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动物所研究发现cAMP/PKA信号对神经病靶酯酶的调节作用
神经病靶酯酶(neuropathytargetesterase,NTE)是在研究有机磷化合物(OP)引发人和敏感动物出现有机磷诱发的迟发性退行性病变(OP-induceddelayedneuropathy,OPIDN)时发现的。OPIDN发生时,由于脊髓和周围神经的长轴突退变而导致下肢麻...
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研究发现神经病靶酯酶自噬溶酶体降解途径
神经病靶酯酶(neuropathytargetesterase,NTE)是在研究有机磷引起的迟发性神经病(organophosphate-induceddelayedneuropathy,OPIDN)的机理的过程中被发现的。NTE被认为是诱导OPIDN发生的起始靶标。研究证明,NTE是一种内质网上的跨膜蛋白,...
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伍一军在《AppliedMicrobiologyandBiotechnology》上发表最新研究成果
...有机磷杀虫剂引起OPIDN的主要靶标蛋白-神经毒性酯酶(NTE)并非神经细胞分化所必需,但却在神经生长发育过程中起着重要的辅助作用。NTE的过表达可以引起细胞周期阻滞。NTE蛋白可通过泛素蛋白酶体途径降解,也可通过溶酶...
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有机磷迟发性神经毒性的动物敏感性差异与神经系统磷脂酶抑制模式有关
...磷脂酶(LysoPLA)和磷脂酶B(PLB)活性的神经病靶酯酶(NTE)被认为是OPIDN的主要靶标。OPIDN的发生具有动物种属敏感性差异:成年鸡在对神经毒性OP的易感性以及随后表现出来的毒性症状方面与人极为相似,故其一直被用作研究O...
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有机磷农药中毒并迟发性神经炎2例
...病,主要机制是有机磷抑制神经组织中的神经病靶酯酶(NTE)并使其老化,从而产生迟发性神经炎。主要临床表现为感觉运动型多发性神经炎,感觉异常表现为肢体麻木、疼痛,逐渐向肢体近端发展,运动障碍表现为肢体无力、...
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Fattydietsareunhealthyeventhosebasedonmonounsaturates
...tudybyKris-Ethertonetalandinmostearliertrialscomparingdietswithvariousfatcontents,energyintakewasfixedandconstant(ie,isoenergeticconditionsweremaintained)tokeepbodyweightconstant.Thisdesignisinappropriatebecausespontaneousenergyintakewouldnormallydifferifdietswithdifferentfatcontentswereeatenadlibit...
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血站Rh阴性血浆抗体筛查结果分析
...术出版社,2002:58~68.作者单位:(YangzhouMunicipalRedcoressBloodCente,Yangzhou225012,Jiangsu,P.R.China)作者:骆钧,范恩勇,孙海英,郭铭华
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原发肿瘤和复发肿瘤的乳癌分子显型不同
...rtantfactorinoptimizingtreatment,sheadded,andfurtherstudyofthisissueiswarranted.Thisstudyaddress3ofthebiomarkersusedintheclinic,whichcurrentlyguideourchoiceoftreatment,saidPaulE.Goss,MD,PhD,directorofBreastCancerResearchatMassachusettsGeneralHospital,inBoston,inadiscussionofthestudy.Thequestionputbe...
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美国新规推动抗生素研究发飚
...这种技术的最前沿。去年1月,TheraEDGE开展了一个项目。NTE公司生物医学领域的管理者、同时也是该项目的协调者JordiCarrera表示,该项目是利用分子诊断装置在20分钟内确定导致社区获得性下呼吸道感染致病菌,而当前的诊断方法...
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EsculeogeninA,aNewTomatoSapogenol,AmelioratesHyperlipidemiaandAtherosclerosisinApoE-DeficientMicebyInhibitingACAT
...dash;WerecentlyidentifiedesculeosideA,anewspirosolane-typeglycoside,withacontentintomatoesthatis4-foldhigherthanthatoflycopene.Inthepresentstudy,weexaminedtheeffectsofesculeosideAandesculeogeninA,anewaglyconofesculeosideA,onfoamcellformationinvitroandatherogenesisinapoE-deficientmice.MethodsandResul...
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RadiationInducesEndothelialDysfunctioninMurineIntestinalArteriolesviaEnhancedProductionofReactiveOxygenSpecies
...adiationinducesacutemicrovasculardysfunctionintheresistancearteriolesoftheintestine.EnhancedROScontributetothisdysfunctionandthereforemayrepresentanoveltherapeutictargettominimizeradiationtoxicityinthegut.Inirradiatedgutfromrats,aprofoundmicrovascularendothelialdysfunctionwasdemonstrated.Excesslevel...
