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肿瘤标志物CA19-9、CEA、CA125、CA50联合测定对胰腺癌的诊断价值
【摘要】目的研究与胰腺癌相关的血清糖类抗原19-9(CA19-9)、癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原50(CA50)4种肿瘤标志物在胰腺癌诊断中的价值。方法采用北京科美东雅微孔板光子计数分析仪和北京科美东雅生物...
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血清和胸腔积液CEA、CA50对肺癌的诊断价值
...要】目的探讨血清和胸腔积液癌胚抗原(CEA)、糖类抗原CA50(CA50)在肺癌患者诊断中的价值。方法采用放射免疫分析法(RIA)和免疫放射分析法(IRMA)对82例肺癌患者进行血清和胸腔积液CEA、CA50检测,并进行相关分析。结果肺...
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肿瘤标记物联合检测在非小细胞肺癌化疗中的意义
【摘要】目的探讨联合检测肿瘤标记物CEA、CA125、CA199、CA50对于非小细胞肺癌化疗的意义。方法对60例非小细胞肺癌病人行4个疗程化疗,化疗方案为NP、TP或GP,监测第1次化疗前和第3次化疗前肿瘤标记物CEA、CA125、CA199、CA50水...
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血清中CA50、CEA含量联合检测对诊断肺癌的临床价值
【摘要】目的探讨患者血清中糖链抗原50(CA50)、癌胚抗原(CEA)含量联合检测对肺癌、肺结核的诊断和鉴别诊断的临床价值。方法用放射免疫分析法和免疫放射分析法检测了112例肺癌和200例肺结核患者血清中CA50、CEA的含量,...
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Effectoftyrosinekinaseblockadeonnorepinephrine-inducedcytosoliccalciumresponseinratafferentarterioles
...rosinephosphorylationinnorepinephrine(NE)-inducedchangesinintracellularfreecalciumconcentration([Ca2+]i)inratafferentarterioles.[Ca2+]iwasmeasuredinmicrodissectedarteriolesusingratiometricphotometryoffura2fluorescence.Thecontrol[Ca2+]iresponsetoNE(1µM)consistedofarapidinitialpeakfollowedbyapla...
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肿瘤标志物在原发性肝细胞癌诊断中的价值
...研究对象,提取血样经放射免疫分析法测定血清AFP、SF、CA199、CA125、C50、CA153值;结果在原发性肝细胞癌患者中,阳性检出率大小顺序为AFP、SF、CA199、CA125、C50、CA153;在AFP检测阴性的患者中,阳性检出率大小顺序为SF、CA125、CA199、...
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血清肿瘤标志在大肠癌诊断中的临床意义
...者,通过联合检测:癌胚抗原(CEA)、肿瘤相关性抗原(CA50)血清水平,以探讨两项肿瘤标记物的诊断价值。报告如下。1资料与方法1.1研究对象(1)实验组:选自本院2001年6月~2002年12月住院患者286例(男196例,女90例,平均59.3...
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四种肿瘤标志物检测在原发性肝癌诊断中价值
...目的建立一种检测甲胎球蛋白(AFP),血清糖类抗原50(CA-50),癌胚抗原(CEA),血清铁蛋白(SF)并用于诊断原发性肝癌的实验诊断方法。方法用酶免及放免法分别检测200名正常人,65例慢性乙肝患者,85例肝癌患者的AFP,CA-50...
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腹水糖抗原19-9及癌胚抗原对良恶性腹水鉴别诊断的价值
...新途径。本文对100例不同病因引起的腹水病人,进行腹水CA19-9及CEA联合检测,以探讨其对良、恶性腹水鉴别诊断的价值。1资料与方法1.1一般资料病人均系我院住院患者,按通用标准诊断,由专人核实,常规抽取腹水。100例腹水...
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DynamicsofCa2+-DependentCl-ChannelModulationbyNiflumicAcidinRabbitCoronaryArterialMyocytes
...treeal(J.L.)ResearchCentre,MontreealHeartInstitute(J.L.),Montreeal,Queebec,CanadaDepartmentofBasicMedicalSciences,PharmacologyClinicalPharmacology,St.George‘sHospitalMedicalSchool,London,UnitedKingdom(I.A.G.)DepartmentofPharmacology,CentreofBiomedicalResearchExcellence,UniversityofNevadaSchoolofMe...
