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肝细胞端粒缩短与染色体不稳定性和人肝细胞瘤的发生相关
(HEPATOLOGY2004;40:80-86)肿瘤发生的端粒假说提示,端粒缩短能够通过诱导染色体不稳定性引发肿瘤。为检测这一假说能否应用于人肝细胞癌(HCC),德国汉诺威医学院的K.LenhardRudolph博士及其同事对肝硬化患者(39例)的肝脏肿瘤...
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多伦多华裔研究员解开早产之谜有助于有效预防
据香港媒体报道,多伦多西乃山医院华裔研究员董学森(XuesenDong,译音)发现导致早产及流产因素,将有助了解如何防止流产及早产。他将于今日在美国新奥尔良市召开的内分泌协会第86届年会上,宣布这项发现。报道说,从统计...
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肝细胞端粒缩短与染色体不稳定性和人肝细胞瘤的发生相关
(HEPATOLOGY2004;40:80-86)肿瘤发生的端粒假说提示,端粒缩短能够通过诱导染色体不稳定性引发肿瘤。为检测这一假说能否应用于人肝细胞癌(HCC),德国汉诺威医学院的K.LenhardRudolph博士及其同事对肝硬化患者(39例)的肝脏肿瘤...
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进行经动脉化学栓塞的肝细胞癌患者发生急性肾衰的发病率和危险因素
(LiverInt,2004;24(3):210-215)经动脉化学栓塞(TACE)是肝细胞癌(HCC)的有效治疗措施,但是用于TACE的大量放射性对比剂能够造成肾功能障碍。1.5mg/dl)的发病率和危险因素。在进行TACE的140例患者中,12例(8.6%)发生ARF。单变量分...
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发生1型肝肾综合征的肝硬化患者采用内科药物治疗与TIPS治疗的效果
(HEPATOLOGY2004;40:55-64)发表在最新一期肝脏病学杂志上的一项研究表明,一些肝硬化腹水患者在通过米多君、奥曲肽、白蛋白等药物联合治疗改善肾功能后,能够有效地采用TIPS进行治疗。加拿大多伦多综合医院的FlorenceWong博士指...
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IdentificationofClinicallyRelevantViridansStreptococcibyanOligonucleotideArray
...ifymoremicroorganisms.ACKNOWLEDGMENTSThisprojectwassupportedbygrants(NSC93-2323-B006-007andNSC93-2323-B006-006)fromtheNationalScienceCounciland,inpart,bygrantsfromtheDepartmentofMedicalResearchoftheNationalTaiwanUniversityHospital,Taipei,Taiwan.REFERENCESAdamczyk,J.,M.Hesselsoe,N.Iversen,M.Horn,A.Le...
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Noaudiblewheezing:nuggetsandconundrumsfrommouseasthmamodels
...ryresponsestobronchoconstrictoragonistsinthemouse.J.Appl.Physiol.64:2318–2323.DeSanctis,G.T.,M.Merchant,D.R.Beier,R.D.Dredge,J.K.Grobholz,T.R.Martin,E.S.Lander,andJ.M.Drazen.1995.QuantitativelocusanalysisofairwayhyperresponsivenessinA/JandC57BL/6Jmice.Nat.Genet.11:150–154.Hadeiba,H.,D.B.Corry,an...
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孕三烯酮
...名称孕三烯酮药物别名三烯高诺酮,18-甲三烯炔诺酮,R2323,Methylnorgestrienone英文名称Gestrinone说 明片剂,每片1.5mg;2.5mg。功用作用为中等强度孕激素,具有较强的抗孕激素和抗雌激素活性,亦有很弱的雌激素和雄激素作用。...
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招远市农村育龄夫妇查体ALT检测结果分析
...前免费查体夫妇4597人(年龄22~45岁),其中男性2274人,女性2323人。 1.2仪器与试剂迈瑞BS-200全自动生化分析仪(深圳迈瑞公司),ALT试剂盒(深圳迈瑞公司)。 1.3检验对象的准备空腹8h后静脉采血,待凝固后分离出血清待测。 ...
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C-ReactiveProtein,FibrinD-Dimer,andRiskofIschemicHeartDisease
...coronaryheartdisease:prospectivestudyandmeta-analysis.Circulation.2001;103:2323–2327.RitchieDG,LevyBA,AdamsMA,FullerGM.Regulationoffibrinogenandfibrin:anindirectfeedbackpathway.ProcNatlAcadSciUSA.1982;79:1530–1534.EdgingtonTS,CurtissLK,PlowEG.Alinkagebetweenthehaemostaticandimmunesystemsembodied...
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附表3t值表
...6762.0092.4032.6782.9373.2613.49660 0.6791.2961.6712.0002.3902.6602.9153.2323.46070 0.6781.2941.6671.9942.3812.6482.8993.2113.43680 0.6781.2921.6641.9902.3742.6392.8873.1953.41690 0.6771.2911.6621.9872.3682.6322.8783.1833.402100 0.6771.2901.6601.9842.3642.6262.8713.1743.390200 0.6761.286...
