MSH2–MSH6stimulatesDNApolymerase,suggestingaroleforA:Tmutationsinantibodygenes
...neratesmutationsatA:Tbasepairs,however,remainsunclear.ItappearstorequiretheMSH2–MSH6mismatchrepairheterodimerandDNApolymerase(pol),asmutationsofA:Taredecreasedinmiceandhumanslackingtheseproteins.Here,wedemonstratethattheseproteinsinteractphysicallyandfunctionally.First,weshowthatMSH2–MSH6bindsto...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第4期α-黑素细胞刺激素体外对星形胶质细胞产生NO和前炎性细胞因子的影响
...细胞因子 摘 要 目的:研究α-黑素细胞刺激素(α-MSH)对LPS诱导星形胶质细胞产生NO和前炎性细胞因子的影响,探讨α-MSH的抗炎作用机制。方法:分别用LPS或α-MSH+LPS处理体外培养的大鼠脑星形胶质细胞,用Griess试剂测定NO,以M...
合作平台;医学论文;临床医学与专科论文;检验医学[D-Trp8]--Melanocyte-StimulatingHormoneExhibitsAnti-InflammatoryEfficacyinMiceBearingaNonfunctionalMC1R(RecessiveYellowe/eMouse)
...escriptionoftheselectiveMC3Ragonist[D-Trp8]--melanocyte-stimulatinghormone(MSH)andoftherecessiveyellow(e/e)mouse,bearinganonfunctionalMC1R,therebyincrementingourknowledgeonthistopic.Culturingperitonealmacrophagesofrecessiveyellow(e/e)micewith[D-Trp8]--MSHledtoaccumulationofcAMP,indicatingMC3Rrecepto...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第12期Identifyingprotein–proteininteractionsinsomatichypermutation
...ortinthisissuethattheerror-proneDNApolymeraseisstimulatedbytheheterodimericMSH2–MSH6mismatchrepairrecognitioncomplex.Humansdeficientforpolymerase(pol)(2)ormicedeficientinMSH2–MSH6(3–6)showasignificantreductioninhypermutationatA:Tsites.Thisstudy,whichshowsafunctionalinteractionbetweenerror-pron...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第4期α促黑素细胞激素对横纹肌溶解所致急性肾衰竭大鼠肾有保护作用
...07年第23卷第9期中国研究者探讨了α促黑素细胞激素(α—MSH)是否能减轻甘油诱导横纹肌溶解所致急性。肾衰竭(ARF)大鼠。肾组织中炎性反应和对。肾损害的保护作用。研究者选取48只SD大鼠随机分4组:健康对照组:肌注生理...
行业资讯;临床快报;肾脏相关α促黑素细胞激素对横纹肌溶解所致急性肾衰竭大鼠肾的保护作用
...07年第23卷第9期中国研究者探讨了α促黑素细胞激素(α—MSH)是否能减轻甘油诱导横纹肌溶解所致急性。肾衰竭(ARF)大鼠。肾组织中炎性反应和对。肾损害的保护作用。研究者将48只SD大鼠随机分4组:健康对照组:肌注生理盐...
行业资讯;临床快报;肾脏相关基因组所调控跨损伤DNA合成新机制研究获进展
...化医疗实验室郭彩霞课题组首次发现,错配修复关键蛋白MSH2能调控细胞内紫外辐射损伤引发的TLS过程。利用免疫共沉淀结合质谱技术,研究人员发现MSH2与TLS聚合酶Kappa(Polκ)结合,并且MSH2还调控TLS聚合酶与紫外引发的受阻复制叉...
行业资讯;临床快报;遗传与基因组ContributionofDNApolymerasetoimmunoglobulingenehypermutationinthemouse
...rther.AlthoughthisG/CbiasedmutationprofileresemblesthatofmicedeficientintheMSH2orMSH6componentsofthemismatchrepaircomplex,theresidualA/Tmutagenesisofpol-deficientmicediffersmarkedly.Thissuggeststhat,intheabsenceofpol,theMSH2–MSH6complexisabletorecruitanotherDNApolymerasethatismoreaccurateatcopying...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第8期-MSHpreventsimpairmentinrenalfunctionanddysregulationofAQPsandNa-K-ATPaseinratswithbilateralureteralobstruction
...uatetheeffectsoftheanti-inflammatoryhormone-melanocyte-stimulatinghormone(-MSH)treatmentonrenalfunctionandexpressionofaquaporins(AQPs)andNa-K-ATPaseinthekidneyinresponseto24hofbilateralureteralobstruction(BUO)orreleaseofBUO(BUO-R).Inratswith24-hBUO,immunoblottingrevealedthatdownregulationofAQP2andAQ...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第3期α-黑素细胞刺激素对缺血再灌注损伤大鼠肠黏膜免疫功能的影响
...121-1237国内(重庆)一项研究探讨了α-黑素细胞刺激素(α-MSH)对缺血再灌注(I/R)损伤大鼠肠黏膜免疫屏障的保护作用及机制。采用大鼠小肠缺血45min再灌注模型,治疗组于再灌注5min内尾静脉注射α-MSH。于再灌注后2h用免疫放射法...
行业资讯;临床快报;药理学