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PulmonaryHypertension
...erstandingofthediseasewasfirstaddressedbyaconsensusconference(20).IdiopathicPAHisararedisease,affectingapproximatelyonlyoneinonemillionpersonsinthepopulation.Butitisacrueldisease,frequentlyaffectingotherwisenormalyoungwomenwithamediansurvivalof2.8yearswhenuntreated(21).Anepidemicofpulmonaryhypertens...
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SildenafilversusEndothelinReceptorAntagonistforPulmonaryHypertension(SERAPH)Study
...(Table1).AllwereinWHOfunctionalclassIIIandthemajorityofpatientshadidiopathicPAH.Thirteenpatientsassignedtosildenafiland12receivingbosentancompletedtheprotocolandprovideddataforgroupanalysis.OnepatientassignedtosildenafildiedsuddenlyduringWeek14oftreatment.ABNPlevelmeasuredinabloodsamplefromthispatie...
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RatrenalcorticalOAT1andOAT3exhibitgenderdifferencesdeterminedbybothandrogenstimulationandestrogeninhibition
...catedbyanarrowheadandanarrow,respectively.InadditiontothestudiesoftheclassicPAH-transportingproteinsOAT1andOAT3,wehavealsotriedtotestwhethergenderdifferencesattheproteinlevelexistforOAT2,whichtransportsPAHonlyweakly(36,37).Previously,itwasshownthattheexpressionofOAT2-relatedmRNAintheratkidneyisstron...
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肾血管性高血压
...检测(即尿量减少25%,尿肌酐增高25%,对氨马尿酸廓清率CPAH增高50%)其阳性率可提高到72%。Dean并建议收集3次尿标本作测定。若尿量减少、肌酐及PAH浓度增高,则亦可定为“阳性”,假阴性率可减至8%。㈣放射性核素的应用1.放...