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Moderateddiscussion
PeterFürst,moderatorDrFürst:Iwouldliketoemphasizethat400companiesareinvolvedinmarketingfunctionalfoods.Theyrepresent6%ofthetotalfoodmarket,or$7billion.Sofunctionalfoodsareofenormouscommercialvalue.Arewesatisfiedwiththeexistingdefinitionforfunctionalfood?Shouldwetrytodefinefunctionalfoodsat...
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过氧化物酶体增殖剂激活受体的研究进展和应用前景
...-α/γ双重激动剂 在体外活性测试中,化合物DRF2725显示出较高的PPAR-α/γ双重激动活性。在临床研究中,DRF2725也表现出较好的降血糖、血脂作用。DRF2725进入了Ⅲ期临床研究,然而,由于在动物试验中,发现...
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Moderateddiscussion
...polyphenols,andgenisteinandopenthemeetingfordiscussion.Beforewebegin,DrFürstwouldliketomakeacomment.DrFürst:Iwouldliketoraisethequestionofbioavailability,whichisaproblemwhendealingwithphytochemicals.Anovelwaytostudybioavailabilityistheuseofanisolatedratsmallintestine[PlauthM,KremerI,...
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二维和三维四极杆离子阱蛋白质组数据质量的定量比较
...TQ中离子阱由具有双曲线轮廓的四极杆构成,由其产生的2Drf电场以及不连续DC电压将用于将离子容纳在阱中央的轴向方向。LTQ中在居中的两个杆上打开一个小口方便离子的射入和被两个检测器检测(LCQ是在端电极上由离子射入口...
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Growth,bonemass,andvitaminDstatusofChineseadolescentgirls3yafterwithdrawalofmilksupplementation
...g,LengHuatFoo,AngelikaTrube,GuanshengMa,XiaoqiHu,XueqinDu,ChrisTCowell,DavidRFraserandHeatherGreenfield1FromtheFacultyofVeterinaryScience,UniversityofSydney,Sydney,Australia(KZ,QZ,LHF,AT,XD,DRF,andHG);theInstituteforNutritionandFoodSafety,ChineseCenterforDiseaseControlandPrevention,Beijing,China(QZ,...
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冠状动脉造影正常的急性心肌梗死12例临床分析
...血管活性物质对冠脉舒缩产生影响。如内皮舒缓因子(EˉDRF)的缺乏或不足可引起冠脉痉挛。现已证明,乙酰胆碱能诱发内皮功能受损的冠脉痉挛:而正常冠脉乙酰胆碱可刺激完好的内皮细胞释放EDRF,使之不会发生痉挛[5]。故...
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PPAR激动剂类抗糖尿病药研发喜忧参半
...诺德公司在临床前研究中发现,PPAR激动剂Ragaglitazar(NN622/DRF2725)可使实验鼠的尿路膀胱肿瘤发生率增高,因而暂停了其Ⅲ期临床研究。2003年,默克公司和日本杏林制药公司在动物长期毒性实验中也发现,在研的PPAR-α、γ激动剂MK...
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《免疫学杂志》1999年(第15卷)目录索引
...格局的作用 范祖森马宝骊(220) 中国拉祜族人HLA-DRF的快速DNA分型 洪坤学褚嘉佑卫灿东等(223) 人PBMC中IL-18基因的克隆及在E.coli中的高效表达与纯化 杜勇汪涛杜桂鑫等(226) 抗HbsAg抗体Fab段在大肠杆菌中的高...
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山莨菪碱对乳癌术后皮瓣的保护作用
...血管平滑肌两种途径实现的,并且与PGI2(前列环素)、E-DRF(内皮源性舒张因子)和KATP(ATP敏感性钾通道)开放均有关[4]。所有患者应用山莨菪碱后均出现颜面颈胸等处皮肤潮红,正是山莨菪碱扩张微血管作用的有力证据。...
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QualityofHospitalandOutpatientCareAfterStrokeorTransientIschemicAttack
...atieZuider,Rotterdam,DrR.Saxena,DrE.Thomeer;StFranciscusGasthuis,Rotterdam,DrF.H.Vermeij;TweeStedenZiekenhuis,Tilburg,DrB.P.W.Jansen;StElisabethZiekenhuis,Tilburg,DrP.L.M.deKort;AcademischZiekenhuisMaastricht,Maastricht,DrR.J.vanOostenbrugge.Datacollectionofficers:M.Beijerink,H.Broers,A.vandenDool,H...
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Diaphanous1and2RegulateSmoothMuscleCellDifferentiationbyActivatingtheMyocardin-RelatedTranscriptionFactors
...ndmDia2).22-24Theseproteinsbelongtothesubfamilyofdiaphanous-relatedformins(DRFs)thatalsoincludesDia3andFHOD1.PreviousstudieshavedemonstratedthattheDRFsactaspotentactinandmicrotubulepolymerizingfactorsthatregulateanumberofprocessesincludingcellmigrationanddivision(seeHiggs25andWallaretal26forreviews)...
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PerivascularAdiposeTissueandMesentericVascularFunctioninSpontaneouslyHypertensiveRats
...edvascularresistanceobservedinSHR.【关键词】perivascularadiposetissueADRFmesentericarteriesSHRIntroductionEarlierstudiesuncoveredaparacrineroleforadiposetissueintheregulationofvascularfunction.SoltisandCassis1demonstratedthatperivascularfatsignificantlyattenuatedvascularresponsivenessofaorticri...
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FishoilandantioxidantsalterthecompositionandfunctionofcirculatingmononuclearcellsinCrohndisease
TimothyMTrebble,NigelKArden,StephenAWootton,PhilipCCalder,MarkAMullee,DavidRFineandMikeAStroud1FromtheInstituteofHumanNutrition,SchoolofMedicine(TMT,SAW,PCC,andMAS),theMRCEnvironmentalEpidemiologyUnit(NKA),theMedicalStatistics/SouthamptonStatisticalSciencesResearchInstitute(MAM),andtheDivisionofInfe...
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EtiologyofanemiainpregnancyinsouthMalawi
...gestthatironsupplementationalonewillnotprovidetheoptimalsolution.DISCUSSIONDrFleming:WhydoyouthinkthesepatientshavevitaminB-12deficiency?DrvandenBroek:Itisdifficulttosay.ApaperfromZimbabwebySavage[SavageD,GangaidzoI,LindenbaumJ,etal.VitaminB12deficiencyistheprimarycauseofmegaloblasticanaemiainZimbab...
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ErtiprotafibImprovesGlycemicControlandLowersLipidsviaMultipleMechanisms
...(2001)(-)3-[4-[2-(phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoicacid[(-)DRF2725]:adualPPARagonistwithpotentantihyperglycemicandlipidmodulatingactivity.JMedChem44:2675-2678.McGovernSL,CaselliE,GrigorieffN,andShoichetBK(2002)Acommonmechanismunderlyingpromiscuousinhibitorsfromvirtualandhigh-throughp...