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阿霉素小鼠肾病模型的建立及IL18结合蛋白干预的实验研究
...鼠30只,随机分为正常对照组、阿霉素肾病造模组(ADRMCN组)、IL18结合蛋白治疗组(IL18BP治疗组)3组,用阿霉素7.5mg/kg尾静脉注射进行造模,治疗组于第5、7、12、21天腹腔注射0.5mg/kg剂量mIL18BP(鼠源性IL18结合蛋白)...
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Structure-FunctionStudiesofAllostericAgonismatM2MuscarinicAcetylcholineReceptors
...nists4-I-[3-chlorophenyl]carbamoyloxy)-2-butynyltrimethylammnoniumchloride(McN-A-343),4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]piperidinehydrogenchloride(AC-42),andthenovelAC-42derivative1-[3-(4-butyl-1-piperidinyl)propyl]-3,4-dihydro-2(1H)-quinolinone(77-LH-28-1)demonstratedanincreasedaffinity...
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对于64例胰腺囊性肿瘤的体制性研究
...瘤(IPMN),12例浆液性囊性肿瘤(SCN),11例粘液性囊性肿瘤(MCN),11例实性-假乳头状肿瘤(SPN)以及2例囊性变性的实体瘤,通过免疫组织化学检测MUC1,MUC2,MUC4,MUC5AC,MUC6以及其他相关抗原的表达。结果可见,IPMN和交界区域的腺瘤类型MUC2和...
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PNAS:诊断胰腺囊肿的新方法
...乳头状瘤(IPMN)、浆液性囊腺瘤(SCA),粘液性囊肿(MCN)和假乳头状实体瘤(SPN)进行了研究。结果发现每一类型的囊肿都有其特异性的基因改变:SCA的3号染色体片段丢失,破坏了抑癌基因VHL的活性;MCN的生长驱动癌基因KRAS...
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HIV和妊娠:护理实践上的考虑
2006年08月17日MCN-THEAMERICANJOURNALOFMATERNAL-CHILDNURSING31(4):233-240JUL-AUG200615在美国,患上HIV的育龄妇女的数目在不断的增多。妇女也常常在怀孕后检查中才得知自己患上了HIV。自从1981年这种疾病被确认以来,在对其的治疗手段上已经有...
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TheOphthalmologyExaminationsReview
UniversityofCalifornia,SanFrancisco,CA,USA;dfrase@mcn.orgByTienYinWong.Pp448;$84.Singapore:WorldScientificPublishing,2001.ISBN9810243995Preparingforpostgraduateexaminationsisnowanearlyuniversaleventforophthalmologistsintraining.Inmanycountriesitwillbecomeapartofapractisingophthalmologist’sprofessi...
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MiniNutritionalAssessment(MNA):ResearchandPracticeintheElderly
...nVanderbiltCenterforHumanNutrition,VanderbiltUniversityMedicalCenter,C2104,MCN,Nashville,TN37215E-mail:gordon.jensen{at}mcmail.vanderbilt.eduNestleNutritionWorkshopSeriesClinicalPerformanceProgramme,volume1,editedbyBrunoVellas,PhilipJGarvey,andYvesGuigoz,1999,195pages,hardcover,$137.50.SKargerAG,Bas...
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Lowerserumalbuminconcentrationandchangeinmusclemass:theHealth,AgingandBodyCompositionStudy
...reventionSciencesGroup,UniversityofCalifornia,SanFrancisco,SanFrancisco,CA(MCN);theNationalInstituteonAging,LaboratoryofEpidemiology,DemographyandBiometry,Bethesda,MD(TBH)2SupportedbyNationalInstituteonAgingcontractsNO1-AG-6-2101,NO1-AG-6-2103,andNO1-AG-6-2106.TheresearchofMVwasmadepossiblebyafellow...
