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EndocrineRegulationofGender-DivergentMouseOrganicAnion-TransportingPolypeptide(Oatp)Expression
...tpexpressioninmice.Gonadectomizedmice,GH-releasinghormonereceptor-deficientlittle(lit/lit)mice,andhypophysectomizedmicewereusedwithreplacementofsexhormonesorGHinmaleorfemalesecretionpatterns.AndrogensincreasedOatp1a1mRNAinliverandkidney,whereasmale-patternGHadministrationincreasedOatp1a1mRNAinlivers...
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SOCS2negativelyregulatesgrowthhormoneactioninvitroandinvivo
...cisecapacity.ExogenousGHtreatmentimprovesthemetabolicprofile,enhancesthequalityoflife,increasesleanmusclemasswithareductioninbodyfat,reducestotalcholesterol,andincreaseslipolysis(4),butitcanalsoleadtothedeteriorationofglucosemetabolism(5).Overall,theuseofexogenousGHforthetreatmentofGHdeficiencyisext...
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EndothelialProgenitorCellsatWork
...heaccumulationofreactiveoxygenspecies(ROS)and,subsequently,ofoxidizedmetabolites.Eventually,invadingneutrophilsandmacrophagescontributeadditionaloxygenradicals(Figure).Thus,forthepurposeofrecreatingaperfusionnetworkinapostischemicenvironment,angiogenicprecursorcellsfirstofallhavetowithstandoxidative...
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晚期肝癌患者红细胞与淋巴细胞粘附肿瘤细胞能力的研究
...bin,GUOFeng. (TheDepartmentofImmunology,ChanghaiHospital,TheDecondMilitaryUniversity,Shanghai200433,P.R.China) 【Abstract】 Objective Tostudytheadheringofredbloodcellsandlymphocytestotumorcellsfromthepatientsofadvancedlivercancer.Methods Theimmune-adheringtestofredbloodcellsand...
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印染废水生物处理菌剂项目通过专家验收
...库,开发了组合工艺技术、活细胞固定化污水处理技术(LIT),并将Microtox技术应用在染料降解过程的监测中,为工程化推广应用提供了高效脱色菌株和工艺参数。作者:
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Dietaryglycemicload,overallglycemicindex,andseruminsulinconcentrationsinhealthyschoolchildren
...nconcentrationsinapopulationofhealthy8-y-oldchildren.Thetrialdesign,eligibilitycriteria,andsamplingmethodsweredescribedpreviously(3).Of164healthynewbornswhowererandomlyselectedfromalllivebirthsthatoccurredfromAugusttoDecember1991,dataattheageof8ywereavailablefor111children(105wereclassifiedasnormalw...
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NeuronalChemorepellentSlit2InhibitsVascularSmoothMuscleCellMigrationbySuppressingSmallGTPaseRac1Activation
...vascularResearchInstitute,MorehouseSchoolofMedicine,Atlanta,Ga.AbstractTheSlitsaresecretedproteinswithrolesinaxonalguidanceandleukocytemigration.OnbindingtoRoboreceptors,Slit2repelsdevelopingaxonsandinhibitsleukocytechemotaxis.Slit2iscleavedintoSlit2-N,aproteintightlybindingtocellmembranes,andSlit2-...
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外周动脉病(PAD)
...nsionHypercholesterolemiaAlcohol0.75123456RelativeRiskReducedIncreasedMortalityisveryhighinpatientswithseverePADRelative5-yearmortality1.CriquiMH.VascMed2001;6(suppl1):3–7.2.McKennaMetal.Atherosclerosis1991;87:119–28.3.RiesLAGetal.(eds).SEERCancerStatisticsReview,1973–1997.US:NationalCancerIns...
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高频超声对白内障的诊断价值
...thefeaturesof108cataractcases(216eyes),156lenscataractsandwerecomparedwithslitlamp.ResultsIntheinitialperiodofcataract,thesensitivitywaslowerthanthatofslitlamp.Thefalsenegativeratioofultrasonographywas17.86%,inthemiddleandlastperiodofcataractandinthetraumaticcataract,therelevantratioofultrason...
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高频超声对白内障的诊断价值
...thefeaturesof108cataractcases(216eyes),156lenscataractsandwerecomparedwithslitlamp.ResultsIntheinitialperiodofcataract,thesensitivitywaslowerthanthatofslitlamp.Thefalsenegativeratioofultrasonographywas17.86%,inthemiddleandlastperiodofcataractandinthetraumaticcataract,therelevantratioofultrason...
