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尼尔雌醇研究应用新进展
摘要 综述了尼尔雌醇(CEE3)近几年来的实验研究、应用概况,主要包括抗辐射研究、骨质疏松研究及治疗更年期综合征、降血脂、摘取节育器的结果。 尼尔雌醇(Nilestriol)是雌三醇长效制剂,口服吸收后贮存于脂肪组织,在体...
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绝经期的激素替代治疗会增加女性发生尿失禁的风险
...1年的尿失禁。随机分为三组,分别服用雌激素+黄体酮(CEE+MPA)、单用雌激素(CEE)和安慰剂。结果发现,绝经期激素替代治疗会增加尿失禁的发生率。其中发生压力性尿失禁的风险最高(CEE+MPA组:1.87倍,CEE组:2.15倍),其次为...
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尼尔雌醇用于绝经后取器66例临床分析
...的结缔组织中有1%的弹力纤维,其余几乎都是胶原纤维。CEE3对阴道和子宫颈管具有选择性作用,而对子宫实体及子宫内膜并无影响,能促进阴道黏膜血管新生和阴道上皮损伤愈合,同时能增强子宫颈细胞功能,使子宫颈肌纤维增...
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激素替代对猴宫骶韧带和圆韧带生物力学特性的影响
...研究了卵巢切除术(OVX)和共轭马雌激素加宫安黄体酮(CEE/MPA)或乙炔基雌二醇加炔诺酮(EE/NA)对绝经后(PMP)猴宫骶韧带(USL)及圆韧带(RL)生物力学特性的影响。在这项随机三盲安慰剂对照研究中,OVX猴分别接受12个月...
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女性更年期泌尿生殖系统症状的激素替代治疗研究
...状[7]。(1)结合雌激素阴道乳膏。每克乳膏含结合雌激素(CEE)0.625mg。前2周连续每晚使用0.3mgCEE,此后6个月每周使用3次,从症状及细胞学方面均可逆转阴道萎缩[7]。如阴道上皮欲达到相似的效果,口服CEE需要较高剂量。提示局部用...
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波兰欲成为生物技术强国情况分析
波兰拥有约3800万人口,这让其成为中东欧地区(CEE)最大的医药消费市场。然而,波兰本国的制药业在对外出口的规模和国际竞争力方面还不如CEE地区的其他小国家,如匈牙利等。因此,目前波兰制药业正努力追赶,试图在国...
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ShouldProgestinsBeBlamedfortheFailureofHormoneReplacementTherapytoReduceCardiovascularEventsinRandomizedControlledTrials?
...roxyprogesteroneacetate(MPA)attenuatedtheeffectsofconjugatedequineestrogen(CEE)inincreasingHDLcholesterollevels.5WeobservedthatCEE0.625mgaloneorincombinationwithMPA2.5mgchangedtotalcholesterolandLDLcholesterollevelstoasimilarextent;however,HRTdidnotincreasetriglyceridelevelsandincreasedHDLcholestero...
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激素替代疗法与冠心病预防
...女,随机分为激素替代组和安慰剂组,分别服马雌激素(CEE)/MPA或安慰剂,平均随访4.1年。从1998年起公布结果,尽管CEE/MPA组血浆LDL-C下降11%,HDL-C上升10%(P值均0.001),但未能减少冠心病患者反复的心血管事件及死亡,所有冠心病...
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HDL的药物治疗
...atureHDLNascentHDLLDLRHLIntestineNIACINNIACIN**InhibitsuptakeofapoA-IbutnotCEExtended-ReleaseNiacinforTreatmentofDyslipidemia*Significantdifference(P0.001)betweendosagegroups.1.MorganJMetal.AmJCardiol1998;82(12A):29U–34U2.CapuzziDMetal.AmJCardiol1998;82(12A):74U–81U?Copyright1998,withpermissionf...
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ConjugatedEquineEstrogen,EsterifiedEstrogen,ProthromboticVariants,andtheRiskofVenousThrombosisinPostmenopausalWomen
【摘要】Background-Jointexposuretooralconjugatedequineestrogen(CEE)andprothromboticgeneticvariantsfactorIIG20210AorfactorVG1601A(Leiden)increasevenousthromboticrisk6-to16-foldinpostmenopausalwomen.Esterifiedestrogen(EE),analternativeestrogeniccompound,appearsnottobeassociatedwithincreasedriskand...
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EffectofLowerDosageofOralConjugatedEquineEstrogenonInflammatoryMarkersandEndothelialFunctioninHealthyPostmenopausalWomen
...domizedinto3groupstoreceivenotreatment(n=14)ororalconjugatedequineestrogen(CEE)atadosageof0.625mg(n=15)or0.3125mg(n=15)dailyfor3months.CEEatadosageof0.625mgresultedinsignificantincreasesinplasmaconcentrationsofCRPfrom690.9±749.5to1541.9±1608.0ng/mL,serumamyloidAfrom6.12±4.15to8.25±4.40μg/mL,and...