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RegulationofSTIM1,store-operatedCa2+influx,andnitricoxidegenerationbyretinoicacidinratmesangialcells
【摘要】Ithasbeenshownthatstore-operatedCa2+influx(SOC)playscriticalrolesintheactivationofendothelialnitricoxide(NO)synthase(eNOS)andgenerationofNOinendothelialcells.Recentstudiesindicatestromalinteractionmolecule1(STIM1)isthemoleculeresponsibleforSOCactivationfollowingCa2+depletionintheER.Retin...
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CA4P(Compretastatin)抗肿瘤作用的实验研究
【摘要】目的观察国内合成的抗肿瘤化合物CA4P对体外培养的人癌细胞和荷瘤动物的抗肿瘤作用,为抗癌新药的研究和开发提供实验依据。方法体外实验采用MTT法测定CA4P对培养的人癌细胞的半数生长抑制浓度(IC50);体内实验观...
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银杏达莫辅助治疗脑梗死的疗效观察
...细胞酸中毒和磷脂代谢障碍等进行联合治疗。正常状态下Ca2+在调节细胞功能方面具有“第二信使的作用,它介导细胞对外来的刺激做出收缩、释放神经介质、激活酶类等反应。病理状态下,细胞内外Ca2+的稳态失调是导致缺血...
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依托咪酯、丙泊酚和硫喷妥钠对大鼠心肌细胞质膜Ca2+-ATPase活性的影响
...同浓度依托咪酯、丙泊酚和硫喷妥钠对大鼠心肌细胞质膜Ca2+-ATPase活性的影响,探讨几种药物心肌抑制作用的可能机制。方法参照文献制备大鼠心肌细胞质膜,采用分光光度法观察不同浓度依托咪酯、丙泊酚和硫喷妥钠对质膜Ca2+...
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多肿瘤标志物蛋白芯片系统(C12)对胃癌诊断的临床价值
...抗原(CEA),神经原特异性烯醇化酶(NSE),癌抗原125(CA125),癌抗原153(CA153),糖链抗原242(CA242),糖链抗原19-9(CA19-9),前列腺特异性抗原(PSA),游离前列腺特异性抗原(F-PSA),铁蛋白(FER),β-人绒毛膜促性腺激...
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胃肠舒对大鼠胃肠平滑肌细胞钙离子浓度的影响
...】目的通过测定体外培养的SD大鼠胃肠平滑肌细胞内游离Ca2+浓度,观察胃肠舒对SD大鼠胃肠平滑肌细胞内游离Ca2+浓度的影响,探讨胃肠舒促胃肠动力的作用机制。方法离体培养SD大鼠胃肠平滑肌细胞,应用特异性Ca2+荧光探针Fura-2...
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肺癌患者血清CEA、CA125和CA19-9测定的临床意义
肺癌患者血清CEA、CA125和CA19-9测定的临床意义(pdf) [摘要]目的评价血清癌胚抗原(CEA)、糖类抗原25(CA125)和糖类抗原19-9(CA19-9)水平对肺癌诊断和病情评估的临床价值。方法用化学发光法检测血清CEA、CA125和CA19-9在正常组、良性...
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EffectsofchloridechannelblockersonratrenalvascularresponsestoangiotensinIIandnorepinephrine
【摘要】TheaimofthepresentstudywastoinvestigatetheroleofCa2+-activatedCl-channelsintherenalvasoconstrictionelicitedbyangiotensinII(ANGII)andnorepinephrine(NE).Renalbloodflow(RBF)wasmeasuredinvivousingelectromagneticflowmetry.Ratiometricphotometryoffura2fluorescencewasusedtoestimateintracellularf...
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AdrenomedullinStimulatesNitricOxideProductionfromPrimaryRatHypothalamicNeurons:RolesofCalciumandPhosphatases
...ocharacterizeADM-inducedNOproductionandtostudytheunderlyingmechanisms.UsingCalciumOrange/4-amino-5-methylamino-2‘,7‘-difluorofluoresceinfluorescencelivecellimaging,wefoundthatADM(1or10nM,5min)significantlyelevated[Ca2+]iandNOproductioninaconcentration-dependentmanner.Ca2+andNOresponsesinducedby1...
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血清CA242对消化道恶性肿瘤诊断的临床评价
【摘要】目的研究血清肿瘤标志物CA242对消化道恶性肿瘤诊断的临床价值。方法采用免疫放射分析法(IRˉMA)对胰腺癌、结直肠癌、胃癌、食道癌及非肿瘤对照组患者血清CA242含量进行测定。结果(1)血清CA242阳性率分别为胰腺...