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EstablishmentofaFunctionallyActiveCollagen-BindingVascularEndothelialGrowthFactorFusionProteinInSitu
...ionofendothelialcells(ECs)andangiogenesis.1PreviousstudiessuggestthefeasibilityofVEGFtotreatarterialdiseasessuchasrestenosisandischemia.2-6Duringembryogenesis,VEGFisaninitialdeterminantofhemangioblastdifferentiationintoendothelialprogenitorcells(EPCs).7-10Recently,weisolatedEPCsfromperipheralbloodan...
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RegulationofEndothelialCellandEndothelialProgenitorCellSurvivalandVasculogenesisbyIntegrin-LinkedKinase
...(ECM),reattachmentontonewECM,andfinalincorporationintonewvasculature.TheabilityofECstoformcapillary-likestructuresisessentialforangiogenesisinvivo.However,inischemictissue,becauseofthedisruptionofthemicroenvironment,whichisnecessaryforsproutingandrecruitingofpre-existingECs,thesurvivalandincorporati...
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银杏叶提取物无助于预防痴呆请勿随意服用
...8:835-840.ContextSeveralover-the-countertreatmentsaremarketedashavingtheabilitytoimprovememory,attention,andrelatedcognitivefunctionsinaslittleas4weeks.Theseclaims,however,aregenerallynotsupportedbywell-controlledclinicalstudies.ObjectiveToevaluatewhetherginkgo,anover-the-counteragentmarketedasenhan...
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EndothelialE-SelectinPotentiatesNeovascularizationviaEndothelialProgenitorCell-Dependentand-IndependentMechanisms
...lyEPCbutalsothesolublefactortheysecretedorexpressedmayalsobeimportanttofacilitateneovasculogeneisis.14Toformproperlyassembledbloodvessels,EPCorchestratecomplexcell-celladhesiveinteractionsbycoordinatedactionsofadhesionmoleculesandtheirligandsexpressedonbothEPCandpreexistingendothelialcells.E-selecti...
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ConstitutiveExpressionofPeroxisomeProliferator-ActivatedReceptor-RegulatedGenesinDwarfMice
...omeofthesegeneproductswerealsoalteredinotherdwarfmousemodels,includingAmes,Little,andgrowthhormonereceptor-nullmice.TheconstitutiveincreasesinPPAR-regulatedgenesmaybepartlycausedbyincreasedexpressionofPPARmRNAandproteinasobservedintheliversofcontrolSnelldwarfmice.Theseresultsindicatethatsomeoftheben...
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普伐他汀在冠心病等危症患者的降脂效果及安全性观察
...tihypertensiveandLipid-LoweringtreatmenttopreventHeartAttackTrial(ALLHAT-LIT).JAMA,2002,288:2998-3007. 3SaiaF,deFeyterP,SerruysPW,etal.LescolInterventionPreventionStudy(LIPS)Investigators.Effectoffiuvastatinonlong-termoutcomeaftercoronaryrevascularizationwithstentimplantation....
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四、处方常用拉丁词缩写与中文对照表
...ovenosa静脉注射Lin.Inimentum擦剂Liq.Liquor,liquidus溶液,液体的Lit.Litrum升LotLotio洗剂Mist.Mistura合剂Ml.Millilitrum毫升Mg.Milligramma毫克Muc.Mucilago胶浆剂NNocte夜晚n.et.mNocteetmane在早晚Neb.Nebula喷雾剂o.d.Omnidie每日O.D.Oculusdexter右眼O.L.Oculuslaevus左眼O...
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裂隙灯显微镜下电解倒睫术
...键词倒睫电解裂隙灯显微镜 Applyelectrolysistrichiasisunderslit-lampmicroscope HuangDuru,HuangZhongning ThePeople’sHospitalofdongshandistrict,Guangzhou510080. 【Abstract】ObjectiveToimproveelectrolysistrichiasismethodstoincreaseinsuccessrateanddecreaseincomplicatio...
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AreCirculatingCD133+CellsBiomarkersofVascularDisease?
...atteman@uiowa.eduSinglecellbonemarrowtransplantationleavesnodoubtastotheabilityofbonemarrowcellstodifferentiateandintegrateintotheendothelium,thoughthephysiologicalsignificanceofthisremainscontroversial.Reportedratesofbonemarrowcellintegrationintotheendotheliumafterinjuryvarywidely,rangingfromalmost...
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Tetanization-inducedpelvic-to-pudendalreflexplasticityinanesthetizedrats
...nisthadnoeffectonthispotentiation.Bothintrathecalglutamate(0.1mM,2-5µlit)andNMDA(0.1mM,2-5µlit)inducedapotentiationofPPRsimilartothatoftetanization.Agonist-inducedpotentiationwasshorterthantetanization-inducedpotentiation.Thedurationofthecontractionwaveofintraurethralpressure,elicitedbyP...