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功能性弱视3例疗效观察
...1周,因学习紧张后出现,查远视力右0.4,左0.4;近视力右Jr6,左Jr6。例2,男,11岁,双眼视力下降2周,因感冒发烧后出现,查远视力右1.2,左0.4;近视力右Jr1,左Jr7。例3,女,25岁,因车祸左眼视力逐渐下降1个月,1个月前因车祸...
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中浆激光治疗后并发脉络膜新生血管1例
...视物发暗变形2个月,来我院眼科就诊,眼部检查:R0.3,Jr5;L1.0,Jr3,眼压正常,右眼前节未见异常,眼底检查:视乳头色清,黄斑颞上方见1.5PD水肿区,其内见一约1/6PD大小黄白色病灶,水肿波及中心凹,周边视网膜未见异常...
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High-DensityLipoproteins:ANewPotentialTherapeuticTargetforthePreventionofCardiovascularDisease
...inpatientswithaveragecholesterollevels.NEnglJMed.1996;335:1001–1009.DownsJR,ClearfieldM,WeisS,WhitneyE,ShapiroDR,BeerePA,LangendorferA,SteinEA,KruyerW,GottoAMJ.Primarypreventionofacutecoronaryeventswithlovastatininmenandwomenwithaveragecholesterollevels:resultsofAFCAPS/TexCAPS.AirForce/TexasCorona...
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应用于帕金森症药物治疗的新型纳米技术
...。Ngwuluka等人使用的甲基丙烯酸酯共聚物-脂质纳米颗粒(MCN)系统来递送口服左旋多巴。这种纳米粒子是采用多交联技术制成的,并且具有多个属性,研究人员发现他们的纳米粒子可以持续的释放左旋多巴,并认为这种运载系统...
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反向导丝开通RCACTO病变(CIT2007CTO-CLUB转播病例1)
...L4.07Fr指引导管;右冠AL1.07Fr指引导管不能取得同轴,改用JR4.07Fr指引导管2.首选逆向技术:以微导管支撑,送Finecross导丝沿JL指引导管经第1间隔支进入右冠并通过大部闭塞段,但不能通过闭塞段近端3.沿JR指引导管更换6种导丝...
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PolyphasicCharacterizationRevealsthattheHumanPathogenMycobacteriumperegrinumTypeIIBelongstotheBovinePathogenSpeciesMycobacteriumsenegalense
...z,B.Rodriguez-Salgado,K.C.Jost,S.H.Chiu,G.O.Onyi,E.C.Bttger,andR.J.Wallace,Jr.1999.Mycobacteriumwolinskyisp.nov.andMycobacteriumgoodiisp.nov.,twonewrapidlygrowingspeciesrelatedtoMycobacteriumsmegmatisandassociatedwithhumanwoundinfections:acooperativestudyfromtheInternationalWorkingGrouponMycobacteri...
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GeographicDiversityamongGenotypesofEntamoebahistolyticaFieldIsolates
...iol.33:327-337.Ayeh-Kumi,P.F.,I.M.Ali,L.A.Lockhart,C.A.Gilchrist,W.A.Petri,Jr.,andR.Hague.2001.Entamoebahistolytica:geneticdiversityofclinicalisolatesfromBangladeshasdemonstratedbypolymorphismsintheserine-richgene.Exp.Parasitol.99:80-88.Blessmann,J.,L.P.Van,P.A.Nu,H.D.Thi,B.Muller-Myhsok,H.Buss,andE...
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Sepsis-InducedCoagulationintheBaboonLungIsAssociatedwithDecreasedTissueFactorPathwayInhibitor
...dosiCA:Blockadeoftissuefactor:treatmentfororganinjuryinestablishedsepsis.AmJRespirCritCareMed2003,167:1200-1209CrawleyJ,LupuF,WestmuckettAD,SeversNJ,KakkarVV,LupuC:Expression,localization,andactivityoftissuefactorpathwayinhibitorinnormalandatherosclerotichumanvessels.ArteriosclerThrombVascBiol2000,2...