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幽门螺杆菌阳性慢性胃炎的临床病理特征
...4)n%n%上腹痛6464.64864.9上腹胀满2525.31824.3嗳气1616.21216.2反酸2323.21723.0烧心1717.21418.9食欲差1414.11216.2恶心1212.11114.9上腹不适88.179.5 各种消化不良症状的发生率在Hp阳性与Hp阴性两组病人之间差异均无显著性(表1)。血清基础胃泌...
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Granulocyte-MacrophageColonyeCStimulatingFactorandLungImmunityinPulmonaryAlveolarProteinosis
...cificbiologictherapyinpatientswithlungmetastases.ClinCancerRes1999;5:2316eC2323.IyonagaK,SugaM,YamamotoT,IchiyasuH,MiyakawaH,AndoM.ElevatedbronchoalveolarconcentrationsofMCP-1inpatientswithpulmonaryalveolarproteinosis.EurRespirJ1999;14:383eC389.SeymourJF,DoyleIR,NakataK,PresneillJJ,SchochOD,HamanoE,...
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Doeswaistcircumferencealoneexplainobesity-relatedhealthrisk?
...theentireDanishpopulationinthisagegroup.Fromrecruitmentuntil31December2002,2323deaths(1461menand862women)wereidentifiedintheCivilRegistrationSystembyusingtheuniquepersonalidentificationnumbersassignedtoallDanishinhabitants.Missinginformationaboutvariablesofinterestledtotheexclusionof628participants,...
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分子靶向药物Pazopanib治疗转移性肾癌的效果观察
...edagentsforthetreatmentofadvancedrenalcellcarcinoma[J].Cancer,2005,104(11):23232333. [8]SonpavdeG,HutsonTE.Pazopanib:anovelmultitargetedtyrosinekinaseinhibitor[J].CurrOncolRep,2007,9(2):115119. [9]HutsonTE,SonpavdeG,GalskyMD.Targetinggrowthfactorandantiangiogenicpathwaysinclearcel...
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OptimizedDiagnosisofAcuteDengueFeverinSwedishTravelersbyaCombinationofReverseTranscription-PCRandImmunoglobulinMDetection
...andyellowfevervirusbyreal-timereversetranscription-PCR.J.Clin.Microbiol.40:2323-2330.Gubler,D.J.1998.Dengueanddenguehemorrhagicfever.Clin.Microbiol.Rev.11:480-496.Gubler,D.J.2002.Theglobalemergence/resurgenceofarboviraldiseasesaspublichealthproblems.Arch.Med.Res.33:330-342.Guzman,M.G.,andG.Kouri.200...
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Interleukin-6,FibrinD-Dimer,andCoagulationFactorsVIIandXIIainPredictionofCoronaryHeartDisease
...coronaryheartdisease:prospectivestudyandmeta-analysis.Circulation.2001;103:2323–2327.LoweGDO,YarnellJWG,RumleyA,BaintonD,SweetnamPM.C-reactiveprotein,fibrinD-dimerandincidentischaemicheartdiseaseintheSpeedwellStudy.Areinflammationandfibrinturnoverlinkedinpathogenesis?ArteriosclerThrombVascBiol.200...
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糖耐量低减患者血清炎症因子的相关性研究
...bjectswithimpairedglucosetolerance[J].Di-abetesCare,2003,26(8):2323~2328. [6]FestaA,D(AgostinoRJ,MykkanenLetal.RelativecontributionofinsulinanditsprecursorstofibrinogenandPAI-1inalargepopulationwithdif-ferentstatesofglucosetolerance.TheinsulinResistanceAtherosclerosisStu...
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AssociationsofInflammatoryandHemostaticVariablesWiththeRiskofRecurrentStroke
...coronaryheartdisease:prospectivestudyandmeta-analysis.Circulation.2001;103:2323–2327.LoweGDO,DaneshJ,LewingtonS,WalkerM,LennonL,ThomsonA,RumleyA,WhincupPH.Tissueplasminogenactivatorantigenandcoronaryheartdisease:prospectivestudyandmeta-analysis.EurHeartJ.2004;25:252–259.GusseklooJ,SchaapMCL,Frol...
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抗生素中药引发不良反应多
...不良反应监测中心获悉,去年天津市共报告药品不良反应2323例,比2005年增加了2.56倍,每百万人口平均报告227例。市药品不良反应监测中心主任宋立刚表示,抗生素、中药引起的不良反应仍然位居不良反应报告前两位,但调查显...
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开放性骨折早期处理
...尔骨科手术学.第9版.济南:山东科学技术出版社,2001,2:2323-2330.3刘大雄.开放性骨折内固定治疗中的几个问题.骨与关节损伤杂志,2003,18(3):145.4HelfetDL,HoweyT,SandersR,JohansenK.ClinOrthop,1990,80:256.作者单位:400050重庆市巫溪县人...
