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郎格罕细胞组织细胞增生症
...述】郎格罕细胞组织细胞增生症(Langenhanscellhistiocytosis,LCH),原称组织细胞增生症X,是一组原因未明的组织细胞增殖性疾患。传统分为三种临床类型,即莱特勒西韦综合征,(Litterer-Siwe病,简称L-S病),汉-薛-柯综合征,(Hand-S...
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11例眼眶朗格尔汉斯细胞组织细胞增多症的临床分析
...10(宁波)为了探讨眼眶朗格尔汉斯细胞组织细胞增多症(LCH)的临床表现、影像学特征、诊断方法及治疗原则。研究者对11例眼眶LCH患者的临床症状、眼部体征、影像学检查、治疗方法及随访情况等临床资料进行回顾性分析,其中...
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莱特勒-西韦病1例报告
...2讨论郎格罕细胞组织细胞增多症(langerhanscellhistocytoses,LCH)又称郎格罕细胞组织增生症X(histiocytosisX,HX),是一组少见、临床表现多样、多发于小儿的疾病,男多于女。以分化较好的异常组织细胞、淋巴细胞、嗜酸细胞和正常...
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Mortalin-BasedCytoplasmicSequestrationofpinaNonmammalianCancerModel
...ersdisplayingasimilarmortalin-basedphenotype.Treatmentofthesemodelswithnovelchemotherapeuticsmayhelprevealthemolecularmechanism(s)involvedininactivatingp53bythisformofcytoplasmicsequestration.--------------------------------------------------------------------------------Analyzingtheeffectsofcytotox...
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鬼臼乙叉甙治疗相关性急性早幼粒细胞白血病
...5例为意大利人)的原发肿瘤为郎格罕细胞组织细胞增生症(LCH),并且在这些病人的治疗方案中,除鬼臼乙叉甙、强地松和长春碱外,未用过其它化疗药物,故对LCH病人使用鬼臼乙叉甙时可能有较高的t-APL发生率。根据目前的文献,...
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从甜高梁生产生物燃料:发酵产氢和残余生物质厌氧消化
...产氢反应器的排出物是生产甲烷的理想基质,产出约为29LCH4/kg甜高梁。甜高梁榨取工艺残留物的厌氧消化,产出78LCH4/kg甜高梁。这个实验表明,生物氢生产能十分高效率地同随后的甲烷生产步骤结合,因而甜高梁能是一种理想的...
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肝脏郎格罕组织细胞增生症1例
...论郎格罕细胞组织细胞增生症(Langenhanscellhistio-cytosis,LCH),原称组织细胞增生症X,是一组原因未明的组织细胞增殖性疾患。传统分为三种临床类型,即莱特勒-西韦综合征(Litterer-Siwe病),汉—薛—柯综合征(Hand-Sch&uum...
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LaterecurrenceofLangerhanscellhistiocytosisintheorbit
...;Langerhanscell;orbit;tumourWereportararecaseofLangerhanscellhistiocytosis(LCH)ofboneinwhichrecurrenceoccurredintheorbit16yearsaftertheinitiallesion.CasereportAnotherwisehealthy23yearoldmanpresentedtotheeyecasualtydepartmentcomplainingofseverepainaroundhisleftlateralorbitalrimfor8days.Twoweeksprevio...
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矮身材儿童检查颅部MRI的临床意义
...本组有3例空蝶鞍患儿。朗罕组织细胞增生症(Langerhans,LCH)常累及下丘脑或垂体柄,往往合并全身其他部位的病变,也可以仅限于下丘脑或漏斗,最后可弥漫分布于脑内,鞍区LCH多为汉-许-克(Hand-Schüller-Christian)病。临床...
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第二节 甘油三酯测定
...3h以上闭封一周R3皂化剂5%KOH5g+H2O→100ml R4醋酸溶液2mol/LCH3COOH11.5ml+H2O→100ml R5过碘酸钠0.05mol/LNaIO41.07g+H2O→100ml R6氧化剂 R41体积+R51体积 一周R7醋酸铵液 CH3COONH215.4g+H2O→100ml R8显色剂CH3COCH2COCH30.75ml+R-140ml+R-7100ml+R-4...
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Presenceofosteoclast-likemultinucleatedgiantcellsintheboneandnonostoticlesionsofLangerhanscellhistiocytosis
...logy,UniversityHospitalGhent,B-9000Gent,BelgiumLangerhanscellhistiocytosis(LCH)isadiseasethatcaninvolveoneormultipleorgansystemscharacterizedbyanaccumulationofCD1a+Langerhans-likecellsaswellasseveralothermyeloidcelltypes.Thepreciseoriginandroleofoneofthesepopulations,themultinucleatedgiantcell(MGC),...
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Afeasibilitystudyquantifyinginvivohuman-tocopherolmetabolism
...ranatantsolution.Isolatedlipoproteinfractionswereextractedbyadding200µLCH2Cl2containing0.01%BHTtoeachfractionstoredinanEppendorftube.Thesamplewasmixedbyvortexfor1minandcentrifugedat5000xgfor5minat23°C(FisherScientificAccuSpinMicro,NJ),andtheorganiclayerwastransferredtoanewEppendorftube.The...
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心肌梗死溶栓后出血的监护
...而,当临床应用纤维蛋白选择性高的t-PA行溶栓治疗时,LCH发生率反而高于选择性较低的链激酶(SK)以及尿激酶(UK),故纤溶亢进难以全部解释出血的原因。 2.2肝素作用 肝素在抑制凝血酶活性后可使纤维蛋白原转变为...
