-
磷酸哌喹
药物名称磷酸哌喹药物别名磷酸喹哌,抗矽14英文名称PiperaquinePhosp说 明片剂:0.2g、0.25g、0.5g。本品为糖衣片,除去糖衣后显白色或淡黄色。功用作用本品抗疟作用与氯喹相类似。 哌喹影响伯氏疟原虫红内期裂殖体的超...
-
哌喹
药物名称哌喹药物别名磷酸哌喳,抗矽-14,13228R.P.)英文名称Piperaquine说 明片剂:每片含磷酸喹250mg。功用作用本品的抗疟作用与氯喹相类似。口服吸收后贮存于肝脏,以后缓慢释放进入血液,故作用持久。主要用于疟疾症...
-
CD14的结构和功能
CD14的结构和功能免疫学杂志2000年第1期第16卷综述与讲座作者:赵虎 周庭银 孔宪涛单位:赵虎(第二军医大学长征医院免疫中心,上海200003);周庭银(第二军医大学长征医院免疫中心,上海200003);孔宪涛(第二军医大学...
-
14-3-3蛋白
14-3-3蛋白(pdf)【摘要】14-3-3是一个在真核生物中广泛表达的酸性蛋白家族,主要以同源/异源二聚体形式存在,通过磷酸化丝/苏氨酸作用与靶蛋白或靶蛋白的两个结构域结合。七种不同亚型的高度保守的14-3-3蛋白与人类细胞中多...
-
CD14+CD34lowCellsWithStemCellPhenotypicandFunctionalFeaturesAretheMajorSourceofCirculatingEndothelialProgenitors
...pheralblood(PB)derivefromtheadhesion-relatedselectionincultureofasubsetofCD14+cells,which,whenassessedbythehighly-sensitiveantibody-conjugatedmagnetofluorescentliposomes(ACMFL)technique,werefoundtoexpressCD34.TheseCD14+CD34lowcellsrepresentedavariableproportionatindividuallevelofCD14+cells,rangingfr...
-
Excentralcleavageofß-caroteneinvivoinahealthyman
...8).Hoffman-LaRoche(Basel,Switzerland)donatedtheall-trans[10,10‘,11,11‘-14C]-ß-caroteneusedinthestudy.3Reprintsnotavailable.AddresscorrespondencetoAJClifford,3147MeyerHall,OneShieldsAvenue,DepartmentofNutrition,UniversityofCalifornia,Davis,CA95616-8669.E-mail:ajclifford{at}ucdavis.edu.ABSTRA...
-
High-andlow-affinitytransportofL-leucineandL-DOPAbytheheteroaminoacidexchangersLAT1andLAT2inLLC-PK1renalcells
...ThepresentstudyexaminedthefunctionalcharacteristicsoftheinwardandoutwardL-[14C]DOPAandL-[14C]leucinetransportersinLLC-PK1cells.UptakewasinitiatedbytheadditionofHanks‘mediumwithagivenconcentrationofL-[14C]DOPAorL-[14C]leucine.Saturationexperimentswereperformedincellsincubatedfor6minwith0.25µM...
-
Fn14IsUpregulatedinCytokine-StimulatedVascularSmoothMuscleCellsandIsExpressedinHumanCarotidAtheroscleroticPlaques
...mplicatedinthepathogenesisofatherosclerosis.WehaveanalyzedtheexpressionofFn14anditsligandTWEAKincarotidatheroscleroticplaquesanditspotentialmodulationbyatorvastatininvivo.Furthermore,wehavestudiedwhetherproinflammatorycytokinesregulateFn14expressioninhumanaorticsmoothmusclecells(hASMCs)incultureaswe...
-
UpregulatedExpressionof14-3-3ProteinsinAstrocytesFromHumanCerebrovascularIschemicLesions
...ischemia.Thepurposeofthisstudywastoinvestigatewhetheranabnormalexpressionof14-3-3proteins,anoveltypeofmolecularchaperones,occursinhumangrayandwhitematterischemiclesions.Methods—Wepreparedformalin-fixed,paraffin-embeddedsectionsfrom33autopsiedbrains,consistingof7normalcontrols,4caseswithcerebralthr...
-
PolymorphismsintheCD14GeneAssociatedwithPulmonaryFunctioninFarmers
...ienceairwayobstruction,whichmaybeattributableinparttoendotoxininhalation.CD14isareceptorforendotoxin.MaterialsandMethods:BasedonourfindingsofincreasedcirculatingCD14associatedwiththeCD14/eC159Tallele,wehypothesizedthatcarriersofthisallelewouldhavedecreasedlungfunctionamongendotoxin-exposedindividual...
