与PER相关的文献报道

生物钟基因的一些非生物钟效应研究进展

...1生物钟基因研究概况　　总体来说,生物的昼夜节律是由PER和TIM、CLOCK和BMAL1等4个生物钟“齿轮组成的正负调节回路控制的。它们通过PAS域分别形成异型二聚体进入核内,调节Per和Tim的转录,从而使得Per和TimmRNA呈现周期波动。CLOC...

苏州大学利用TALEN技术研究斑马鱼生物钟

...iologicalChemistry》发表一项最新研究成果，题为“ThezebrafishPeriod2proteinpositivelyregulatesthecircadianclockthroughmediationofRAR-relatedorphanreceptoralpha(Rorα)”。在这项研究中，研究人员利用TALEN技术，成功制备了两种斑马鱼per2无效突变体，阐明了...

DisruptionofClockGeneExpressionAltersResponsesoftheArylHydrocarbonReceptorSignalingPathwayintheMouseMammaryGland

...onThebiologicaleffectsofmanyenvironmentaltoxinsaremediatedbygenescontainingPer-Arnt-Sim(PAS)domains,thearylhydrocarbonreceptor(AhR),andAhRnucleartranslocator.BecausethesetranscriptionfactorsinteractwithotherPASgenesthatformthecircadianclockworksinmammals,wedeterminedwhethertargeteddisruptionoftheclo...

研究证实：熬夜反应差异与PER3基因有关

...洲科研人员最新的研究证实，这种差异实际上和一个名为PER3的基因有关。　　来自比利时和英国的研究人员在24日出版的《神经学杂志》上报告说，此前的研究就发现PER3基因与人缺觉后的反应有关，这个基因分为长版和短版两...

欧洲科研研究表明：熬夜反应与PER3基因有关

...洲科研人员最新的研究证实，这种差异实际上和一个名为PER3的基因有关。　　来自比利时和英国的研究人员在24日出版的《神经学杂志》上报告说，此前的研究就发现PER3基因与人缺觉后的反应有关，这个基因分为长版和短版两...

揭开“早睡早起”基因的秘密

...内生物钟是如何提早“完工”的。小鼠的研究表明，如果Period2(Per2)时钟基因（**）发生突变，原本可以通过化学修饰调控该蛋白的酶则不再起作用。这种调控功能的丧失导致Per2蛋白表达下降，睡眠模式也发生了特征性地变化。...

AssociationBetweenSerumUricAcid,MetabolicSyndrome,andCarotidAtherosclerosisinJapaneseIndividuals

...ariateanalysisIntroductionPreviousepidemiologicalstudieshavesuggestedthathyperuricemiamaybeariskfactorforcardiovasculardiseases.1–3Possibleexplanationsforthislinkmayincludeelevationofuricacid,anaturalantioxidant4,5asadefensemechanismagainstadvancedatherosclerosis,6orhyperuricemia-inducedendothelia...

熬夜反应与基因有关

...洲科研人员最新的研究证实，这种差异实际上和一个名为PER3的基因有关。此前的研究就发现PER3基因与人缺觉后的反应有关，这个基因分为长版和短版两种。拥有短版PER3基因的人熬夜后认知能力仍然如常，显示对睡眠缺乏的承受...

IsItTimeforaLarge,CollaborativeStudyofPediatricStroke

...ightcasesofpediatricstrokewereidentified,yieldinganannualincidencerateof4.3per100000(95%CI,1.9to8.5).Therewere5casesofintracerebralhemorrhage,1subarachnoidhemorrhage,1ischemicstroke,and1transientischemicattack.AlloftheeventsoccurredinMAs.Dependingontheprevalenceoftheriskfactorsofinterest,futurestudi...

ModelingtheFutureBurdenofStrokeintheNetherlands

...strokepatientsduetodemographicchangesandtrendsintheprevalenceofsmokingandhypertensionintermsoftheprevalence,incidence,andpotentialyearsoflifelostmightbe.Methods—Adynamic,multistatelifetablewasused,whichcombineddemographicprojectionsandexistingstrokemorbidityandmortalitydata.Itprojectedfuturechange...

生物钟基因可能是连接情绪和睡眠的关键

...这些家庭成员另外的共同之处是他们都携带有错误版本的PER3生物钟基因。为了探究这种基因在个体季节性情感障碍中的作用，研究者使小鼠携带了两个有缺陷的PER3基因。与人类不同，小鼠通常在白天睡觉，夜间活动。科学家通...