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HumanCytomegalovirusInfectionofaSevere-BurnPatient:EvidenceforProductiveSelf-LimitedViralReplicationinBloodandLung
...ofsepticepisodesonthedynamicsofHCMVreplication(6,7,16).REFERENCESBale,J.F.,Jr.,G.P.Kealey,R.M.Massanari,andR.G.Strauss.1990.Theepidemiologyofcytomegalovirusinfectionamongpatientswithburns.Infect.ControlHosp.Epidemiol.11:17-22.Bale,J.F.,Jr.,G.P.Kealey,C.L.Ebelhack,C.E.Platz,andJ.A.Goeken.1992.Cytomeg...
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MumpsVirus-SpecificAntibodyTitersfromPre-VaccineEraSera:ComparisonofthePlaqueReductionNeutralizationAssayandEnzymeImmunoassays
...ningvaccine-inducedimmunity.J.Infect.Dis.169:77-82.Buynak,E.B.,J.E.Whitman,Jr.,R.R.Roehm,D.H.Morton,G.P.Lampson,andM.R.Hilleman.1967.Comparisonofneutralizationandhemagglutination-inhibitiontechniquesformeasuringmumpsantibody.Proc.Soc.Exp.Biol.Med.125:1068-1071.Christenson,B.,andM.Bottiger.1990.Metho...
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经桡动脉介入治疗导引导管的选择
...术。2.右冠脉的常规选择右冠脉的介入治疗中,常规选择JR3.5。如果冠脉开口异常,或者血管扭曲需要较好支撑力时,可以换用XBRCA或者Amplatz1(AL1)等。选择导管时,既要考虑支撑力和同轴性,还要考虑安全性,要小心操作避免...
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UncultivatedPhylotypesandNewlyNamedSpeciesAssociatedwithPrimaryandPersistentEndodonticInfections
...awithendodonticinfections.J.Endod.25:413-415.Baumgartner,J.C.,J.F.Siqueira,Jr.,T.Xia,andI.N.Ras.2004.Geographicaldifferencesinbacteriadetectedinendodonticinfectionsusingpolymerasechainreaction.J.Endod.30:141-144.Brinig,M.M.,P.W.Lepp,C.C.Ouverney,G.C.Armitage,andD.A.Relman.2003.Prevalenceofbacteriaof...
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EmergenceofaNephropathogenicAvianInfectiousBronchitisViruswithaNovelGenotypeinIndia
.../BrelatedavianinfectiousbronchitisvirusinIndia.Vet.Rec.144:299-300.Gelb,J.,Jr.,B.S.Ladman,M.Tamayo,M.Gonzalez,andV.Sivanandan.2001.NovelinfectiousbronchitisvirusS1genotypesinMexico1998-1999.AvianDis.45:1060-1063.Gelb,J.,Jr.,J.B.Wolff,andC.A.Moran.1991.Variantserotypesofinfectiousbronchitisvirusisola...
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ApoptosismodulatesprotectiveimmunitytothepathogenicfungusHistoplasmacapsulatum
...entofVeteransAffairsandbyNIHgrantsAI-34361andAI-42747.ReferencesDeepe,G.S.,Jr.2000.Histoplasmacapsulatum.InPrinciplesandpracticeofinfectiousdiseases.5thedition.G.L.Mandell,J.E.Bennett,andR.Dolin,editors.ChurchillLivingstone.Philadelphia,Pennsylvania,USA.2718–2732..Allendorfer,R.,Brunner,G.D.,andDe...
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Real-Time-PCRAssayforDiagnosisofEntamoebahistolyticaInfection
...tolytica.J.Clin.Pathol.47:236-239.Haque,R.,I.K.M.Ali,S.Akther,andW.A.Petri,Jr.1998.ComparisonofPCR,isoenzymeanalysis,andantigendetectionfordiagnosisofEntamoebahistolyticainfection.J.Clin.Microbiol.36:449-452.Haque,R.,A.S.Faruque,P.Hahn,D.M.Lyerly,andW.A.Petri,Jr.1997.EntamoebahistolyticaandEntamoeba...