-
RelationshipsamongCD14andCC16Genotypes,PlasmaLevels,andSeverity
...tswithstablediseaseandhavenotdefinedmechanismsimportantduringacuteasthma.CD14andCC16eachplayakeyroleinbiologicallyimportantinflammatorypathwaysandthegeneofeachhasafunctionalpromoter-regionpolymorphism.Objectives:Thisstudywasdesignedtodeterminetheinfluenceofthesepolymorphismsonplasmalevelsoftheirprod...
-
IdentificationandCharacterizationofaNewTubulin-BindingTetrasubstitutedBrominatedPyrrole
...ibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylicacidethylester(JG-03-14)andfoundthatitisapotentmicrotubuledepolymerizer.JG-03-14causedadose-dependentlossofcellularmicrotubules,formationofaberrantmitoticspindles,accumulationofcellsintheG2/Mphaseofthecellcycle,andBcl-2phosphorylation.Theseevents...
-
InhibitionofTNFreceptor1internalizationbyadenovirus14.7Kasanovelimmuneescapemechanism
...Cologne,UniversityofCologne,Cologne,Germany.AbstractTheadenoviralproteinE3-14.7K(14.7K)isaninhibitorofTNF-inducedapoptosis,butthemolecularmechanismunderlyingthisprotectiveeffecthasnotyetbeenexplainedexhaustively.TNF-mediatedapoptosisisinitiatedbyligand-inducedrecruitmentofTNFreceptor–associateddea...
-
DifferentialHealingActivitiesofCD34+andCD14+EndothelialCellProgenitors
...atetheirinvivoeffects.MethodsandResults-HumanCD34+primitiveprogenitorsandCD14+monocyticprogenitorswereinjectedlocallyintotheischemiclimbsofdiabeticmice.CD14+celltherapyimprovedhealingandvesselgrowth,althoughnotasrapidlyoreffectivelyasCD34+celltreatment.Westernblotanalysisrevealedthatcelltherapymodul...
-
TowardtheDevelopmentofanAntidisease,Transmission-BlockingIntranasalVaccineforGroupAStreptococcus
...ventGASinfection,aconformationallyconstrainedandminimallyconservedpeptide,J14,fromtheMproteinofGAShasbeendefined.Inthepresentstudy,J14wasformulatedwithbacterialoutermembraneproteins(proteosomes)andthenintranasallyadministeredtooutbredmicewithoutadditionaladjuvant.SuchimmunizationledtohightitersofJ14...
-
碳-14-呼气试验对胃幽门螺旋杆菌的疗效分析
【摘要】目的探讨碳-14-呼气试验(简称14C-UBT)指导药物治疗Hp具有临床应用价值。方法经胃镜和首次14C-UBT检查均为阳性的胃溃疡(26例)、浅表性胃炎(69例)、萎缩性胃炎(33例)患者共计128例,将这些患者分为3组:A组为患...
-
可溶性CD14和HCMV感染与冠心病病情变化关系
【摘要】 目的探讨可溶性CD14(sCD14)和人巨细胞病毒(HCMV)感染与冠心病(CHD)病情变化的关系。方法应用ELISA法测定120例CHD病人血清sCD14和HCMVIgG的浓度,其中急性心肌梗死(AMI)、不稳定型心绞痛(UAP)和稳定型心绞痛...
-
ProtectionofEndothelialSurvivalbyPeroxisomeProliferator-ActivatedReceptor-Mediated14-3-3Upregulation
...ticactionofcPGI2andL-165041.OurresultsshowforthefirsttimethatPGI2stimulated14-3-3expressionviaPPARactivation.cPGI2andL-165041inducedbindingoafPPARtoPPARresponseelementslocatedbetween-1426and-1477of14-3-3promoterregion,therebyactivating14-3-3promoteractivityandproteinexpression.Upregulationof14-3-3pr...
-
中国研究者对原发性肝癌p14ARF基因CpG岛甲基化研究
...中华普通外科杂志》2007年第22卷第11期中国研究者探讨了p14ARF基因启动子区CpG岛甲基化与原发性肝细胞肝癌发生、发展的关系。研究者采用逆转录-聚合酶链式反应(RT-PCR)检测42例原发性肝癌组织及癌旁组织中p14ARFmRNA的表达,同...
-
OppositelydirectedH+gradientfunctionsasadrivingforceofratH+/organiccationantiporterMATE
...edtoexistinHEK-rMATE1cells,andthetransportofvariousorganiccationsincluding[14C]tetraethylammoniumwasstimulatedinintracellularacidifiedHEK-rMATE1cellsbutnotmockcells.Thetransportof[14C]tetraethylammoniuminmembranevesiclesfromHEK-rMATE1cellsexhibitedtheovershootphenomenononlywhentherewasanoutwardlydir...
