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Optimizationofaselfantigenforpresentationofmultipleepitopesincancerimmunity
...ccurs,immunitycanbefurtherrestrictedbyadominantresponsedirectedatonlyasingleepitope.Enhancedantigenpresentationofmultipleepitopeswasinvestigatedasastrategytoovercomethesebarriers.Specificpointmutationsthatcreatealteredpeptideligandswereintroducedintothegeneencodinganonimmunogenictissueselfantigenexp...
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儿童嗜酸细胞性食管炎基因研究获进展
...人父母者可能都没有听说过这种名为嗜酸细胞性食管炎(EE)的疾病,这是一种炎症性疾病,往往(并不总是)因食管对食物过敏所引起,症状包括恶心、烧心、呕吐和吞咽困难,严重病例可出现营养不良,需要采用特殊的流质...
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瑞典普通成人人群中高发生率的胃食管反流症状以及存在和不存在症状的食管炎:一项Kalixanda研究报告
...行政区中成人胃食管反流症状(GERDS)和糜烂性食管炎(EE)的危险因素。来自2个瑞典行政区成人(20-81岁)人口(n=21610)的随机样本(n=3000)进行了有关胃肠道症状的邮件问卷调查,回复率为74%。最后随机邀请了部分回复者...
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中国研究者研究胃食管反流病与功能性消化不良、肠易激综合征症状重叠
...肠易激综合征(IBS)症状的发生率,分析糜烂性食管炎(EE)和非糜烂性反流病(NERD)亚型患者重叠FD、IBS症状发生率的异同。研究者通过胃镜及24h食管pH监测,将147例GERD患者区分为EE47例、病理性酸反流[NERDpH(+)]42例和生理...
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两种麻醉方式下上腹部手术患者围术期能量代谢和呼吸氧价变化的比较
...后手术中的氧耗量(VO2)、二氧化碳产生量(VCO2)、能量消耗(EE)均低于麻醉前,而呼吸商(RQ)高于麻醉前硬膜外阻滞复合全身麻醉组患者手术后VO2、VCO2、EE、RQ的变化无统计学意义;全凭静脉复合麻醉组患者手术后VO2、VCO2、EE均高于麻醉...
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胃食管反流病发病现状及治疗要点
...的最新进展。 GERD可分为内镜阳性的糜烂性食管炎(EE)和非糜烂性反流病(NERD)两种类型。据他介绍,过去我国GERD很少见,仅在近二十年来,GERD的发病逐渐增多。2000年我国学者潘国宗教授和许国铭教授的流行病学调查结...
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护士心身耗竭程度及对员工援助计划的需求调查
...采用Maslach编制的护士工作问卷(MBI),内容包括情绪枯竭(EE)、去人格化倾向(DP)、个人成就感(PA)3个因子和自编的护士对EAP的认知与需求调查问卷,对227名护理人员进行问卷调查。结果本组EE和DP因子均分处于中等程度,而PA因子均...
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激素替代对猴宫骶韧带和圆韧带生物力学特性的影响
...究了卵巢切除术(OVX)和共轭马雌激素加宫安黄体酮(CEE/MPA)或乙炔基雌二醇加炔诺酮(EE/NA)对绝经后(PMP)猴宫骶韧带(USL)及圆韧带(RL)生物力学特性的影响。在这项随机三盲安慰剂对照研究中,OVX猴分别接受12个月的CE...
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ICU护理人员心理健康状况相关因素分析
...5),而与学历水平差异无显著性(P>0.05),情感枯竭(EE)和去人格化倾向(DP)与SCL-90评分总分及各因子呈正相关;个人成就感(PA)与SCL-90评分总分及各因子呈负相关。结论影响ICU护理人员心理健康问题的因素包括专业技术...
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胃食管反流病的诊断
...提出将GERD分为非糜烂性食管炎(NERD)和糜烂性食管炎(EE),EE可进一步发展为BE。临床上诊断GERD方法很多,现综述如下。124h食管pH检测根据Johnson等[3]积分评定患者反流程度,将pH4%被认为有酸反流存在。卢雪峰等[4]实验...
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Energybalanceandtheaccuracyofreportedenergyintakeinpreadolescentchildrenwithcysticfibrosis
JillianTrabulsi1,JoanISchall1,RichardFIttenbach1,IreneEOlsen1,MarcYudkoff1,YevgenyDaikhin1,BabetteSZemel1andVirginiaAStallings11FromtheDivisionsofGastroenterologyandNutrition(JT,JIS,BSZ,andVAS),BiostatisticsandDataManagementCore(RFI),andChildDevelopmentandRehabilitationMedicine(MYandYD),TheChildren&...
