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分析|儿童癌症精准化医疗发展中的阻碍
...院达纳法伯癌症研究所及布莱根妇女医院临床主任KatherineJaneway博士带领团队进行了“个性化癌症医疗”(IndividualizedCancerTherapy,iCat)研究,旨在确定临床基因组技术能否找出可操作的变化并制定小儿晚期实体肿瘤个性化疗法,J...
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感染性心内膜炎3
...血斑,中央为白色Osler结节指(趾)垫处红紫色痛性结节Janeway损害手掌、足底无痛性出血斑※临床表现clinicalmanifestations:动脉栓塞脑心脏脾肾肠系膜四肢肺栓塞非特异性症状1脾大splenomegaly2贫血anaemia3杵状指/趾并发症complication一...
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管式胃造瘘术
...[图⑶]。⑶制成“胃管”⑷引出胃管图 管式胃造瘘术(Janeway) 5.引出“胃管” 在左侧腹直肌外缘,助缘下的腹壁上另戳一小口,其位置最好高于“胃管”的基部,以避免胃内容物外溢。通过小口引出“胃管”,其残端应...
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动脉粥样硬化免疫机制的研究进展
...的新领域。二、天然免疫模式识别理论要点美国免疫学家Janeway提出天然免疫的模式识别理论,强调天然免疫对获得性免疫的指导和调控作用,指出抗原递呈细胞(APC)是紧密地连接天然免疫与获得性免疫的桥梁。天然免疫系统...
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感染性心内膜炎2
...和趾垫出现豌豆大的红或紫红色痛性结节,亚急性多5、Janeway损害:主要见于急性,手掌、足底1-4mm的出血红斑,可能由微血管炎或微血栓所致,多非特异性6、杵状指、趾:仅见于20%的亚急性病程6周者,亦无特异性㈢其它:亚急...
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C5aandFcreceptors:amutualadmirationsociety
...isotypesofahighaffinityanti-erythrocyteautoantibody.J.Exp.Med.195::665-672.Janeway,C.J.,Travers,P.,Walport,M.J.,andShlomchik,M.J.2005.Immunobiology:theimmunesysteminhealthanddisease.GarlandScience,TaylorFrancisGroup.NewYork,NewYork,USA.823pp..作者:JohnP.Atkinson
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感染性心内膜炎95例分析
...周血管病变由于其出现的机率低(本文中出现Osler结节和Janeway结的病例分别为16和4例)。对于可疑病例应尽快完成血培养、超声心动图(UCG)甚至经食管超声心动图(TEE)检查,以期及时发现致病菌、瓣膜赘生物。对于瓣膜赘生...
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UniqueResistanceofI/LnJMicetoaRetrovirusIsDuetoSustainedInterferon–dependentProductionofVirus-neutralizingAntibodies
...iruses.J.Virol.71:3895–3903.Golovkina,T.V.,A.Chervonsky,J.C.Prescott,C.A.Janeway,andS.R.Ross.1994.ThemousemammarytumorvirusenvelopegeneproductisrequiredforsuperantigenpresentationtoTcells.J.Exp.Med.179:439–446.Golovkina,T.V.,A.Jaffe,andS.R.Ross.1994.Coexpressionofexogenousandendogenousmousemamma...
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UniqueResistanceofI/LnJMicetoaRetrovirusIsDuetoSustainedInterferon–dependentProductionofVirus-neutralizingAntibodies
...iruses.J.Virol.71:3895–3903.Golovkina,T.V.,A.Chervonsky,J.C.Prescott,C.A.Janeway,andS.R.Ross.1994.ThemousemammarytumorvirusenvelopegeneproductisrequiredforsuperantigenpresentationtoTcells.J.Exp.Med.179:439–446.Golovkina,T.V.,A.Jaffe,andS.R.Ross.1994.Coexpressionofexogenousandendogenousmousemamma...
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真菌感染的dectin-1受体识别相关研究介绍
...体迅速识别大量不同的病原体并作出应答。美国免疫学家Janeway提出了模式识别理论,将天然免疫针对主要靶分子信号称作病原相关的分子模式(Pathogen-associatedmolecularpattern,PAMP);相对应的识别受体称为模式识别受体(patternrecogn...
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感染性心内膜炎85例治疗体会
...塞,8例出现肺栓塞;一过性晕厥1例;Osler结节和(或)Janeway损害18例。 1.3实验室检查 56例病人入院时白细胞计数升高,红细胞沉降率增快43例,C反应蛋白(CRP)增高19例。肾功能损害21例,均出现镜下血尿,13例蛋白尿,7例...
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亚急性感染性心内膜炎
...ler)结节,后掌及足趾有数毫米大小的紫红色斑点,称为Janeway氏结节。临床表现大多数病例起病缓慢,低热、乏力、疲倦,少数起病急,有寒战、高热或栓塞现象,部分患者起病前有口腔手术,呼吸道感染,流产或分娩的病史...