-
Afeasibilitystudyquantifyinginvivohuman-tocopherolmetabolism
...epartmentofAgriculture,ARS,BHNRC,Beltsville,MD(JAN)2Supportedbygrantno.DKRO148307,NationalCenterforResearchResourcesgrantno.RR13461fromtheNationalInstitutesofHealth,Contractno.W-7405-Eng-48fromtheUSDepartmentofEnergy(toLawrenceLivermoreNationalLaboratory),andHoffmannLaRoche.Hoffmann-LaRochedonatedth...
-
Pathogenicroleforskinmacrophagesinamousemodelofkeratinocyte-inducedpsoriasis-likeskininflammation
...hagesandgranulocytesfromtheskinofmicewithepidermis-specificdeletionofIKK2(K14-Cre-IKK2fl/flmice).Eliminationofskinmacrophagesbysubcutaneousinjectionofclodronateliposomeswasaccompaniedbyinhibitionofgranulocytemigrationintotheskinandresultedinadramaticattenuationofpsoriasis-likeskinchanges.Thehyperpro...
-
胃内酸化消除质子泵抑制剂对14C-尿素呼气试验假阴性的研究
【摘要】目的观察胃内酸化是否即刻消除质子泵抑制剂对14C-尿素呼气试验假阴性。方法35例需质子泵(PPI)治疗的Hp阳性溃疡型功能性消化不良病人口服PPI治疗7天,第6天行第二次14C-UBT检测,第7天用改良14C-UBT检测,即对正服用PP...
-
Community-WideOutbreaksofClonallyRelatedCTX-M-14-Lactamase-ProducingEscherichiacoliStrainsintheCalgaryHealthRegion
...57(55%)ofthestrainswerepositiveforblaCTX-MgenesfromtheCTX-M-IIIgroup(CTX-M-14-like).Theobjectiveofthisstudywastoinvestigatethemolecularepidemiologyofthesestrains.The-lactamaseswerecharacterized,andthegeneticrelatednessoftheisolateswasanalyzedbydigestinggenomicDNAwiththerestrictionendonucleaseXbaIand...
-
严重烧伤早期大鼠肺泡巨噬细胞CD14的表达及调控*
【摘要】目的探讨严重烧伤对大鼠肺泡巨噬细胞(AM)CD14膜蛋白(CD14)和mRNA基因表达变化的影响,以及抗CD14抗体对AM产生肿瘤坏死因子α(TNF-α)和白介素6(IL-6)的调控作用。方法20%Ⅲ度烧伤大鼠检测早期外周血内毒素(LPS)...
-
化症回生片
...,壁厚,有时一边菲薄。 草酸钙簇晶甚大,直径80~140μm。 无定形团块淡黄棕色,包埋有细小方形结晶。 花粉粒呈圆形或椭圆形,直径64~80μm,外壁呈刺状,有萌发孔三个。 (2)取本品2片,研细,加甲醇20ml,超声...
-
EnhancedLevelsofOxidizedLow-DensityLipoproteinPrimeMonocytestoCytokineOverproductionviaUpregulationofCD14andToll-LikeReceptor4inUnstableA
...itylipoprotein(oxLDL)contributestocytokineoverproductionviaupregulationofCD14andtoll-likereceptor-4(TLR-4)expressiononcirculatingmonocytesofunstableangina(UA)patients.MethodsandResults—ExpressionofCD14andTLR-4oncirculatingmonocytes,andtheconcentrationofplasmaoxLDL,(interleukin)-6,IL-1beta,IL-8...
-
14C-尿素呼气试验诊断幽门螺旋杆菌感染的研究
【摘要】目的探讨14C-尿素呼气试验在诊断幽门螺旋杆菌(Hp)感染中的价值。方法对88例因上腹不适进行胃镜检查的患者。于胃窦取黏膜组织进行组织学检测,作为标准对照,同时进行14C-尿素呼气试验(14C-UBT)。结果14C-UBT灵敏度为90....
-
DifferentialEffectsofGq,G14,andG15onVascularSmoothMuscleCellSurvivalandGeneExpressionProfiles
...yUniversitySchoolofMedicine,Atlanta,GeorgiaAbstractGqfamilymembers(Gq,G11,G14,andG15/16)stimulatephospholipaseC(PLC)andinositollipidsignalingbutdiffermarkedlyinaminoacidsequenceandtissuedistributionpredictingunappreciatedfunctionaldiversity.Toexaminefunctionaldifferences,wecomparedthesignalingproper...
-
手术中围肝门部血管急症的治疗要点
...急症的治疗方法和临床疗效。方法对10余年来笔者治疗的14例手术中围肝门部血管急症患者的临床资料进行了综合分析。结果本组中恶性肿瘤7例(50.0%),良性病变7例(50.0%)。手术中围肝门部血管急症属医源性12例(85.7%),创...