-
PKCδ诱导的细胞凋亡相关蛋白研究进展
...杂,相关蛋白种类繁多,除常见的caspase家族以外,p53、PLS-3、拓扑异构酶、Mcl-1等蛋白也参与了PKCδ对凋亡的调节过程。【关键词】PKCδ;凋亡;p53;PLS-3蛋白激酶C(PKC)是一类由多种同工酶组成的丝/苏氨酸蛋白激酶家族,处于...
-
东北地理所等水体藻清蛋白和叶绿素遥感估算研究获进展
...纳波利斯校区李林教授进行合作,开发了自适应智能算法PLS-ANN(PartialLeastSquares-ArtificialNeuralNetworks),对内陆重要湖泊和城市水源地的Chl-a和PC进行了遥感算法研究[1-2]。研究结果表明PLS所选取的波段与波段比值算法、半解析模型...
-
原发性脾脏恶性淋巴瘤21例的临床分析
...oma;splenectomy原发性脾脏恶性淋巴瘤(primarylymphomaofthespleen,PLS)临床少见,自1931年Krumhbar首次报道以来国内外鲜有大宗病例报道,本文总结我院1975~2000年21例PLS患者的临床资料,探讨其临床表现及病理特征与手术治疗效果。1资料...
-
更抗逆酵母的秘诀——脯氨酸和肌醇提高酵母抑制物耐受能力
...产物测定汇总,获得了代谢组学数据。研究人员首先执行PLS判别分析(PLS-DA),发现抗逆菌株主要代谢产物类别同出发菌株具有明显的不同,暗示菌株通过调节自身代谢反应适应逆境。利用特征选择方法(mRMR),研究人员确定...
-
基于最小二乘支持向量机的色谱指纹谱预测银杏叶总抗氧化活性
...自由基能力组成的训练集和测试集,分别建立了BPNN、PLS与LSSVM模型。为了与LSSVM直观比较,神经网络的输入即为5580个输入变量(色谱图长度),输出为清除自由基能力,采用目前应用最广的3层BPNN,网络中的隐含层神经元...
-
Effectofalow-fatdietonfattyacidcompositioninredcells,plasmaphospholipids,andcholesterolesters:investigationofabiomarkeroftotalfatintak
...isunknown.Objective:WecomparedFAchangesinredcells(RCs),plasmaphospholipids(PLs),andcholesterolesters(CEs)inresponsetoalow-fatdiet(LFD)andamoderate-fatdiet(MFD)andassessedwhetherindividualorcombinationofFAspredictLFD.Design:Postmenopausalwomen(n=66)wererandomlyassignedtoreceiveanLFD(17%ofenergyfromfa...
-
TheplsGeneFoundinMethicillin-ResistantStaphylococcusaureusStrainsIsCommoninClinicalIsolatesofStaphylococcussciuri
...rtmentofMicrobiology,NationalPublicHealthInstitute,Helsinki,FinlandABSTRACTpls,agenefoundintypeIstaphylococcalcassettechromosomemec(SCCmec)regionsofmethicillin-resistantStaphylococcusaureusstrains,waspresentin12ofthe15humanclinicalStaphylococcussciuriisolatesstudied.PlswasexpressedintheS.sciuriisola...
-
Thelowfatparadoxdodietarycarbohydratesincreasecirculatingsaturatedfattyacids?
...nmyristicacid(14:0),palmiticacid(16:0),andtotalsaturatesinthephospholipids(PLs)andcholesterylester(CE)fractionsinresponsetoalow-fat(17%ofenergy),high-carbohydratediet.Alsoofinterestinthisreportisthelackofdataquantitatingthetotalserumtriacylglycerolfractionanditsfattyacidcomposition.Giventhegreatinte...
-
比较分子力场分析法研究苯基烷胺类致幻剂的定量构效关系
...与分子之间的立体场能和静电场能,运用偏最小二乘法(PLS)寻找最佳主成分数建立预测模型。并将结果以直观的三维图形方式表示出来。由于CoMFA充分考虑了分子的三维结构和药物与受体的结合模式,在合理药物设计工作方面...
-
Influenceofacutephytochemicalintakeonhumanurinarymetabolomicprofiles
...andexposeanytrendsoroutlyingdata.Partialleast-squares-discriminantanalysis(PLS-DA)wasthenperformedtodefinethemaximumseparationbetweentheLPDversustheNDorthestandardSPD.Thedatawerevisualizedbyconstructingprincipalcomponentscoresandloadingsplots,whereeachpointonthescoreplotrepresentedanindividualurines...