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Overexpressionofkidneyneutralendopeptidase(EC3.4.24.11)andrenalfunctioninexperimentalcirrhosis
...eptidasecausesvasoconstrictionofhumanresistancevesselsinvivo.Circulation97:2323-2330,1998.FyhrquistF,TottermanKJ,andTikkanenI.Infusionofatrialnatriureticpeptideinlivercirrhosiswithascites.Lancet2:1439,1985.GarvinJL.InhibitionofJvbyANFinratproximalstraighttubulesrequiresangiotensin.AmJPhysiolRenalFlu...
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PCRAnalysisofEgyptianRespiratoryAdenovirusIsolates,IncludingIdentificationofSpecies,Serotypes,andCoinfections
...virusstrainsofserotype7collectedovera7-yearperiod.J.Clin.Microbiol.32:2321-2323.Kajon,A.E.,S.A.R.Portes,W.A.deMello,J.P.Nascimento,andM.M.Siqueira.1999.GenometypeanalysisofBrazilianadenovirusstrainsofserotypes1,2,3,5,and7collectedbetween1976and1995.J.Med.Virol.58:408-412.Kajon,A.E.,A.S.Mistchenko,C....
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InvolvementofguanylylcyclaseandcGMPintheregulationofMrp2-mediatedtransportintheproximaltubule
...nAandFK506-inducedapoptosisinrenalproximaltubulecells.JAmSocNephrol11:2315-2323,2000.HosogaiN,SekiJ,andGotoT.ReciprocalregulationofcyclicGMPcontentbycyclicGMP-phosphodiesteraseandguanylatecyclaseinSHRwithCsA-inducednephrotoxicity.BrJPharmacol134:995-1002,2001.JedlitschkyG,BurchellB,andKepplerD.Themu...
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SerumAdipocyteFattyAcid-BindingProteinLevelsWereIndependentlyAssociatedWithCarotidAtherosclerosis
...glycemiainChinesesubjectswithimpairedglucosetolerance.DiabetesCare.2003;26:2323-2328.MatthewsDR,HoskerJP,RudenskiAS,NaylorBA,TreacherDF,andTurnerRC.Homeostasismodelassessment:insulinresistanceandbeta-cellfunctionfromfastingplasmaglucoseandinsulinconcentrationsinman.Diabetologia.1985;28:412-419.XuA,C...
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NOD.c3c4congenicmicedevelopautoimmunebiliarydiseasethatserologicallyandpathogeneticallymodelshumanprimarybiliarycirrhosis
...immunebiliarydiseaseinanonobesediabeticcongenicstrain.J.Immunol.173:2315–2323.Bach,J.F.,andD.Mathis.1997.TheNODmouse.Res.Immunol.148:285–286.Rasooly,L.,C.L.Burek,andN.R.Rose.1996.Iodine-inducedautoimmunethyroiditisinNOD-H-2h4mice.Clin.Immunol.Immunopathol.81:287–292.Cha,S.,H.Nagashima,V.B.Brow...
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专注开发原创药的安进决定把“抄袭”做到完美
...)仿制药的工作正在进行中。在这个2.5万平方英尺(约合2323平方米)的平台上,摆满了2000升容量的铁罐,每一个都带有仪表盘、按钮和突出的管道。这里正是安进公司用来生产自家的生物制药以及仿制其他药企药品的地方。2010...
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高效液相色谱法在脱蛋白天然胶乳研究中的应用
...e(苯丙氨酸)2728.7Lys(赖氨酸)5953.8His(组氨酸)1717.7Arg(精氨酸)2323.3*以丙氨酸的文献值为参比(Alaofliteraturevalueusedasrefe-rence)2.2方法的应用 采用优选的分析条件对经酶法脱蛋白处理过的胶乳膜片和未经处理的胶乳膜片中的可溶性...
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RAGElimitsregenerationaftermassiveliverinjurybycoordinatedsuppressionofTNF-andNF-B
...r:identificationandcharacterizationoffourdistinctpopulations.J.Immunol.170:2323–2330.Chen,Y.,S.S.Yan,J.Colgan,H.P.Zhang,J.Luban,A.M.Schmidt,D.Stern,andK.C.Herold.2004.Blockadeoflatestagesofautoimmunediabetesbyinhibitionofthereceptorforadvancedglycationendproducts.J.Immunol.173:1399–1405.Zeng,S.,...
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GenomicApproachtoIdentificationofMycobacteriumbovisDiagnosticAntigensinCattle
...roteinsofMycobacteriumtuberculosisbyabioinformaticapproach.Infect.Immun.68:2323-2327.Gordon,S.V.,R.Brosch,A.Billault,T.Garnier,K.Eiglmeier,andS.T.Cole.1999.Identificationofvariableregionsinthegenomesoftuberclebacilliwithbacterialartificialchromosomearrays.Mol.Microbiol.32:643-655.Grosse,W.M.,S.M.Kap...