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尼尔雌醇
药物名称尼尔雌醇药物别名戊炔雌二醇,E3醚,Nylestriol,CEE3,Ethinylestriol-3-cyclopentyl Ether英文名称Nilestriol说 明片剂:每片1mg;2mg;5mg。功用作用是雌二醇衍生物,为口服长效雌激素。其口服雌激素活性为快雌醚的3倍,作用...
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EffectsofEstrogenReplacementTherapiesonMousePlateletFunctionandGlycoproteinVILevels
...sponsetoagonists.The3ERTregimesstudiedwere:(1)oralconjugatedequineestrogen(CEE),(2)oral17-estradiol(E2),and(3)subcutaneouslyimplantedE2(SQE2).Pairedovariectomizedlittermatesweretreatedwiththeseregimesorplacebofor21days.Twoplateletagonists,thrombinandtheGPVI-specificagonistcollagen-relatedpeptide(COL...
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炔雌醚
药物名称炔雌醚药物别名炔雌醇环戊醚,CEE,Estrovis,Ethinylestradiol-3-cyclopentylether英文名称Quinestrol说 明片剂:每片0.025mg;4mg。功用作用为作用较强的口服长效雌激素,其活性为炔雌醇的4倍。口服后贮存在体内脂肪中,并缓...
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RoleoftheEstrogenandProgestininHormonalReplacementTherapyonApolipoproteinA-IKineticsinPostmenopausalWomen
...andomized,crossoverstudycomprising3phases:placebo,conjugatedequineestrogen(CEE)(0.625mg/d),andCEEplusmedroxyprogesteroneacetate(MPA)(2.5mg/d).Comparedwithplacebo,treatmentwithCEEresultedinanincreaseinapoA-Ipoolsize(+20%,P0.01)becauseofasignificantincreaseinapoA-Iproductionrate(+47%,P0.05)andnosignif...
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EffectsofConventionalorLowerDosesofHormoneReplacementTherapyinPostmenopausalWomen
...eddose-dependentlyinpostmenopausalwomentreatedwithconjugatedequineestrogen(CEE)0.625and1.25mg.7Inthisregard,wereportedthatconventionaldosagesofCEE0.625mgincreasedtissuefactoractivityandF1+2,indicatorofcoagulationactivation,8,9andobservationalstudiesdemonstratedthattheriskforthromboembolismincreasesd...
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Estrogens,Progestins,andAtherosclerosis
...gonisticeffectsofmedroxyprogesteroneacetate(MPA)onconjugatedequineestrogen(CEE)-inducedpromotionofendothelium-dependentdilationinatheroscleroticmonkeys.TheauthorsalsofailtociteathirdstudyofWilliamsetal6showingthelackofanantagonisticeffectoftheprogestinnomegestrolacetate.Together,thesestudiescontradi...
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雌激素替代治疗女性压力性尿失禁
...经后妇女随机分为四组,分别给予雷洛昔芬、它莫西芬,CEE和安慰剂,20周后进行盆腔检查。对主诉尿失禁的妇女进行棉垫试验。雷洛昔芬和它莫西芬相对雌激素和安慰剂都能够使盆腔器官脱垂(pelvicorganprolapsed,POP)症状加重。...
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广州市天河区1162例患者高血脂检出率回顾性分析
...2):66~68. [2]沈文梅,王成彬,董振南,等.尼尔雌醇(CEE3)防治绝经妇女血脂紊乱的研究[J].老年医学与保健,1996,2(3):100. [3]宋文琪,杨浩洁.高级知识分子肥胖与血脂、脂肪肝关系探讨[J].安徽中医学院学报,2000...
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PreventionofCoronaryHyperreactivityinPreatherogenicMenopausalRhesusMonkeysbyTransdermalProgesterone
...ndindicatethatpostmenopausalHTusingacombinationofconjugatedequineestrogens(CEE)andmedroxyprogesteroneacetate(MPA)shouldnotbeusedforpreventionofcoronaryheartdisease(CHD)inwomenalreadyhavingCHD.3Furthermore,theWHIstudy,evaluatingthemostcommonlyusedHT(CEE+MPA)forchronicpreventionofdiseasesinhealthyPMW,...
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Estrogen:AMitochrondrialEnergizerThatKeepsonGoing
...nlyusedestrogeninanimalstudiesisE2,theWHIstudyusedconjugatedequineestrogen(CEE),whichisthemostcommonlyprescribedestrogenHTcomponentintheUnitedStates.CEEcontainsanumberofestrogenicsteroids,manyofwhicharesulfatedesters.SeveraloftheestrogenswithinCEEarenotwellcharacterizedintermsoftheirpharmacologyandt...