-
CompleteRescueofLipoproteinLipase–DeficientMicebySomaticGeneTransferoftheNaturallyOccurringLPLS447XBeneficialMutation
...mmt.ubc.caAbstractThenaturallyoccurringhumanlipoproteinlipaseS447Xvariant(LPLS447X)exemplifiesagain-offunctionmutationwithsignificantbenefitsincludingdecreasedplasmatriglycerides(TG),increasedhigh-densitylipoprotein(HDL)cholesterol,andreducedriskofcoronaryarterydisease.TheS447Xvariantmaybeassociated...
-
手助腹腔镜联合手术2例报告
...切割缝合器等);常规腹腔镜手术(PureLaˉparoscopicSurgry,PLS)下缺乏触觉功能,不利于对病变处进行探查,也不利于术中解剖分离、止血等精细操作,增加了术中邻近器官损伤的可能性;腹腔镜大器官切除多需在腹壁上切开约6cm长...
-
第二节 附临床检验正常参考值
...~30mg/dl神经鞘磷脂S,P0.1~0.5g/L1010~50mg/dl磷脂Phospholipid PLS以P×25计1.6~3.9g/L0.013130~250mg/dl总胆固醇TotalcholesterolTCHS 儿童成人3.12~5.20mmol/L2.9~6.0mmol/L0.0260.026120~200mg/dl110~230mg/dl胆固醇酯ChloesterolesterCES占胆固醇总量70~75%-同...
-
聚焦2005年ECC及CPR治疗推荐国际会议
...急救医学的国际科学知识提供一种机制,用以就急救BLS、PLS、ALS提供一致的国际指南。其主要聚焦点是应用指南,也强调训练、教学、急救医学组织实施。ILCOR目标在共同的科学支持下发展国际复苏指南ILCOR目的为世界范围内心...
-
六味地黄丸含量测定方法
...光谱法测定六味地黄丸中丹皮酚,分别采用偏最小二乘(PLS)、主成分分析-BP神经网络、小波变换-BP神经网络对所采集的样本数据进行处理。完茂林等测定六味地黄丸中丹皮酚的含量,采用毛细管气相色谱法,以正十六烷为内标。日...
-
高效液相色谱测定六味地黄丸的含量
...外光谱法测定六味地黄丸中丹皮酚,分别采用偏最小二乘PLS、主成分分析-BP神经网络、小波变换-BP神经网络对所采集的样本数据进行处理。完茂林等测定六味地黄丸中丹皮酚的含量,采用毛细管气相色谱法,以正十六烷为内标。...
-
1例过敏性休克应用体外膜肺氧合的护理
...Cl-107mmol/L,ABE-17.3mmol/L,Glu19.2mmol/L。 患儿采用MAQUETBE-PLS2050膜肺,Jostra离心泵,采用动脉-静脉(A-V)模式,左股动脉切开予16Fr插管,右颈静脉切开予20Fr插管。持续应用肝素,血流量2.5L/min,氧气流量为2.5L/min,FiO270%~80%。ECMO运...
-
口腔健康教育对Ⅱ型糖尿病患者牙周病影响的观察
...究结果一致[4-6]。但研究组在基础治疗后3个月、6个月PLs与基线比仍有明显差异,对照组在基础治疗后3个月、6个月PIs均与基线无明显差异,提示口腔健康教育对Ⅱ型糖尿病患者牙周病的治疗是必要的,其可以有效地维持牙周...
-
第四节 遗传多态现象
...即慢(S)、中(I)、快(F)型,它们受3个复等位基因PLs、PLi及PLf控制,每种基因分别编码S、I、F三种同工酶(G6PD)和腺苷酸激酸(AK)的同工酶即属此类。 (3)翻译后同工酶:酶蛋白翻译产物经不同修饰反应也可产生不...
-
心肺复苏后伴多器官功能障碍患者的监测与护理
...《国际心肺复苏和心血管急救指南2000》推荐的BLS、ACLS、PLS原则进行操作[2]。胸外按压,电复律,常规剂量逐次静脉给肾上腺素及其他药物进行心肺复苏,纠正心律失常,经口或鼻气管插管、气管切开进行机械通气,应用纳洛...
-
口腔遗传疾病的遗传方式及其临床表现
...reperiodontaldestructionofteethsyndrome)又称Papillon-Lefèvre综合征(PLS),本病为常染色体隐性遗传,掌跖角化与角质素基因突变有关。有人称为类牙周炎变性病。临床表现:手掌和足跖部皮肤过度角化,多为弥漫型,早年牙周病(4岁前...