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Calciumwaveoftubuloglomerularfeedback
...oglomerularfeedback(TGF)mechanismthatcontrolstheglomerularfiltrationrate.BecausethecellsoftheJGAexpressanumberofcalcium-coupledpurinergicreceptors,thesestudiestestedthehypothesisthatTGFactivationtriggersacalciumwavethatspreadsfromtheMDtowarddistantcellsoftheJGAandglomerulus.Ratiometriccalciumimaging...
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第二节 常见的肿瘤标志物及其应用评价
...作为一种较为常见的肿瘤标志物。 (一)癌胚抗原(carcinoembryonicantigen,CEA) 癌胚抗原是1965年Gold和Freedman首先从胎儿及结肠癌组织中发现的,CEA是一种分子量为22ku的多糖蛋白复合物,45%为蛋白质。CEA的编码基因位于19...
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CA125标志物与卵巢癌
...抗原越来越多,但敏感性和特异性均不够理想。近年来,CA125在卵巢癌的诊断、疗效监测和免疫治疗方面显示出可喜的应用前景。本文介绍了这方面的一些进展。 卵巢癌在女性生殖器癌中的发生率占第三位,但其病死率却占...
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ExtracellularATP-inducedcalciumsignalinginmIMCD-3cellsrequiresbothP2XandP2Ypurinoceptors
【摘要】KidneytubulesaretargetsfortheactivationoflocallyreleasednucleotidesthroughmultipleP2receptortypes.ActivationoftheseP2receptorsmodulatescellularCa2+signalinganddownstreamcellularfunction.ThepurposeofthisstudywastodeterminewhetherP2receptorswerepresentinmIMCD-3cells,amouseinnermedullarycol...
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尖锐湿疣组织HPV感染基因芯片分型检测研究
【摘要】目的了解尖锐湿疣(CA)组织中感染HPV病毒亚型分布,CA治疗后原皮损部位HPV的携带情况及性病门诊HPV隐性感染的发生率。方法利用HPV基因芯片对1625例性病门诊就诊者进行23种HPV亚型检测。结果693例CA患者皮损组织HPV阳性率9...
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Caveolin-1RegulatesStore-OperatedCa2+InfluxbyBindingofItsScaffoldingDomaintoTransientReceptorPotentialChannel-1inEndothelialCells
【关键词】Caveolin-1associatesCaveolin-1associateswithstore-operatedcationchannels(SOC)inendothelialcells.Weexaminedtheroleofthecaveolin-1scaffoldingdomain(CSD)inregulatingtheSOC[i.e.,transientreceptorpotentialchannel-1(TRPC1)]inhumanpulmonaryarteryendothelialcells(HPAECs).Weusedthecellpermeant...
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血清CEA、CA125及CA19-9检测在肺癌诊断中的价值
【摘要】目的探讨原发性肺癌诊断中血清CEA、CA125、及CA19-9检测的价值。方法对已确诊的56例原发性肺癌患者,追踪其CEA、CA125及CA19-9的检测结果并与35例其它肺疾患检测结果相对照。结果56例原发性肺癌中CEA阳性率为50.0%,CA125阳...
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High-ThroughputScreeningforSmall-MoleculeActivatorsofNeutrophils:IdentificationofNovelN-FormylPeptideReceptorAgonists
...orsofROSproductioninmurineneutrophils:t-butylbenzeneandthiophene-2-amide-3-carboxylicesterderivatives.Furtherstudiesoftheactivecompoundsrevealed11compoundsthatactivatedROSproductioninhumanneutrophils,andsixofthesecompoundsalsoactivatedintercellularCa2+mobilizationandchemotaxisinhumanneutrophils.Ofth...
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P2receptorregulationof[Ca2+]iinculturedmousemesangialcells
【摘要】Experimentswereperformedtoestablishthepharmacologicalprofileofpurinoceptorsandtoidentifythesignaltransductionpathwaysresponsibleforincreasesinintracellularcalciumconcentration([Ca2+]i)forculturedmousemesangialcells.Mousemesangialcellswereloadedwithfura2andexaminedusingfluorescentspectrop...
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YM-244769,aNovelNa+/Ca2+ExchangeInhibitorThatPreferentiallyInhibitsNCX3,EfficientlyProtectsagainstHypoxia/Reoxygenation-InducedSH-SY5YNeuronal
【关键词】YM-244769WeinvestigatedthepharmacologicalpropertiesandinteractiondomainsofN-(3-aminobenzyl)-6-{4-[(3-fluorobenzyl)oxy]phenoxy}nicotinamide(YM-244769),anovelpotentNa+/Ca2+exchange(NCX)inhibitor,usingvariousNCX-transfectantsandneuronalandrenalcelllines.YM-244769preferentiallyinhibitedin...