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SerumtransferrinreceptorconcentrationindicatesincreasederythropoiesisinKenyanchildrenwithasymptomaticmalaria
...9;C-reactiveproteinfalciparummalariahelminthiasispreschoolchildrenKenyacommunitysurveyINTRODUCTIONIrondeficiencyandmalariaarelikelycausesofanemiainAfricanchildren(14),butlittleisknownaboutthepathogenicmechanismsinvolved.Malarialeadstohemolysis,impairederythropoies...
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GlucocorticoidReceptorNuclearTranslocationinAirwayCellsafterInhaledCombinationTherapy
...alizedGRtothecytoplasmornucleusalone.Anexperiencedobserverblindtotheclinicalcharacteristicsofthesubjectperformedcellcountingon300cellswithineachcellpopulation.ConfocalLaserImmunofluorescenceStainingSeparatecytospinpreparationswereusedtodetailthemagnitudeofdifferenceinGRsubcellularlocalizationusingco...
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OverexpressionofHyaluronanintheTunicaMediaPromotestheDevelopmentofAtherosclerosis
...nofHAinthetunicamediaoflargeandsmallvessels.Weinvestigatedtheultrastructuralchangesinthearterialwall,thestiffnessandstrengthofaorticrings,andtheinfluenceonthedevelopmentofatherosclerosisinApoE-deficientmice.MaterialsandMethodsProductionofhHAS2TransgenicMiceArestrictionfragmentcontainingthemouseSMC-a...
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HypoxiaDisruptstheBarrierFunctionofNeuralBloodVesselsthroughChangesintheExpressionofClaudin-inEndothelialCells
...aling,20µmol/LsiRNAin30mmol/LHepes-KOHbuffer,pH7.4,containing100mmol/LCH3COOK,and2mmol/L(CH3COO)2Mgwasincubatedat90??Cfor1minuteandsubsequentlyat37??Cfor1hour.Then,usingtheNucleofectorkit(Amaxa,Gaithersburg,MD),2µgofsiRNAwastransfectedinto1x106bEND.3cellssuspendedin100µlofNucleofec...
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GlycemicindexinthedietofEuropeanoutpatientswithtype1diabetes:relationstoglycatedhemoglobinandserumlipids
...tsfromnorthern,western,andeasternEuropeancenters.Oftheserumlipids,onlytheHDLcholesterolinpatientsfromtheseEuropeancenterswasindependentlyrelatedtotheGI(P=0.002).InsouthernEuropeancenters,theconsumptionofpasta,temperate-climatefruit,whitebread,andpotatoeslargelydeterminedthepatients‘dietaryGI,where...
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CharacterizationofNovelAryl-Ether,Biaryl,andFluoreneAsparticAcidandDiaminopropionicAcidAnalogsasPotentInhibitorsoftheHigh-AffinityGlutamate
...o,California(R.P.,J.W.,A.F.)AbstractInthisstudy,wedescribethepharmacologicalcharacterizationofnovelaryl-ether,biaryl,andfluoreneasparticacidanddiaminopropionicacidanalogsaspotentinhibitorsofEAAT2,thepredominantglutamatetransporterinforebrainregions.Therankorderofpotencydeterminedfortheinhibitionofhu...
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ThrombinRegulatesSolublefms-LikeTyrosineKinase-(sFlt-)ExpressioninFirstTrimesterDecidua
...negative.Thesecellsdisplaycharacteristicdecidualization-relatedmorphologicalchangesandincreasedsecretionoftissuefactor,plasminogenactivatorinhibitor-1,andprolactininresponsetoprogestin.28,29TermDecidualCellCultures95%oftheisolateddecidualcellsasviable.Theculturesweregrowntoconfluenceinastandard95%ai...
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Hydrogenperoxideandepidermalgrowthfactoractivatephosphatidylinositol3-kinaseandincreasesodiumtransportinA6cellmonolayers
...ewascollectedandevaporatedunderaflowofnitrogen.Sampleswereredissolvedin80μlCH3OH/CHCl3(1:1,vol/vol)andspottedundernitrogenonanoxalate-precoatedTLCplate.Aftermigration(eluant:CH3COCH3,CH3OH,CH3COOH,H2O,CHCl3,30:26:24:14:80,vol/vol/vol/vol/vol),radioactivespotswerevisualizedandthephosphatidylinositol...
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TheClassSemaphorinSEMAAIsInducedbyInterferon-andDefinesanActivationStatusofLangerhansCellsObservedinPathologicalSituations
...ronglyexpressedonskinandboneLCsandonLCsindraininglymphnodesfrompatientswithLChistiocytosisordermatopathiclymphadenitis,respectively,representingtwoinflammatoryconditionsinwhichLCsdisplayanimmatureDC-LAMPlow,CD83low,andCCR7+phenotype.SEMA6AexpressionwaslowinrestingLCsgeneratedinvitroandwasenhancedbyi...
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PulmonaryDendriticCells
...ssibleroleofDCsinthedevelopmentofemphysemaitself.AnindirectindicationisthatLChistiocytosis(LCH)ofthelung,whichisalsoassociatedwithsmokingandinvolvesapathologicaccumulationofLCs,isaccompaniedbydestructivelesionsinthealveolarzones.Onacellularandmolecularlevel,ithasbeenshownthat,duringthedifferentiatio...