CriticalfunctionofBmx/Etkinischemia-mediatedarteriogenesisandangiogenesis
...constitutivelyactiveformofBmxundertheendothelialTie-2enhancer/promoter(Bmx-SK-Tgmice)tostudytheroleofBmxinischemia-mediatedarteriogenesis/angiogenesis.Inresponsetoischemia,Bmx-KOmicehadmarkedlyreduced,whereasBmx-SK-Tgmicehadenhanced,clinicalrecovery,limbperfusion,andischemicreservecapacitywhencompar...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第9期RenalexpressionandactivityofthegerminalcenterkinaseSK
...inkinases.ThisscreeningdemonstratedexpressionofaproteinkinaseconsistentwithSK2,agroupIIgerminalcenterkinaseandhomologofhumanSte20-likekinase(SLK).SK2mRNA,proteinexpression,andkinaseactivitywereincreasedinratfetalkidneyhomogenates(embryonicdays17-21)comparedwithadultcontrols.Inadultkidneyssubjectedto...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第1期UseofPhylogeneticandPhenotypicAnalysesToIdentifyNonhemolyticStreptococciIsolatedfromBacteremicPatients
...rposes,24typeand9referencestrainswereanalyzed:S.sanguinisstrainsATCC10556T/SK1,SK4,andSK36(S.sanguinisstrainwhosegenomeiscurrentlybeingsequencedatVirginiaCommonwealthUniversity;www.sanguinis.mic.vcu.edu);S.oralisstrainsNCTC11427T/SK23andSK34;S.gordoniistrainsATCC10558T/SK3andChallis/SK7;S.mitisstrai...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第12期载脂蛋白E在神经细胞中表达对细胞功能的影响
...时,探讨apoE4在AD发病中的相关机制。研究方法筛选转染SK-N-SH定位观察表达鉴定功能分析构建真核表达质粒重组pEGFP-apoE质粒酶切电泳图apoE3Query:321cgcaggcccggctgggcgcggacatggaggacgtgtgcggccgcctggtgcagtaccgcg380||||||||||||||||||||||||||||||||||||||||||||||...
医源资料库;医学文档库;心血管相关CentralEuropeanDobravaHantavirusIsolatefromaStripedFieldMouse(Apodemusagrarius)
InstituteofVirology,HelmutRuskaHaus,ChariteSchoolofMedicine,HumboldtUniversity,D-10098Berlin,GermanyInstituteofVirologyInstituteofZoology,SlovakAcademyofSciences,84206Bratislava,SlovakiaABSTRACTDobravavirus(DOBV)isahantavirusthatcauseshemorrhagicfeverwithrenalsyndrome(HFRS)inEurope.Itishostedbyatlea...
医源资料库;在线期刊;微生物临床杂志;2005年第43卷第6期InhibitoryGatingModulationofSmallConductanceCa2+-ActivatedK+ChannelsbytheSyntheticCompound(R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtyla
【关键词】InhibitoryGatingModulationSKchannelsaresmallconductanceCa2+-activatedK+channelsimportantforthecontrolofneuronalexcitability,thefinetuningoffiringpatterns,andtheregulationofsynapticmechanisms.TheclassicSKchannelpharmacologyhaslargelyfocusedonthepeptideapamin,whichactsextracellularlybya...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第11期Bmi-IsEssentialfortheTumorigenicityofNeuroblastomaCells
...eeoftheMedicalUniversityofOhio.CellCultureHumanneuroblastomacelllinesSHEP1,SK-N-AS,SK-N-F1,SK-N-DZ,andSK-N-SHweregrowninDulbecco??smodifiedEagle??smediumsupplementedwith10%fetalbovineserum(FBS);IMR32,SK-N-BE(2),BE(2)-C,SY5Y,andLA1C55Nina1:1mixtureofDulbecco??smodifiedEagle??smediumandHam??snutrientm...
医源资料库;在线期刊;美国病理学杂志;2007年第169卷第4期Incidenceofkeratitisofvaryingseverityamongcontactlenswearers
...ation29August2004ABSTRACTAim:Todeterminetheincidenceofnon-severekeratitis(NSK)andseverekeratitis(SK)amongwearersofcurrentgenerationcontactlenses.Methods:A12month,prospective,hospitalbasedepidemiologicalstudywasconductedbyexaminingallcontactlenswearerspresentingwithacornealinfiltrate/ulcertoahospital...
医源资料库;在线期刊;英国眼科学杂志;2005年第89卷第4期ReceptorRegulationofGeneExpressionofAxonGuidanceMolecules:ImplicationsforAdaptation
...s)andmodulationofaxonguidancemolecules,weinvestigatedwhetherGPCRactivityinaSK-N-MChumanneuroepitheliomacellline(whichexpresseslowlevelsofD1dopaminereceptors)affectsgeneexpressionofaxonguidancemolecules(semaphorins,ephrins,netrins,andtheirreceptors).Usingreal-timepolymerasechainreaction,weidentified1...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第7期EndothelialNitricOxideSynthaseActivationbyTumorNecrosisFactorThroughNeutralSphingomyelinase2,SphingosineKinase1,andSphingosine1PhosphateRe
...ialactivationofneutral-sphingomyelinase-2(N-SMase2)andsphingosine-kinase-1(SK1)andgenerationofsphingosine-1-phosphate(Sph1P).InhibitionofN-SMase2inhibitedSph1Pformation,whereasinhibitionofSK1didnotaffectN-SMase2activationbyTNF-.BlockadeofN-SMase2,SK1,ortheSph1PreceptorsS1P1andS1P3,eitherbysilencingo...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第1期