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TOLL样受体:天然免疫和获得性免疫的桥梁
...。那么APC是如何识别病原体而启动获得性免疫反应的呢?Janeway认为可能是一类模式识别受体在起作用,目前对TLRs的大量研究证实了这一看法。病原体所特有的病原相关分子模式(PAMP)被APC上的TLRs识别后可诱导活性氧中间物(ROI...
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感染性心内膜炎
...起的小血管炎,如皮肤粘膜瘀点,指甲下出血,Osler结和Janeway损害等。感染病原体和体内产生相应的抗体结合成免疫复合物,沉着于肾小球的基底膜上,引起局灶性肾小球肾炎或弥漫性或膜型增殖性肾小球肾炎,后者可引起肾功...
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Twistingtailsexposed:theevidenceforTCRconformationalchange
...vis.2002.DirectobservationofligandrecognitionbyTcells.Nature.419:845–849.Janeway,C.A.,Jr.1995.LigandsfortheT-cellreceptor:hardtimesforaviditymodels.Immunol.Today.16:223–225.Lanier,L.L.,J.J.Ruitenberg,J.P.Allison,andA.Weiss.1986.DistinctepitopesontheTcellantigenreceptorofHPB-ALLtumorcellsidentifi...
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IL-12–andIL-23–inducedThelpercellsubsets:birdsofthesamefeatherflocktogether
....J.Immunol.151:4371–4382.Baron,J.L.,J.A.Madri,N.H.Ruddle,G.Hashim,andC.A.Janeway,Jr.1993.Surfaceexpressionofalpha4integrinbyCD4Tcellsisrequiredfortheirentryintobrainparenchyma.J.Exp.Med.177:57–68.Khoury,S.J.,W.W.Hancock,andH.L.Weiner.1992.Oraltolerancetomyelinbasicproteinandnaturalrecoveryfromex...
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MyD88-dependentinductionofallergicTh2responsestointranasalantigen
...A.H.,andFreeman,G.J.2002..TheB7-CD28superfamily.Nat.Rev.Immunol.2::116-126.Janeway,C.A.Jr.,andMedzhitov,R.2002..Innateimmunerecognition.Annu.Rev.Immunol.20::197-216.Janeway,C.A.Jr.1989..Approachingtheasymptote?Evolutionandrevolutioninimmunology.ColdSpringHarb.Symp.Quant.Biol.54::1-13.Takeda,K.,Kaish...
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Interleukin-1receptor-associatedkinase-1playsanessentialroleforToll-likereceptor(TLR)7-andTLR9-mediatedinterferon-induction
...tyforthePromotionofScienceforYoungScientists.ReferencesMedzhitov,R.,andC.J.Janeway.1997.Innateimmunity:thevirtuesofanonclonalsystemofrecognition.Cell.91:295–298.Takeda,K.,T.Kaisho,andS.Akira.2003.Toll-likereceptors.Annu.Rev.Immunol.21:335–376.Akira,S.,andK.Takeda.2004.Toll-likereceptorsignalling...
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ThePoxvirusProteinA52RTargetsToll-likeReceptorSignalingComplexestoSuppressHostDefense
...142.Medzhitov,R.,P.Preston-Hurlburt,E.Kopp,A.Stadlen,C.Chen,S.Ghosh,andC.A.Janeway.1998.MyD88isanadaptorproteininthehToll/IL-1receptorfamilysignalingpathways.Mol.Cell.2:253–258.Wesche,H.,W.J.Henzel,W.Shillinglaw,S.Li,andZ.Cao.1997.MyD88:AnadapterthatrecruitsIRAKtotheIL-1receptorcomplex.Immunity.7:...
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ThePoxvirusProteinA52RTargetsToll-likeReceptorSignalingComplexestoSuppressHostDefense
...142.Medzhitov,R.,P.Preston-Hurlburt,E.Kopp,A.Stadlen,C.Chen,S.Ghosh,andC.A.Janeway.1998.MyD88isanadaptorproteininthehToll/IL-1receptorfamilysignalingpathways.Mol.Cell.2:253–258.Wesche,H.,W.J.Henzel,W.Shillinglaw,S.Li,andZ.Cao.1997.MyD88:AnadapterthatrecruitsIRAKtotheIL-1receptorcomplex.Immunity.7:...
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SecondClassMinors
...l.8:271–277.Rudensky,A.Y.,P.Preston-Hurlburt,S.-C.Hong,A.Barlow,andC.A.J.Janeway.1991.SequenceanalysisofpeptidesboundtoMHCclassIImolecules.Nature.353:622–627.Engelhard,V.H.1994.StructureofpeptidesassociatedwithclassIandclassIImolecules.Annu.Rev.Immunol.12:181–207.Rammensee,H.G.,J.Bachmann,andS...