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Predictorsofbodyfatgaininnonobesegirlswithafamilialpredispositiontoobesity
...rnment.3SupportedbyNIHgrantR29HD34029(toMST),theUSDA/ARSunderCooperativeAgreementno.6250-51000-023-00D/01(toMSTandNFB),andtheUniversityofMarylandGRECCandClaudeDPepperOlderAmericansIndependenceCenter(toJDS).4Reprintsnotavailable.AddresscorrespondencetoMSTreuth,CenterforHumanNutrition,JohnsHopkinsBloo...
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InhibitionofEstrogen-MediatedUterineGeneExpressionResponsesbyDioxin
...en-induceduterinegrowthandproliferation.Theinhibitionofestrogen-mediatedgeneexpressionthroughER/AhRcross-talkhasbeenproposedasaplausiblemechanism;however,onlyalimitednumberofinhibitedresponseshavebeeninvestigatedthatareunlikelytofullyaccountfortheantiuterotrophiceffectsofTCDD.Therefore,theeffectsofT...
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Longitudinalchangesintheaccuracyofreportedenergyintakeingirls1015yofage
...GB,AM,HC,JLS,andWHD);theDepartmentofHealthSciences,BostonUniversity(LGB);theEuniceKennedyShriverCenterattheUniversityofMassachusettsMedicalSchool,Waltham,MA(LGB);theDepartmentofFamilyMedicineandCommunityHealth,TuftsUniversitySchoolofMedicine,Boston(AM);theGeraldJandDorothyRFriedmanSchoolofNutritionS...
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Comparisonofenergyexpenditureestimatesfromdoublylabeledwater,aphysicalactivityquestionnaire,andphysicalactivityrecords
...EA).2MentionofatrademarkorproprietaryproductorservicedoesnotindicateguaranteeorwarrantyoftheproductorservicebytheUSDepartmentofAgricultureanddoesnotimplyitsapprovaltotheexclusionofotherproductsorservicesthatmayalsobesuitable.3AddressreprintrequeststoJMConway,USDepartmentofAgriculture/AgriculturalRes...
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Physicalactivityandweightloss:doesprescribinghigherphysicalactivitygoalsimproveoutcome?
...ofEpidemiology,UniversityofMinnesotaSchoolofPublicHealth,1300SouthSecondStreet,Suite300,Minneapolis,MN55454-1015.E-mail:jeffery{at}epi.umn.edu.ABSTRACTBackground:Recommendingincreasedphysicalactivityfacilitateslong-termweightloss,buttheoptimallevelofphysicalactivitytorecommendisunknown.Objective:The...
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重度血液稀释性贫血对犬机体和脑代谢的影响
...同时间点测量全身CO2产量(Vco2)、O2耗量(Vo2)、全身代谢率(EE),动脉和脑回流静脉血气、血糖、乳酸、血常规,计算脑动-静脉氧含量差(Da-jvO2)、乳酸含量差(Da-jvL)、脑氧摄取率(CEO2)、脑糖摄取率(Erglu),分析全身及脑代谢。结果在...
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Validationofenergyintakemeasurementsdeterminedfromobserver-recordedfoodrecordsandrecallmethodscomparedwiththedoublylabeledwatermethodinov
...idethecafeteria,24-hsnackrecallswereconductedbeforemeals.Energyexpenditure(EE)wasmeasuredwiththedoublylabeledwater(DLW)method(EEDLW).Energybalancewasdeterminedbymeasuringbodyweightatthebeginningandendofthe2-wkperiod.Results:ThemeanEIinthewomen(10.40±1.94MJ/d)andmen(14.37±3.21MJ/d)wasnotsig...
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ReplytoTMSWolever
...study,recentlypublishedintheJournal,concludedthatabstentionfromfilteredcoffeereducestheconcentrationsofplasmahomocysteineandserumcholesterol(1).Weconductedarandomizedprospectiveinterventionstudyorganizedasanunblindedcontrolledtrialwiththeparticipantsrandomlyassignedto3differenttreatmentgroupsthatwer...
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成都生物所新型手性配体的设计与手性反转控制研究获进展
...可以很好地控制产物的立体构型反转((S)-构型产物的ee值可达98%,(R)-构型产物的ee值可达99%)。这是该现象的首次报道,此研究将有助于有机合成工作者在手性反转控制研究领域进行更加深入的探索和研究。该研究结果近...