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Photodynamictherapyofcircumscribedchoroidalhaemangioma
...eEyeInstitute,ClevelandClinicFoundation,Cleveland,OH,USA2ClinicalResearchCenter,ColeEyeInstitute,ClevelandClinicFoundation,Cleveland,Ohio,USA3RetinaService,ColeEyeInstitute,ClevelandClinicFoundation,Cleveland,OH,USA4DepartmentofOphthalmology,RoyalHallamshireHospital,Sheffield,UKABSTRACTAim:Toevaluat...
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卵巢平滑肌瘤临床病理分析
...ngfasciclesofuniform.Tumorcellwasspindle-shapedandhadelongatednucleiwithbluntend.Ithadfinely.dispersedchromatinandsmallnucleoli.Mitoticfiguresusuallywereinfrequente(1/10HPF).Massonstainingshowedthecytoplasmoftumorcellwasred.Immunohistochemicalstainingshowedthetumorcellswerepositiveexpressionford...
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有机磷杀虫剂中毒与标志酶
...mPharmacol,1990,40:2587~2596. 7.BertolazziM,CaroldiS,MorettoA,etal.Interactionofmethamidophoswithhenandhumanacetylcholinesteraseandneuropathytargetesterase.Archtoxicol,1991,65:580~585. 8.PopeCN,TanakaD,PadillaS.Theroleofneurotoxicesterase(NTE)inthepreventionandpotentiationoforganophosp...
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babA2-andcagA-PositiveHelicobacterpyloriStrainsAreAssociatedwithDuodenalUlcerandGastricCarcinomainBrazil
...ofPathology,FaculdadedeMedicina,UniversidadeFederaldeMinasGerais,BeloHorizonte,Brazil2Received16April2003/Returnedformodification28May2003/Accepted1June2003 ABSTRACTTopAbstractTextReferencesThebabA2andcagAgeneswereinvestigatedin208BrazilianHelicobacterpyloristrains.AstrongassociationbetweenbabA2an...
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HeterogeneityamongStrainsofDiffuselyAdherentEscherichiacoliIsolatedinBrazil
...versityofMaryland,Baltimore,MarylandABSTRACTOnehundredtwelvediffuselyadherentEscherichiacolistrainsisolatedfromchildreninacasecontrolstudywereevaluatedforvirulence-associatedcharacteristics,serotyping,antibioticresistance,andplasmidprofiles.HalfofthestrainshybridizedwiththeprobesforicuA(aerobactin)a...
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Costeffectivenessofphotodynamictherapywithverteporfinforagerelatedmaculardegeneration:theUKcase
Serieseditors:MelissaandGaryBrown1KaiserPermanente,CenterforHealthResearch,PortlandOregon,USA,CentreforHealthEconomics,UniversityofYork,York,UK2NottinghamUniversityBusinessSchool,Nottingham,UK3CentreforHealthEconomics,UniversityofYork,York,UKABSTRACTAim:Toestimatethepotentialcosteffectivenessofphoto...
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3DUltrasoundMeasurementofChangeinCarotidPlaqueVolume
...rpose—Newtherapiesarebeingdevelopedthatareantiatheroscleroticbutthatlackintermediateendpoints,suchaschangesinplasmalipids,whichcanbemeasuredtotestefficacy.Tostudysuchtreatments,itwillbenecessarytodirectlymeasurechangesinatherosclerosis.Thestudywasdesignedtodeterminesamplesizesneededtodetecteffects...
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RAGEExpressioninRhabdomyosarcomaCellsResultsinMyogenicDifferentiationandReducedProliferationMigrationInvasivenessandTumorGrowth
...udingmyoblastfusionintomyotubes,theprecursorsofmaturemyofibers.1-11Inthiscontext,extracellularsignal-regulatedkinases1and2(ERK1/2)andc-JunNH2terminalproteinkinase(JNK)needtobeinactivated,andp38mitogen-activatedproteinkinase(MAPK)andAktneedtobeactivatedformyoblaststoexitthecellcycleandfordifferentiat...
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SecondClassMinors
...aryoftargetcellgenes.ThemurineH46locusonchromosome7wasthusfoundtoencodetheinterleukin4–inducedIL4i1gene.TheIL4i1precursorcontainstheHAFVEAIPELQGHVpeptidewhichispresentedbyAbmajorhistocompatibilitycomplexclassIImoleculeviaanendogenouspathwayinprofessionalantigenpresentingcells.Bothallelicpeptidesbi...
