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ASelectivePositiveAllostericModulatorofMetabotropicGlutamateReceptorSubtype2BlocksaHallucinogenicDrugModelofPsychosis
...llucinogenic5-HT2A/2Creceptoragonist(-)2,5-dimethoxy-4-bromoamphetamine[(-)DOB].BINAattenuatesserotonin-inducedincreasesinspontaneousexcitatorypostsynapticcurrentsinthemPFC,mimickingtheeffectofthemGlu2/3receptoragonist(2S,2‘R,3‘R)-2-(2‘,3‘-dicarboxycyclopropyl)glycine(DCG-IV).Inaddition,BINA...
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胃体胃炎患者13C尿素呼气试验易呈假阴性
...胃内pH值。结果显示,66例Hp感染患者的平均丰度基数差值(DOB)为15.5,平均胃内pH值为4.9,与33例Hp阴性者(平均pH值为2.5)相比差异显著(P=0.001)。其中21例(31.8%)13C-UBT结果呈假阴性,敏感性为68.2%,平均DOB值为1.8。66例Hp感染患者中,16例(24.2%)为...
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汉坦病毒Z10株M片段全基因序列分析
...析表明,Z10株与HTN型核苷酸同源性为83.6%~87.4%,与SEO,DOB和Thai型为69.5%~70.8%,而与PUU和HPS各型病毒同源性仅为57.6%~59.9%。氨基酸同源分析Z10株与HTN型同源性高达94.2%~96.0%,与SEO,DOB和Thai型为73.3%~76.6%,而与PUU和HPS各型病毒...
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多巴酚丁胺负荷超声心动图对左室心尖部血栓与存活心肌的研究
...巴酚丁胺负荷超声心动图左室血栓心肌存活 Studyonthedobutaminestressechocardiographictestforleftventricularapicalthrombusandmyocardialviability YangXingyi,KangChunsong,WenJijun,etal. FenyangCollegeofShanxiMedicalUniversity,Shanxi032200. 【Abstract】Objec...
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Gene-dietinteractionsinobesity
...ncesuggeststhatquantitativetraitlociidentifiedfromanimalmodelsofdiet-inducedobesitycouldinfluencebodyfatinhumans.Despitethelimitednumberofstudies,theevidenceongene-dietinteractionsinobesityisconvincing.Moreresearchisneededtoidentifythegenesresponsiblefortheseinteractioneffects,andtheuseofanimalmodel...
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云南省啮齿动物中汉坦病毒自然感染状况调查
...[4,5]。比如,新近有研究者从爱沙尼亚黑线姬鼠分离出DOB型汉坦病毒(Saa株),而这种病毒与黄喉姬鼠来源的DOB型病毒无论是病毒核苷酸序列上,还是从中和试验上均明显不同,这提示黄喉姬鼠型毒株可能发生了宿主转换,传...
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肾综合征出血热流行病学研究进展
...(Seoul,SEO)、普马拉(Puumala,PUU)和多不拉伐一贝尔格莱德(Dobrova-Belgrade,DOB)病毒,它们的分布区在不断扩大。HTN主要分布在亚洲和欧洲;SEO分布最广,包括亚洲[7,8]、欧洲[9]、非洲[10]、美洲[11]等呈全球性分布:PUU分布...
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浙大生科大熊猫基因组研究成果登PloSOne
...3DQB,1DYB,1DPA和2DPB),4个非经典的MHCⅡ型基因(1DOA,1DOB,1DMA和1DMB)。其中,DYB与其他宿主相比较(小鼠、人、狗、牛)具有特异性,DYB是反刍动物特有的一个基因。研究小组绘制了基因进化树,对大熊猫的MHCⅡ型基因进行遗...
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RapidMultiplexAssayforSerotypingPneumococciwithMonoclonalandPolyclonalAntibodies
...onoclonalantibodieswereclonedtwicebylimitingdilution.Ahuman-mousehybridoma,Dob9,wasproducedbyhybridizingperipheralbloodlymphocytesfromapersonimmunizedwitha23-valentPSvaccine,asdescribedpreviously(23).PreparationoflatexbeadscoatedwithdifferentpneumococcalPSserotypes.Fifteendifferenttypesoflatexbeadsw...
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阿立哌唑治疗首发精神分裂症患者认知功能障碍的疗效比较
...ermmemory,shorttermmemory,immediatememory,memoryqutientofpatientsweredamagedobiously.Patientsgroupwaslowerthanthenormalgroup(P<005).After12weekstreatment,thetotalscoresandsubscalescoresofPANSSintwogroupsweredecreasedsignificantly.Thedecreasedratehadnosignificantdifferencesbetweenthetwogroups,w...