InvasiveGroupAStreptococcalDiseaseinAlberta,Canada(2000to2002)

...wastodeterminetheincidenceratesofiGASinfectionsthroughoutAlbertaovera3-yearperiod(2000to2002)andtobetterunderstandtheepidemiologyofiGASinthisprovince.Therewereatotalof441casesofinvasiveGASdiseaseoverthe3yearsexamined(averagepopulationover3years,3,055,765)and47deaths.TheincidenceinAlbertawas5.0(2000)...

TrendsintheuseofPartIIoftheMentalHealthAct1983insevenEnglishlocalauthorityareas

...andardisedtoage,genderandethnicity-specificpopulations.ResultsOverthe8-yearperiodtheoverallrateofdetentionunderPartIIincreasedby32%.Itincreasedinallthreemajorethnicgroupings;therateofincreasewasgreaterformenthanforwomen(38%v.26%)and,inparticular,foryoungermencomparedwithyoungerwomen(43%v.28%).Conclu...

GeographicVariationsinStrokeIncidenceandMortalityAmongOlderPopulationsinFourUSCommunities

...iteddataongeographicvariationsinstrokeincidenceamongolderUSpopulationswhoexperiencethemajorityofstrokeburden.Thepurposeofthisstudywastocomparestrokeincidenceandmortalityratesin4UScommunities.Methods—ParticipantsintheCardiovascularHealthStudy(CHS)whohadnohistoryofstrokeatbaseline(n=5639)werefollowe...

InfluenceofDietaryPatternsonStrokeRiskinChina

...ndoilsbetween1978and19923andadecreaseinfruitandvegetableintakeduringthesameperiod.3ThiscorrelationholdstrueforstrokeinChina(B.F.Zhou,personalcommunication,September12,2004).ZhoupresentedfurtherconfirmatorydatafromtheInternationalStudyonMacronutrientsandBloodPressure(INTERMAP)inaChinesemedicaljournal...

RelationofthetocopherolformstoincidentAlzheimerdiseaseandtocognitivechange

...edbymixedmodelsin3718participants.HigherintakesofvitaminE(relativerisk:0.74per5mg/dincrease;95%CI:0.62,0.88)and-tocopherolequivalents(relativerisk:0.56per5mg/dincrease;95%CI:0.32,0.98)wereassociatedwithareducedincidenceofAlzheimerdiseaseinseparatemultiple-adjustedmodelsthatincludedintakesofsaturated...

IncidenceofRecurrentSubarachnoidHemorrhageAfterClippingforRupturedIntracranialAneurysms

...l[CI],1.5%to4.9%)andtheincidencerate286of100000patient-years(95%CI,160to472per100000).Riskfactorsweresmoking(hazardratio[HR],6.5;95%CI,1.7to24.0),age(HR,0.5per10years;95%CI,0.3to0.8)andmultipleaneurysmsatthetimeoftheinitialSAH(HR,5.5;95%CI,2.2to14.1).Conclusions—AfterSAH,theincidenceofarecurrencew...

2．7食物蛋白质

...作更为简便。　　（4）蛋白质效力比（proteinefficiencyratio,PER）蛋白质效力比是摄入单位重量蛋白质的体重增加数：　　PER=体重增加（g）/摄入蛋白质（g）　　通常用雄性断乳大鼠为实验对象。Osborne等证明PER随饲料中蛋白质的水...

IncidenceandseverityofkeratoconusinAsirprovince,SaudiArabia

...dfromreferralstothedepartmentofophthalmology,AsirCentralHospital,overa1yearperiod.Age,visualacuity,andkeratometrywererecordedalongwithclinicalsignsandsymptoms.Results:TheincidenceofkeratoconusinAsirProvinceis20casesper100000population.Also,thediseaseseverityishigh,asindicatedbyanearlymeanage(17.7(3....

Effectofpotassium-enrichedsaltoncardiovascularmortalityandmedicalexpensesofelderlymen

...ans.Design:Fivekitchensofaveteranretirementhomewererandomizedinto2groups(experimentalorcontrol)andveteransassignedtothosekitchensweregiveneitherpotassium-enrichedsalt(experimentalgroup)orregularsalt(controlgroup)for31mo.Informationondeath,healthinsuranceclaims,anddatesthatveteransmovedinoroutoftheho...

TheepidemiologyofoculartraumainruralNepal

...xaminationandinterviewedaboutthecontextoftheirinjury.Followupexaminationwasperformed2–4monthsaftertheinitialinjury.Results:525casesofincidentocularinjurywerereported,withameanageof28years.Usingcensusdata,theincidencewas0.65per1000malesperyear,and0.38per1000femalesperyear.Themostcommontypesofinjury...