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SecondClassMinorsMolecularIdentificationoftheAutosomalH46HistocompatibilityLocusasaPeptidePresentedbyMajorHistocompatibilityComplexClassII
...aryoftargetcellgenes.ThemurineH46locusonchromosome7wasthusfoundtoencodetheinterleukin4–inducedIL4i1gene.TheIL4i1precursorcontainstheHAFVEAIPELQGHVpeptidewhichispresentedbyAbmajorhistocompatibilitycomplexclassIImoleculeviaanendogenouspathwayinprofessionalantigenpresentingcells.Bothallelicpeptidesbi...
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Associationbetweenfruitandvegetableconsumptionandoralcancer:ameta-analysisofobservationalstudies
...hetypeofcancersincluded,citrusfruitandgreenvegetableconsumption,andthetimeintervalfordietaryrecallofthestudiesontheroleoffruitorvegetableconsumptionintheriskoforalcancer.Thepresenceofpublicationbiaswasassessedwithafunnelplotforasymmetry.Results:Sixteenstudies(15case-controlstudiesand1cohortstudy)met...
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我国职业中毒临床及科研工作50年进展
...动型周围神经病,ChE抑制作用不明显,检查神经病靶酯酶(NTE)活力有助于诊断。 (二)慢性中毒: 1.铅:我国对铅中毒的防、治、研做了大量工作。90年代起,全国17个单位协作,对血铅、血红细胞游离原卟啉、红细胞锌原卟...
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AnalysisofaUropathogenicEscherichiacoliClonalGroupbyMultilocusSequenceTyping
...dImmunity,UniversityofCaliforniaatBerkeley,Berkeley,CaliforniaDepartmentofIntegrativeBiology,UniversityofCaliforniaatBerkeley,Berkeley,CaliforniaDepartmentofEpidemiology,Biostatistics,andOccupationalHealth,McGillUniversity,Montreal,Quebec,CanadaDivisionofEpidemiology,SchoolofPublicHealth,Universityo...
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CumulativeEffectofPredisposingGenotypesandTheirInteractionWithModifiableFactorsontheRiskofIschemicStrokeinYoungAdults
...groundandPurpose—Combinationsofmultiplepredisposingpolymorphismsandtheirinteractionswithmodifiablefactorsmayresultinsynergisticeffectsontheriskofischemicstroke.Thesemechanismsaremorelikelytoplayarelevantroleinyoungerindividuals.Methods—Thecumulativeeffectofthe20210Avariantofprothrombingene,the16...
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Sugarsandsatiety:doesthetypeofsweetenermakeadifference?
...takesatthenextmealwiththeuseofawithin-subjectdesign.Design:Thirty-sevenvolunteers(19men,18women)aged2029yconsumedisocaloriccolabeverages(215kcal)sweetenedwithsucrose,HFCS42,orHFCS55.HFCS42contains42%fructose,andHFCS55contains55%fructose.Dietcola(2kcal),1%-fatmilk(215kcal),andnobeveragewerethec...
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DietaryintakeandnutritionalstatusofyoungvegansandomnivoresinSweden
...ethicalratherthanhealthreasons.Thismayresultinhealthproblemscausedbylackofinterestinandknowledgeofnutrition.Objective:WecomparedthedietaryintakeandnutritionalstatusofyoungSwedishvegansandomnivores.Design:Thedietaryintakesof30vegans(15malesand15females;meanage:17.5±1.0y)and30sex-,age-,andheight-...
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OutbreakofInfectionCausedbyEnterobactercloacaeProducingtheNovelVEB-3Beta-LactamaseinChina
CenterofLaboratoryMedicineofHuashanHospital,ShanghaiMedicalCollege,FudanUniversityDepartmentofClinicalMicrobiology,RijinHospital,ShanghaiSecondMedicalUniversityDepartmentofClinicalLaboratoryoftheSixthPeople‘sHospitalofShanghai,Shanghai,People‘sRepublicofChinaABSTRACTOvera4-monthperiodfromNovembe...
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Immunonutrition:problematicorproblemsolving?
KarenCMcCowenandBruceRBistrian1FromtheBethIsraelDeaconessMedicalCenterandHarvardMedicalSchool,Boston.2SupportedbyagrantfromtheAmericanLiverFoundation(toKCM).3AddressreprintrequeststoBRBistrian,BethIsraelDeaconessMedicalCenter,WestCampus,1DeaconessRoad,Boston,MA02215.E-mail:bbistria{at}caregroup.harv...
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Nutrition,mildhyperparathyroidism,andbonemineraldensityinyoungJapanesewomen
...donthebasisofdietarynitrogenmeasuredbythemicro-Kjeldahlmethod.Theintra-andinterassayCVswere1.1%and2.6%,respectively,forcalcium,1.4%and0.8%forphosphorus,1.5%and1.3%forsodium,2.8%and5.2%forpotassium,and1.5%and0.7%forprotein.Thetotaldryweightofamealwasassumedtoreflectitstotalenergycontent.Tovalidatethi...