκBp65亚基及NOS2表达
...6,26:81. [5]SULLIVANDA,WICKHAMLA,ROCHAEM,etal.AndrogensanddryeyeinSjgren’ssyndrome[J].AnnNYAcadSci,1999,22:312. [6]尚晔.自体角膜缘干细胞移植治疗翼状胬肉198例分析[J].青岛大学医学院学报,2007,43(6):543. [7]AZUMAM,MOTEGIK,AOTAK,et.al.Roleofcytokinesinthed...
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Neurologicalconcomitantsofuveitis
...rheumatologistonclinicalsigns,thepresenceofautoantibodiesand,inthecaseofSj?gren’ssyndrome,anabnormalsalivaryglandbiopsy.8Cogan’ssyndromewasconfirmedbyanotolaryngologistinpatientswithuveitisandconcurrentinflammationoftheeighthcranialnerve.9AdiagnosisofCNSvasculitiswasbasedoncerebralangiographicab...
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腮腺恶性淋巴瘤
...状腺常与慢性淋巴细胞性甲状腺炎有关,而腮腺常与干燥综合征或肌上皮涎腺炎有关。另有资料表明腮腺在正常情况下也含有粘膜相关淋巴样组织,腮腺MALToma的组织学观察可以发现淋巴上皮病同时存在[3,4]。提示了腮腺粘膜...
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糖尿病专家在长寿果蝇身上找到启发
...路。基因突变的果蝇有助于理解营养和压力如何构成代谢综合症和糖尿病的基础,以及糖尿病的发病为何随着年龄的增长而增加。DirkBohmann和HenriJasper博士正研究应对压力的细胞信号转导系统,以及糖尿病的中心问题-胰岛素受体...
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心理所合作研究发现原发性干燥综合症的新基因
...联研究(GWAS)在7q11.23鉴别出了中国汉族人群原发性干燥综合征(Sjogren\‘ssyndrome,SS)的一个全新易感位点。相关论文于10月6日发表在国际顶级专业期刊《自然遗传学》(NatureGenetics)杂志上。北京协和医院风湿免疫科的张奉春(Fe...
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Postprandialresponsesofindividualfattyacidsinsubjectshomozygousforthethreonine-oralanine-encodingalleleincodon54oftheintestinalfattyacid
JyrkiJÅgren,HelviMVidgren,RaisaSValve,MarkkuLaaksoandMattiIUusitupa1FromtheDepartmentsofPhysiology,ClinicalNutrition,andMedicine,UniversityofKuopio,Kuopio,Finland.2AddressreprintrequeststoJJÅgren,DepartmentofPhysiology,UniversityofKuopio,POBox1627,70211Kuopio,Finland.E-mail:jyrki.agren{a...
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原发性干燥综合征的临床分析
【摘要】目的了解广东地区原发性干燥综合征(PSS)患病情况的临床特点。方法回顾性研究1993~2003年我院收治的的23例PSS患者的临床资料。结果广东地区PSS的患病率较低,口干、眼干症状较轻。结论PSS的患病情况存在地区性差...
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中国学者完成川金丝猴基因组测序
...aoqingSun,ZhijinLiu,HuijuanPan,YuLin,GuangjianLiu,WeiZhan,MingzhouLi,BaopingRen,XingyongMa,HangRuan,ChenCheng,DaweiWang,FangleiShi,YuanyuanHui,YujingTao,ChenglinZhang,PingfenZhu,ZuofuXiang,WenkaiJiang,JiangChang,HailongWang,ZhishengCao,ZhiJiang,BaoguoLi,GuangYang,ChristianRoos,PaulAGarber,MichaelWBr...
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Eveningprimroseoilandborageoilinrheumatologicconditions
...149;borageoilrheumatoidarthritisRaynaudphenomenonSjögrensyndromedihomo--linolenicacidINTRODUCTIONEicosanoidformationTheessentialfattyacids(EFAs)haveuniquerolesasprecursormoleculesofchemicalregulatorsofinflammatorycellfunction(1).Theseregulatorsaretheprostaglandins(PGs)an...
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中国科大举办“中国-北欧分子生物及纳米科学会议”
...ickNorman教授和LarsOjamauml;e教授,瑞典皇家工学院的HansAring;gren教授、ToreBrinck教授、ZilvinasRinkevicius副教授、YingFu副教授和MartenAhlquist副教授,瑞典斯德哥尔摩大学的AattoLaaksonen教授、MargaretaBlomberg教授、FahmiHimo教授、LarsPettersson教授...
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几种常见自身免疫病外周血γ/δT细胞的表达
...12名正常对照、24例系统性红斑狼疮(SLE)、12例原发性干燥综合征(pSS)、14例类风湿关节炎(RA)以及10例白塞病患者的外周血中总γ/δ、Vγ1和Vγ9/Vδ2细胞的表达情况进行流式细胞仪分析。结果 SLE活动期患者的总γ/δ、Vγ1和Vγ9/Vδ2T细...
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SolubleBAFFAntagonistBR-FcDecreasesPeripheralBloodBCellsandLymphoidTissueMarginalZoneandFollicularBCellsinCynomolgusMonkeys
...essuchasrheumatoidarthritis(RA),systemiclupuserythematosus(SLE),andSjögren??ssyndrome.26-29InpatientswithRA,BAFFlevelsinsynovialfluidshowevengreaterelevationsthantheydoinserum.26,30Intransgenicmice,overexpressionofBAFFleadstotheexpansionofmarginalzoneBcells,acelltypeimplicatedinautoimmunity.31F...
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“霍比特人”传奇:发现十年争议未断
...新的认识,它真是个让人抓狂的东西。如果它患了莱伦氏综合征、呆小症或者是其他一些假设病症,而我们在它身上花费了那么多心血,那就太不幸了。现在“霍比特团队还在继续发掘梁布亚,随着新工作的推进,研究人员...