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Absenceofghrelinprotectsagainstearly-onsetobesity
...importantroleforendogenousghrelininthemetabolicadaptationtonutrientavailability.SeetherelatedCommentarybeginningonpage3393IntroductionGhrelinisa28-aapeptideproducedpredominantlybythestomachandistheendogenousligandforthegrowthhormonesecretagoguereceptor(GHSR)(1).Inadditiontopotentlystimulatinggrowthh...
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EndothelialProgenitorCells:MoreThananInflammatoryResponse?
...CTTheformationofnewcapillaries(angiogenesis)maybeofclinicalimportanceinfacilitatingreperfusionandregenerationofhibernatingcardiactissueaftermyocardialinfarctionandinmicrovascularischemia.Evidenceisaccumulatingthataspartoftheresponsetohypoxia,bonemarrow-derivedcirculatingendothelialprogenitorcells(CE...
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InfectionbyChlamydophiliaaviuminanElderlyCoupleWorkinginaPetShop
...pathywasnotpresent.Laboratoryfindingsshowedawhitebloodcellcountof10.05x109/liter(neutrophils,90.8%;lymphocytes,5.4%).Cultureexaminationofsputuminducedby3%salinewasnegative.Bloodcultureexaminationswerelikewisenegative.Table1showsantibodytitersagainstMycoplasmapneumoniae,Chlamydophiliaavium,andChlamyd...
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CharacterizationofTwoTypesofEndothelialProgenitorCellsandTheirDifferentContributionstoNeovasculogenesis
...±SEM.IntergroupcomparisonswereperformedbypairedStudentttestorANOVA.ProbabilityvaluesofP0.05wereinterpretedtodenotestatisticalsignificance.ResultsTwoDifferentTypesofEPCTheinitiallyseededcellswereround(Figure1a).After3to5days,attachedcellsappearedandappearedtobeclusters(Figure1band1c).Theywereelongat...
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肥大细胞类胰蛋白酶在其相关疾病中作用的研究
...thsmallmoleculeinhibitorsprovidesnewinsightsintotheunusualfunctionalinstabilityandquaternarystructureoftheprotease[J].Biochemistry,2005,44(9):3580~3590. [2]LiT,HeS.InductionofIL-6releasefromhumanTcellsbyPAR-1andPAR-2agonists[J].ImmunolCellBiol,2006,84(5):461~466. [3]LiT...
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BoneMarrowStemCellsforMyocardialInfarctionEffectororMediator?
...alinjection.Indeed,anumberofclinicaltrialsnowsuggestnotonlysafetyandfeasibilityofstemcelltherapybutalsosignificantimprovementofleftventricularfunctioninpatientswithacutemyocardialinfarction.7–10 However,theabilityofBMCstotransdifferentiateintocardiacmyocyteshasrecentlybeenquestionedbyva...
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Piliprovepertinenttoenterococcalendocarditis
...edbytheemergenceofdrug-resistantstrains,whichcontributesignificantlytomortalityassociatedwithE.faecalisinfection.InthisissueoftheJCI,NallapareddyandcolleaguesreportthatE.faecalisproducespilionitssurfaceandthattheseproteinaceousfibersareusedforbacterialadherencetohosttissuesandfortheestablishmentofbi...
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Niche-DependentTranslineageCommitmentofEndothelialProgenitorCells,NotCellFusioninGeneral,IntoMyocardialLineageCells
...IntroductionSomaticstemandprogenitorcellshaverecentlydemonstratedtheflexibilityinlineagecommitmentfortissueregeneration.Althoughbonemarrowcellspresentedmultiplelineagepotential,hematopoieticstemcelldemonstratedtranslineagecommitmentintootherlineagecells,suchasvascularcell,1,2neuralcell,3,4hepaticcel...
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PathwayforDifferentiationofHumanEmbryonicStemCellstoVascularCellComponentsandTheirPotentialforVascularRegeneration
...ntiateintoothercelltypes,butmoredifferentiatedVE-cadherin+ECsmaylosethisability.Figure3.IsolationandexpansionofvasculareECs.A,Flow-cytometricanalysisofhumanEScell–derivedcellsonanOP9feederlayeronday10.B,NetworkformationofhumanEScell–derivedVE-cadherin+cells(eECs)after24-hourcultureonMatr...
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ReconstitutedHigh-DensityLipoproteinStimulatesDifferentiationofEndothelialProgenitorCellsandEnhancesIschemia-InducedAngiogenesis
...lyunderstood.AtheroprotectivefunctionsofHDLarethoughttobeattributedtotheabilityofHDLtouptakecellularcholesterolfromperipheralorgansandtomediatethetransportofexcesscholesteroltotheliver.InadditiontotheconventionalroleofHDL,recentstudiesrevealedthatHDLhasvariousfavorableeffectsonendothelialcells.2Angi...