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SecondClassMinorsMolecularIdentificationoftheAutosomalH46HistocompatibilityLocusasaPeptidePresentedbyMajorHistocompatibilityComplexClassII
...l.8:271–277.Rudensky,A.Y.,P.Preston-Hurlburt,S.-C.Hong,A.Barlow,andC.A.J.Janeway.1991.SequenceanalysisofpeptidesboundtoMHCclassIImolecules.Nature.353:622–627.Engelhard,V.H.1994.StructureofpeptidesassociatedwithclassIandclassIImolecules.Annu.Rev.Immunol.12:181–207.Rammensee,H.G.,J.Bachmann,andS...
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第六节 感染性心内膜炎
...ler)结节,后掌及足趾有数毫米大小的紫红色斑点,称为Janeway氏结节。 临床表现 大多数病例起病缓慢,低热、乏力、疲倦,少数起病急,有寒战、高热或栓塞现象,部分患者起病前有口腔手术,呼吸道感染,流产或分...
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Toll-likereceptor9mediatesinnateimmuneactivationbythemalariapigmenthemozoin
...olymorphismandprospectsforintervention.Ann.Trop.Med.Parasitol.91:533–542.Janeway,C.A.,Jr.,andR.Medzhitov.2002.Innateimmunerecognition.Annu.Rev.Immunol.20:197–216.Akira,S.,andK.Takeda.2004.Toll-likereceptorsignalling.Nat.Rev.Immunol.4:499–511.Adachi,K.,H.Tsutsui,S.Kashiwamura,E.Seki,H.Nakano,O....
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Tcellreceptorengagementbypeptide–MHCligandsinducesaconformationalchangeintheCD3complexofthymocytes
...03.TritopemodelofrestrictiverecognitionbytheTCR.TrendsImmunol.24:127–131.Janeway,C.A.,Jr.1995.LigandsfortheT-cellreceptor:hardtimesforaviditymodels.Immunol.Today.16:223–225.Hennecke,J.,andD.C.Wiley.2001.Tcellreceptor-MHCinteractionsupclose.Cell.104:1–4.Reiser,J.B.,C.Gregoire,C.Darnault,T.Mosse...
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RNA-associatedautoantigensactivateBcellsbycombinedBcellantigenreceptor/Toll-likereceptor7engagement
...chInstitute(toI.R.Rifkin).ReferencesMedzhitov,R.,P.Preston-Hurlburt,andC.A.Janeway.1997.AhumanhomologueoftheDrosophilaTollproteinsignalsactivationofadaptiveimmunity.Nature.388:394–397.Leadbetter,E.A.,I.R.Rifkin,A.H.Hohlbaum,B.Beaudette,M.J.Shlomchik,andA.Marshak-Rothstein.2002.Chromatin-IgGcomplex...
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YellowfevervaccineYF-17DactivatesmultipledendriticcellsubsetsviaTLR2,7,8,and9tostimulatepolyvalentimmunity
...erivedfromthecelllinesinwhichthevaccinesweregrown.Suchcellularcontaminants(Janeway‘s“dirtylittlesecrets“[reference76]orMatzinger‘s“dangersignals“[reference77]),maywellplayimportantrolesintheinductionandmodulationofvaccineinducedimmuneresponses.Thus,thechickenembryosandcelllinesinwhichYF-...
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Toll-likereceptor–independentgeneinductionprogramactivatedbymammalianDNAescapedfromapoptoticDNAdegradation
...uestionsandpossibilitiesinToll-likereceptorsignalling.Nature.430:257–263.Janeway,C.A.,Jr.,andR.Medzhitov.2002.Innateimmunerecognition.Annu.Rev.Immunol.20:197–216.Sakahira,H.,M.Enari,andS.Nagata.1998.CleavageofCADinhibitorinCADactivationandDNAdegradationduringapoptosis.Nature.391:96–99.Hanayama...
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InhibitionofInterleukin1Receptor/Toll-likeReceptorSignalingthroughtheAlternativelySpliced,ShortFormofMyD88IsDuetoItsFailuretoRecruitIRAK
...eptorcomplex.Immunity.7:837–847.Kobayashi,K.,L.D.Hernandez,J.E.Galan,C.A.Janeway,Jr.,R.Medzhitov,andR.A.Flavell.2002.IRAK-MisanegativeregulatorofToll-likereceptorsignaling.Cell.110:191–202.Sato,S.,F.Nomura,T.Kawai,O.Takeuchi,P.F.Muhlradt,K.Takeda,andS.Akira.2000.Synergyandcross-tolerancebetweent...
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InhibitionofInterleukin1Receptor/Toll-likeReceptorSignalingthroughtheAlternativelySpliced,ShortFormofMyD88IsDuetoItsFailuretoRecruitIRAK
...eptorcomplex.Immunity.7:837–847.Kobayashi,K.,L.D.Hernandez,J.E.Galan,C.A.Janeway,Jr.,R.Medzhitov,andR.A.Flavell.2002.IRAK-MisanegativeregulatorofToll-likereceptorsignaling.Cell.110:191–202.Sato,S.,F.Nomura,T.Kawai,O.Takeuchi,P.F.Muhlradt,K.Takeda,andS.Akira.2000.Synergyandcross-tolerancebetweent...