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吉首地区病原菌的耐药调查
...0种包括:青霉素G(PCG),苯唑西林钠(OCS),美洛西林(MCN),氨苄西林(AMP),头孢唑啉(CFZ),红霉素(EM),四环素(TAC),氯林霉素(CDM),磺胺甲基异唑(SMZ),利福平(RFP),亚胺培南一西司他丁(IPC),万古霉...
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Lackofarelationbetweenvitaminandmineralantioxidantsandbonemineraldensity:resultsfromtheWomen‘sHealthInitiative
...ologyandBiostatistics,UniversityofCaliforniaatSanFrancisco,SanFrancisco,CA(MCN,JAS,andKLS);theGeneralInternalMedicineSection,SanFranciscoVAMedicalCenter,SanFrancisco,CA(JAS);andtheUniversityofBuffalo,Buffalo,NY(JWW)2Supportedbytraininggrantno.5T32AG000181-15fromtheNationalInstitutesofHealth.3Reprint...
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RelativeReductionofEndothelialNitric-OxideSynthaseExpressionandTranscriptioninAtherosclerosis-ProneRegionsoftheMouseAortaandinaninVitroMo
...Jongstra-Bilenforhelpfulcommentsandtechnicalassistance.【参考文献】HajraL,EvansAI,ChenM,HydukSJ,CollinsT,CybulskyMI:TheNF-Bsignaltransductionpathwayinaorticendothelialcellsisprimedforactivationinregionspredisposedtoatheroscleroticlesionformation.ProcNatlAcadSciUSA2000,97:9052-9057DaviesPF,ShiC...
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-GlutamylcysteineSynthetaseMediatesthec-Myc-DependentResponsetoAntineoplasticAgentsinMelanomaCells
...damage.CellCultureConditionsandTransfections.Allmelanomacelllines(M14,PLF2,JR1,JR8,SAN,CCH,FRM,andSbCl)wereobtainedfromthepatients‘biopsy.LPandLMcelllineswerederivedfromanodularprimarycutaneousmelanoma(LP)andasupraclavicularmetastaticlymphnode(LM)ofthesamepatient(Leonettietal.,1999).Cellsweremaint...
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RegulationofPlasmaHigh-DensityLipoproteinLevelsbytheABCA1TransporterandtheEmergingRoleofHigh-DensityLipoproteinintheTreatmentofCardiovasc
...DenisM,MartindaleD,FrohlichJ,MorganK,KoopB,PimstoneS,KasteleinJJP,GenestJJ,Jr,HaydenMR.MutationsinABC1inTangierdiseaseandfamilialhigh-densitylipoproteindeficiency.NatureGenet.1999;22:336–345.BodziochM,OrsoE,KluckenJ,LangmannT,BottcherA,DiederichW,DrobnikW,BarlageS,BuchlerC,Porsch-OzcurumezM,Kamini...
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InteractionStudiesofMultipleBindingSitesonM4MuscarinicAcetylcholineReceptors
...ts[acetylcholine,4-(m-chlorophenylcarbamoyloxy)-2-butynyltrimethylammonium(McN-A-343),orxanomeline]revealedlowdegreesofnegativecooperativitybetweenWIN62,577andeachagonist,whereasstrongernegativecooperativitywasobservedagainstatropine.Itisinterestingthatwhentheseexperimentswererepeatedusingtheprototy...
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急性心梗置入TaxusLiberte一例
...背抬高0.4mv诊断示:LAD中段次全闭塞右股动脉穿刺6F鞘管JL4JR4造影导管显示:三支病变(LAD中段次全闭塞.血栓,LCX中段80%狭窄,RCA弥漫病变)选择EBU3.75BMW导丝,2.0X15mmsprinter8atm10秒2次扩张后有50%的残余狭窄.后用TaxusLibter2.5X16mm覆盖病变11atm10...