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枳实提取物中类黄酮的高效液相色谱法测定及其抗氧化作用研究
... 2.1枳实提取方法枳实提取物(C.aurantiumL.ethanolextract,CEE):枳实粉碎,以70%乙醇,料液比1∶30,温度80℃,回流提取3次,2h/次,合并滤液,60℃真空浓缩,冷冻干燥,得浅棕色粉末。 2.2枳实内黄酮的测定(HPLC法,芦丁、...
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杜仲叶醇提物预防去势大鼠骨质疏松症的实验研究
...置到4℃冰箱中保存备用。 1.2.2尼尔雌醇(nilestriol,CEE3),化学名3-环戊醚,北京四环制药二厂合格产品。 1.3主要试剂及仪器 RatELISAIL-6试剂盒由美国ENDOGEN试剂公司生产,中国科学院上海原子核研究所生产的雌二醇放...
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Nutritionandlowbirthweight:fromresearchtopractice
...on(16K):FIGURE1..Prevalenceoflowbirthweightindifferentregionsoftheworld(2).CEE,CentralandEasternEurope;CIS,CommonwealthofIndependentStates.Nevertheless,itisplausiblethatimprovementsmayhaveoccurredinsomeregions.Wehavemorereliabledataindicatingreductionsintheprevalenceofearlychildhoodmalnutritioninsom...
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Dietarysoycontainingphytoestrogensdoesnothavedetectableestrogeniceffectsonhepaticproteinsynthesisinpostmenopausalwomen
...freehormoneconcentrations.Oralestrogengivenfor6wk[conjugatedequineestrogen(CEE)dosesof0.15,0.3,0.625(standarddoseofhormonereplacementtherapy),and1.25mg]wasshowntoalterSHBG(detectableataCEEdoseof0.15mg),TBG(detectableataCEEdoseof0.3mg),andgonadotropinconcentrations,includingthoseofFSH(detectableataCE...
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Differentialutilizationofsystemicandenteralammoniaforureasynthesisincontrolsubjectsandornithinetranscarbamylasedeficiencycarriers
...finfusion.Viewlargerversion(15K):FIGURE1..Mean(±SD)ratiosoftracertotraceeduringthetimecourseofisotopicenrichmentsof[18O]or[13C]urea,[15N]ammonia,and[15N]urea(n=6pergenotypicgroup).,intragastricstudyincontrolsubjects;,intravenousstudyincontrolsubjects;,intragastricstudyinornithinetranscarb...
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Menopause,micronutrients,andhormonetherapy
...tincombinationusedintheWHI)andby33%forPremarin(theconjugatedequineestrogen[CEE]usedintheWHI)(11).Thetotalnumberofwomenforwhompostmenopausalestrogenwasprescribedrosefrom10millionin1995toapeakof15millionin2001,andfellbackto10millionin2003.TheWHIfindingswereforeshadowedbytheHeartandEstrogen/ProgestinRe...
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EnhancedEnzymeImmunoassaywithNegative-Gray-ZoneTestingComparedtoaSingleNucleicAcidAmplificationTechniqueforCommunity-BasedChlamydialScreening
...nespecimen,whichtheyreturnedbypostfortesting.Wetested1,003specimensbyIDEIAPCEEIA(Dako)andCobasPCR(Roche).Therewere32(3.2%)truepositivespecimensaccordingtoacombinedstandardusinganalgorithmrequiringconcordantresultsfromatleasttwoindependenttests.AllofthesewerepositivebyCobasPCRand24wereconfirmedtobepo...
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Inhibitionoftherenalbetainetransporterbycalciumions
...(Fig.11).BGT1abundancewasestimatedbydensitometryandexpressedrelativetosurfaceE-cadherinabundance,whichdidnotchange(Fig.10),andwasusedasaloadingcontrol(33).TheBGT1/cadherinratiodecreasedfrom1.95incontrolsto0.25inPMA-treatedcells.Fig.11.SurfacebiotinylationofintactcellsconfirmedlossofplasmamembraneBGT...
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VascularEndothelialGrowthFactorSynergisticallyEnhancesInductionofE-SelectinbyTumorNecrosisFactor-
...inedbysensitiveflowcytometry,althoughTNF-stronglyinducedCAMmRNAandcellsurfaceexpression.AdenoviraloverexpressionofVEGFalsohadnoeffectonendothelialVCAM-1andE-selectinexpressioninarabbitmodelofneointimaformationandneointimalmacrophageaccumulation.Surprisingly,whenHUVECswerepre-incubatedwithVEGFbeforeT...