Physiologicalsignificanceofhypotonicity-inducedregulatoryvolumedecrease:reductioninintracellularCl-concentrationactingasanintracellularsignal
...RVDiscausedbyactivationofionchannelsandtransporters,whichcauseeffluxesofK+,Cl-,andH2O,leadingtocellshrinkage.Recently,weshowedthathypotonicitystimulatedtransepithelialNa+reabsorptionviaelevationofepithelialNa+channel(-ENaC)expressioninrenalepitheliaA6cellsinanRVD-dependentmannerandthatreductionofint...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第5期第六节 体液钾钠氯测定及方法学评价
...学评价 占体重约5%的无机盐主要有Ca、Mg、K、Na、P和Cl,这六种无机元素约占体内无机盐总量的60%0-80%,主要存在于体液。 一、标本处理及含量变动的影响因素 体内所含元素约60种之多,作为定量检测无机元素主...
医源资料库;医源图书馆;教材类;临床生物化学InhibitionofENaCbyintracellularCl-inanMDCKclonewithhighENaCexpression
【摘要】WeexaminedtheeffectsofintracellularCl-concentration([Cl-]i)ontheepithelialNachannel(ENaC)inalineofMadin-Darbycaninekidney(MDCK)cells(FL-MDCK)withahighrateofNa+transportproducedbystableretroviraltransfectionwithrENaCsubunits(MorrisRGandSchaferJA.JGenPhysiol120:71-85,2002).TreatmentwithcAM...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第10期Themitochondrialoriginofpostischemicarrhythmias
...globalischemiafollowedbyreperfusion.Typicalelectrophysiologicalresponses,includingprogressiveAPshorteningfollowedbymembraneinexcitablityinischemiaandventricularfibrillationuponreperfusion,wereobservedincontrolhearts.TheseresponseswerereducedoreliminatedbytreatmentwiththemBzRantagonist4‘-chlorodiaz...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第12期CX3CR1DeficiencyConfersProtectionFromIntimalHyperplasiaAfterArterialInjury
...nthechemokinereceptorCX3CR1isassociatedwithprotectionfromvasculardiseasesincludingcoronaryarterydiseaseandinternalcarotidarteryocclusivedisease.WeinvestigatedthemechanismsbywhichCX3CR1maybeinvolvedbyevaluatingtheinflammatoryresponsetoarterialinjuryinCX3CR1-deficientanimals.MethodsandResults-Femorala...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第9期老年冠心病慢性心力衰竭并发电解质紊乱的临床特点
...年冠心病CHF病人电解质紊乱的发生率增加,入院时血Na+和Cl-水平降低,心功能Ⅳ级病人血Na+、Cl-水平低于正常值,但不同心功能分级CHF病人间血K+水平差异无统计学意义。在老年冠心病CHF并发电解质紊乱病人中,低Na+及低Na++低Cl-...
医源资料库;在线期刊;齐鲁医学杂志;2008年第23卷第5期Phosphatidylinositol3-KinaseeCAktPathwayPlaysaCriticalRoleinEarlyCardiomyogenesisbyRegulatingCanonicalWntSignaling
...e(PI3K)playsacriticalroleintheearlystageofcardiomyocytedifferentiationofP19CL6cells.WehereexaminedmolecularmechanismsofhowPI3Kisinvolvedincardiomyocytedifferentiation.DNAchipanalysisrevealedthatexpressionlevelsofWnt-3aweremarkedlyincreasedandthattheWnt/-cateninpathwaywasactivatedtemporallyduringthee...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第7期单分散非多孔交联聚甲基丙烯酸环氧丙酯微球作为亲和色谱载体的研究
...的一个问题。 本文利用交联聚甲基丙烯酸环氧丙酯(CL-PGMA)单分散、非多孔微球作为亲和载体,以胰蛋白酶抑制剂为配基,制备了胰蛋白酶抑制剂-CL-PGMA高效亲和色谱填料,考察了CL-PGMA作为生物大分子亲和色谱载体的适用性。...
药品天地;专业药学;实验技术;色谱技术;色谱论文心血管系统药理学
...+浓度和有机负离子A-浓度比膜外高,而细胞外的Na+浓度和Cl-浓度比膜内高。在这种情况下,K+和A-有向膜外扩散的趋势,而Na+和Cl-有向膜内扩散的趋势。但细胞膜在安静时,对K+的通透性较大,对Na+和Cl-的通透性很小,而对A-几乎...
医源资料库;医学文档库;心血管相关IonanddiureticspecificityofchimericproteinsbetweenapicalNa+-K+-2Cl-andNa+-Cl-cotransporters
【摘要】Themammaliankidneybumetanide-sensitiveNa+-K+-2Cl-andthiazide-sensitiveNa+-Cl-cotransportersarethemajorpathwaysforsaltreabsorptioninthethickascendinglimbofHenle‘sloopanddistalconvolutedtubule,respectively.Thesecotransportersserveasreceptorsfortheloop-andthiazide-typediuretics,andinactiv...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第9期