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丙型肝炎病毒致病机理研究的新进展
...,在持续感染人群中DRB1*03O1、DRB1*07O1、DEB1*1501、DRB4*0101、DOB1*02、DRB1*03O1、DQ,~I*05O1、DQI~I*0201的频率较HCV清除人群明显升高。3.2与丙型肝炎临床症状有关的人类基因研究发现DR13等位基因在病情较轻的丙肝患者比在病情较重丙肝患...
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关于公布麻醉药品和精神药品品种目录的通知
...1.布苯丙胺 Brolamfetamine(DOB) 2.卡西酮 Cathinone 3.二乙基色胺 DET 4.二甲氧基安非他明 2,5-dimethoxyamfeta...
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IABP在冠状动脉旁路移植术后低心排中的应用
...P:平均动脉压,PWCP:肺毛压,CVP:中心静脉压,Dop:多巴胺,Dob:多巴酚丁胺,Ad:肾上腺素3讨论术后出现低心排是一种严重的并发症,其发生率约为2%~10%,大部分病人(60%~80%)应用IABP即可恢复,仅有很少一部分(0.2%~1%)需要进...
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第五节 HLA的临床应用
...来发现某些疾病与DQ、DP等位基因相关,如:IDDM与DQA1*0301/DOB1*0302;发作性睡眠与DQA*0102/DQB1*0602;Hodgkin病与DPB1*0301(欧洲白人)、DPB1*0401(明显降低,黄种人)。表6-17不同小鼠品系对Gross病毒致白血病的易感性品 系H-2单体型...
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二、人HLA基因图及其遗传特征
...;DQB1编码DQβ链;DQA2、B2尚末得知其表达;DQB3为伪基因。DOB编码DOβ链DMA编码DMα链;DMB编码DMβ链。DNA编码DNα链、DPA1编码DPα链;DPB1编码DPβ链;DPA2和DPB2为伪基因。此外与肽运转至内质网有关的基因TAP1(transporterofantigenpeptides)、...
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HLAⅡ类基因PCR-SSP分型技术在骨髓移植配型中的应用
...15DQB1*04,DQB1*06192,81DQ4,DQ6donor10DRB1*04,DRB1*07,DRB4269,233.222DR4,DR7DOB1*04,DOB10201192,214DQ4,DQ225mmolMgCl2,1.5μl,2mm4×dNTPs2.5μl,模板DNA50ng,TaqDNA聚合酶1U(美国Pro-mega公司)。PCR扩增参数为:94℃预变性2min进入PCR循环:94℃40s,64℃40s,72℃40s,35...
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关于印发《麻醉药品和精神药品运输管理办法》的通知
...胺 Brolamfetamine(DOB)2.卡西酮 Cathinone3.二乙基色胺 DET4.二甲氧基安非他明 2,5-...
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HelicobacterPyloriInfectionCausesPersistentPlateletActivationInVivoThroughEnhancedLipidPeroxidation
...Scientific)TheUBTwasconsideredpositivewhenthedifferencewithbaselineat30‘(DOB30;ie,thedifferencebetween-valueat30‘and-valueatbaseline)was5%.ThisnoninvasivetestisasaccurateinpredictingHpyloristatusasinvasivetestsandistherecommendedtestfordiagnosisofHpyloriinfection.21Urinary8-iso-PGF2and11-dehydro...
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MolecularInteractionofSerotonin5-HT2AReceptorResiduesPhe339(6.51)andPhe340(6.52)withSuperpotentN-BenzylPhenethylamineAgonists
...T2Aagonistbinding(Wangetal.,1993;Kristiansenetal.,2000;Shapiroetal.,2000)andobservedpreviouslyinourwork(Parrishetal.,2005).Inthepresentwork,apotential-interactionwasidentifiedbetweenPhe339(6.51)andthenovelN-benzylmoietyoftheligand.MutationofthecognateresidueinavarietyofotherGPCRshasindicatedthatresi...
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-DependentToll-LikeReceptorExpressionandResponsivenessinPreadipocytesandAdipocytes
...imulationofpreadipocyteswithpoly(I:C)(25µmol/L)inducedsolelyindb/dbandob/obcellsasignificantincreaseinIL-6synthesis,whereas3T3L1aswellasWTcellswereunresponsive.TLR4stimulationviaLPS(1µg/ml)inducedthehighestproductionofIL-6inallpreadipocytecelllines.Additionaldose-responsestudiesrevealeda...