-
ProteochemometricMappingoftheInteractionofOrganicCompoundswithMelanocortinReceptorSubtypes
...relationwasperformedusingpartialleast-squaresprojectionstolatentstructures;PLS).Awellfittedmathematicalmodel(R2=0.92)withhighpredictiveability(Q2=0.79)wasobtained.Inafurthervalidationofthemodel,thepredictiveabilityforligands(Q2lig=0.68)andreceptors(Q2rec=0.76)wasestimated.Themodelwasmoreovervalidate...
-
一氧化氮及其合酶在杀伤肿瘤细胞中的作用肝细胞线粒体与肝硬化
...,嵴消失基质浓缩。此外,Bigatello等发现肝性脑病者血清PLS水平显著高于代偿性肝硬化患者,深昏迷者明显高于浅昏迷者,证明内毒素血症肝性脑病关系密切。有研究认为:LPS损害线粒体的氧化代谢,可以减少肝硬化患者对氧的...
-
HumanPregnaneXReceptorAntagonistsandAgonistsDefineMolecularRequirementsforDifferentBindingSites
...vityrelationship(QSAR)model,usingVolSurfdescriptorsandpartialleast-squares(PLS),thatidentifiedhydrogenbondacceptorregionsandamideresponsiveregionswasdescribedfor33PXRligands,althoughnotestsetdatawereprovided(Jacobs,2004).Asecondstatisticalmodelusingarecursivepartitioningmethodhasbeenusedwith99PXRact...
-
Effectofacutedietarystandardizationontheurinary,plasma,andsalivarymetabolomicprofilesofhealthyhumans
...mpleswasthenfurtherexploredbyusingpartialleast-squaresdiscriminantanalysis(PLS-DA),asuperviseddataanalysistechnique.TotestthePLS-DAmodeldescribingdiurnalvariation,across-validationstepwascarriedoutbyusingatrainingsetconstructedfrom50%ofthesamples.Thistrainingsetwasusedtodetermineclassmembership(nigh...
-
IntermittentHypoxiaInducesHyperlipidemiainLeanMice
...lsoftotalcholesterol,high-densitylipoprotein(HDL)cholesterol,phospholipids(PLs),andtriglycerides(TGs),aswellasliverTGcontent.Thesechangeswerenotobservedinobesemice,whichhadhyperlipidemiaandfattyliveratbaseline.Inleanmice,IHincreasedsterolregulatoryelementbindingprotein1(SREBP-1)levelsintheliver,incr...
-
DeficiencyofCfromDonororRecipientMouseFailstoPreventRenalAllograftRejection
...andC9-positivestainingwasquantifiedusingLuciaimageanalysissoftware(Jencons-PLS,ForestRow,UK).Atamagnificationofx400,foreachanimal,sixfieldsfromtwostainedkidneysectionswerephotographed.Areasofpositivestainingineachimagewereoutlined,highlighted,andvaluescomputed.FlowCytometryThepresenceofcirculatingdo...
-
Fattyacidsaturationofthedietandplasmalipidconcentrations,lipoproteinparticleconcentrations,andcholesteroleffluxcapacity
...ewthistable:TABLE2.Effectofdietsonfattyacidcompositionofserumphospholipids(PLs)andcholesterolesters(CEs)1LipidandlipoproteinprofileLipidandlipoproteinparticleprofiles(Table3)wereanalyzedforeachsexindependentlybecausethecholesteroleffluxanalysisshowedasignificantinteractionbetweensexandtheresponsesob...
-
运动神经元病的病因研究及诊疗现状
...髓的下运动神经核和原发性侧索硬化(primarylateralselerosis,PLS),选择性地损害锥体束[2]。病情呈慢性进行性发展,从症状表现开始,平均存活期仅为3~5年,多发生在老年期及老年前期,平均发病年龄为61岁,多为散发性,10%为家族...
-
AnalogsofMethyllycaconitineasNovelNoncompetitiveInhibitorsofNicotinicReceptors:PharmacologicalCharacterization,ComputationalModeling,andPharmac
...CramerRD3rd(1993)Theprobabilityofchancecorrelationusingpartialleastsquares(PLS).QuantStructActRelat12:137-145.[CrossRef]CramerRD,PattersonDE,andBunceJD(1988)Comparativemolecularfieldanalysis(CoMFA).1.Effectofshapeonbindingofsteroidstocarrierproteins.JAmChemSoc110:5959-5967.[CrossRef]DalyJW(2005)Nico...