生产前的叶酸会影响神经管缺陷发生率

...owerthaninPuertoRico,wheremostresidentsareHispanic,andwhereprevalenceis8.68per10,000livebirths.UsingdatafromtheBirthDefectsSurveillanceSystem(BDSS)for1996to2005andtheBehavioralRiskFactorSurveillanceSystem(BRFSS)for1997to2006,theinvestigatorsanalyzedtrendsinprevalenceofNTDandinknowledgeandconsumption...

LowbirthweightintheUnitedStates

...heinfantatgreaterriskoflateradultchronicmedicalconditions,suchasdiabetes,hypertension,andheartdisease.Ofinterest,maternalthinnessisastrongpredictorofbothpretermbirthandfetalgrowthrestriction.However,intheUnitedStates,severalnutritionalinterventions,includinghigh-proteindiets,caloricsupplementation,c...

TheThirdStrokeRegistryinTartu,Estonia

...Atotalof1280patientswithfirst-everstrokewereregisteredduringthe5-yearstudyperiod.Theoverallincidencerateof230per100000declinedbetweenthestudiesto188per100000age-standardizedtotheEuropeanstandardpopulation.Theage-adjustedincidencerateforwomendecreasedfrom204to164per100000betweenthe2periods.Inmostofth...

CharacteristicsofBloodPressureProfilesasPredictorsofLong-TermOutcomeAfterAcuteIschemicStroke

...tudiedthe615patientswithacuteischemichemisphericstrokeinthefirstEuropeanCooperativeAcuteStrokeStudy(ECASS).BPwasmeasuredat2-hourintervalsduringthefirst20hoursafterrandomization,andthenevery4hours,upto72hoursafteradmission.Studiedfeaturesofindividual0-to72-hourBPprofileswere:baselineBP,maximumandmini...

哈尔滨市香坊区1997-2006年0～14岁儿童死亡原因分析

...angfangDistrictofHarbinforthefutureinterventions.MethodsDescriptivestudywasperformedthroughanalyzingthedeathsurveillancedataof0-14childreninXianfangDistrictofHarbinfrom1997to2006.ResultsItshowedthattheaverageannualmortalitywas68.82per100000,whilemortalityofboys（79.44per100000）washigherthanthatof...

《Science》、《Cell》三篇文章介绍同一个生理节奏基因

...和翻译的反馈环产生的。转录因子CLOCK和BMAL1驱动钟基因Period(Per)和Cryptochrome(Cry)表达，这两种基因表达的蛋白与CLOCL和BMAL1相互作用，抑制它们的转录。PER和CRY蛋白降解，抑制作用下降，转录重新开始。回路中有延滞（Delays），以...

Segment-SpecificEffectsofCardiovascularRiskFactorsonCarotidArteryIntima-MedialThicknessinWomenatMidlife

...pendently(P0.05)andpositivelyassociatedwereasfollows:baselineweight(?=0.007per5kg),systolicbloodpressure(SBP;?=0.008per10mmHg),andage(?=0.02per5years)withCCAIMT;smoking(?=0.08),weight(?=0.009),andSBP(?=0.02)withbulbIMT;andapoproteinB(?=0.01per0.1g/L)withICAIMT.Differentialeffectsinarepeatedmeasuresm...

AdenoviralGeneTransferofFGF-5toHibernatingMyocardiumImprovesFunctionandStimulatesMyocytestoHypertrophyandReentertheCellCycle

...dium,butflowduringadenosinewasunchanged(LAD1.45±0.27versus1.46±0.23mL/minpergandremote4.84±0.23versus4.71±0.47mL/minperg,P=NS).Unexpectedly,animalsreceivingAdvFGF-5demonstrateda29%increaseinLVmassoverthe2-weekperiod(P0.05versusuntreatedanimalswithhibernatingmyocardiumandnormalshams).Histological...

SeminationalSurveillanceofFungemiainDenmark:NotablyHighRatesofFungemiaandNumbersofIsolateswithReducedAzoleSusceptibility

...I),andalthoughC.albicansisthepredominantspeciesonbothsidesoftheAtlantic,thepercentagevaries,being50%intheUnitedStatesandSpain,over56%inarecentEuropeanstudycoveringFrance,Germany,Austria,Spain,Sweden,andtheUnitedKingdom,and70%inarecentstudyinFinland(1,5,18,20,21,25).Thedistributionofnon-C.albicansspe...