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Useofatriaxialaccelerometertovalidatereportedfoodintakes
...RACTBackground:Aneasyandcheapmethodforvalidatingreportedenergyintake(EI)isneeded.Objective:ReportedEIwascomparedwithcalculatedenergyexpenditure(EEcalc)andwithenergyexpendituremeasuredbythedoublylabeledwatermethod(EEDLW).Design:EEwascalculatedonthebasisofbasalmetabolicrate(BMR)measuredwiththeventilat...
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猴子研究表明孕激素对心血管损害有不同作用
...喂饲12个月)的作用:15只猴子没用激素,12只用炔雌醇(EE)加MPA,12只用EE加NETA。然后他们通过阻塞左前降支1小时评估了再灌注损伤,并采集了再灌注4小时后的心肌组织。MPA组左心室有不可逆心肌损害的比对照组更多(32%versus19%...
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Postprandialdenovolipogenesisandmetabolicchangesinducedbyahigh-carbohydrate,low-fatmealinleanandoverweightmen
...naftera17.5-hfast.Duringthefastingandpostprandialperiods,energyexpenditure(EE),macronutrientoxidation,diet-inducedthermogenesis,andseruminsulin,glucose,triacylglycerol,andfattyacidsweremeasured.TodetermineDNL,[1-13C]sodiumacetatewasinfusedandthemassisotopomerdistributionanalysismethodwasapplied.Resu...
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天津工生所ω-转氨酶研究取得新进展
...乙胺、(R)-1-苯丙胺、(R)-4-苯基-2-丁胺和(R)-α-四氢萘胺(ee值均大于99%)。与文献报道的只能以β-酮酸为底物合成β-氨基酸的ω-转氨酶不同,HBV能够以β-酮酸酯(如β-丁酮酸乙酯和β-戊酮酸乙酯)为底物不对称胺化生成β-氨基酸酯...
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MetabolicandbehavioralpredictorsofweightgaininHispanicchildren:theVivalaFamiliaStudy
...Sgovernment.3SupportedbyNIHgrantR01DK59264andtheUSDA/ARSundercooperativeagreement58-6250-51000-037.4AddressreprintrequeststoNFButte,Children‘sNutritionResearchCenter,1100BatesStreet,Houston,TX77030.E-mail:nbutte{at}bcm.edu.ABSTRACTBackground:DespitethehighprevalenceofoverweightamongHispanicchildre...
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Evaluationofaportabledevicetomeasuredailyenergyexpenditureinfree-livingadults
...lhoret{at}umontreal.ca.ABSTRACTBackground:Increasingdailyenergyexpenditure(EE)playsanimportantroleinthepreventionortreatmentofseverallifestyle-relateddiseases;however,itsmeasurementremainsproblematic.Objective:TheobjectivewastoevaluateaportablearmbanddeviceformeasuringdailyandphysicalactivityEEcompa...
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Therapeuticeffectsofdocosahexaenoicacidethylesterinpatientswithgeneralizedperoxisomaldisorders
...edwithagrantfromtheBiomedicalTestsMaterialsProgram(NIH/DOC),Bethesda,MD.SomeextraamountsofdocosahexaenoicacidethylesterwerekindlyprovidedbyHarimaChemicals(Japan)andPronovaBiocare(Norway).3AddressreprintrequeststoMMartinez,UnitforResearchinBiochemistryandMolecularBiology,Maternity-Children‘sHospita...
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失血过多时,雌性激素能救命
...。从那以后,Chaudry的合成雌激素在DARPA的帮助下变身成为EE-3-SO4(ethinylestradiol-3-sulfate)。一剂这样的药物能将老鼠和马的死亡延缓6个小时。Chaudry说:“人们遭受外伤后会出现水肿,因此如果我们能够将引起水肿的液体引回血液循...
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天津工业生物所单胺氧化酶研究取得新进展
...ine手性前体(R)-1,2,3,4-四氢-1-萘胺的合成,分离产率为76%,ee值大于99%。显示出该酶及其突变体在手性胺合成当中的应用潜力。虽然该酶及其突变体酶(M226A和L353M等)对一级胺底物表现出较高的立体选择性和底物广谱性,但是对大...
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Comparisonofenergyexpenditureestimatesfrom4physicalactivityquestionnaireswithdoublylabeledwaterestimatesinpostmenopausalwomen
...bir{at}mdanderson.org.ABSTRACTBackground:Physicalactivityenergyexpenditure(EE)isanimportantdeterminantofhealth,andepidemiologistshaveusedvariousmethods,suchasphysicalactivityandenergyintakerecallsandrecords,toestimateenergycost.However,mostepidemiologicstudieshavenotvalidatedthesemethodsagainstthedo...