MatrixMetalloproteinaseInhibitorsSuppressTransformingGrowthFactor-ß-InducedSubcapsularCataractFormation
...fungizone(Invitrogen,Burlington,ON,Canada).Thefollowingday,lenseswereeitherleftuntreatedortreatedwithTGFß-2(R&DSystems,Minneapolis,MN)atafinalconcentrationof1or2ng/ml.Somelenseswereco-treatedwithTGFß-2andthebroadspectrumMMPinhibitorGM6001(Ilomastat)(ChemiconInternational,Temecula,CA)atco...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第1期四、近交系动物在免疫研究中的应用
...)阳性和抗核抗体阳性。 ⑶BXSB系 来自C57BL/6J×SB/leF1,H-2b,淋巴细胞表面同种抗原(Thy-1,2、TL-、Ly-1,2、Ly-2,1,Ly-3,1、Qa-1b),抗自身红细胞阳性,淋巴组织增生,B淋巴细胞增多。 ⑷MRL/1系 MRL/1小鼠是由C57BL/6J(H-2b)...
医源资料库;医源图书馆;教材类;医用实验动物学Caveolin-and-ßPerformNonredundantRolesinEarlyVertebrateDevelopment
...)resultedinafailuretorescuethecav-1morphantphenotype,verifyinganessentialroleforCav-1specificallyandimplicatingthisresidueinearlydevelopmentalfunctions.Cav-1and-1ßmorphantsalsoexhibiteddisruptionintheactincytoskeleton.TheseresultssupportimportantandpreviouslyunanticipatedrolesfortheCaveolin-1i...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第12期Flow-dependenttransportinamathematicalmodelofratproximaltubule
...inceHCO3-andH2CO3areinterconverted,massconservationrequires(14)for=IorE,whileforthetubulelumen,(15)Ineachcompartment(=I,E,orM),conservationoftotalCO2isexpressed(16)Correspondingtoconservationofprotonsistheequationforconservationofchargeforallthebufferreactions(17)whereziisthevalenceofspeciesi.Inthis...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第4期LineagespecificationandplasticityinCD19–earlyBcellprecursors
...numbersoftotalclonesinbothcontrolandDL1cultures.Thus,underconditionsfavorableforgeneratingBcells,Fr.AcangenerateTcellsifaNotch-1signalisprovided.IgheavychainrearrangementinitiatesveryearlyinBlineagedevelopmentWhileourRAG-2reporteranalysis(Fig.4B)indicatedthatRAGtranscriptionisalreadyactivatedinnearl...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第3期ActivationofNotch1signalingisrequiredfor?-catenin–mediatedhumanprimarymelanomaprogression
...ndmetastasis.Ourdatathereforesuggesta?-catenin–dependent,stage-specificroleforNotch1signalinginpromotingtheprogressionofprimarymelanoma.IntroductionNotchsignalingiscriticalfordevelopingandmaintainingtissuehomeostasis(1).Itspathwaycomprisesafamilyoftransmembranereceptorsandtheirligands,negativeandp...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第11期IL-2productionindevelopingTh1cellsisregulatedbyheterodimerizationofRelAandT-betandrequiresT-betserineresidue508
...esthataretypicalofthedifferentiatedstate.AlthoughthefactorsthatareresponsiblefortheearlyinductionofIL-2arewelldefined,themechanismsthatareresponsibleforitsdown-regulationinlaterstagesofThdevelopmenthavenotbeenstudiedasmuch.PreviousworkfromourlaboratoryrevealedarepressorfunctionfortheT-boxtranscripti...
医源资料库;在线期刊;实验医学杂志;2005年第202卷第9期Claudin-1regulatescellulartransformationandmetastaticbehaviorincoloncancer
...entifiedasaprobabletargetof?-catenin/Tcfsignaling,whichsupportsapotentialroleforclaudin-1dysregulationincolorectalcarcinogenesis(26).Basedonthesestudies,wehypothesizedthatclaudinshaveacausalroleintheprocessofcellulartransformationandinvasion.Inthepresentstudy,wereportincreasedexpressionofclaudin-1in...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第7期TheCriticalRolesofSerum/Glucocorticoid-RegulatedKinase(SGK)intheHairFollicleMorphogenesisandHomeostasis
...-----------------------------------------------------Themammalianhairfolliclefirstdevelopsfromembryonicectodermalhairgermbyreciprocalepithelial-mesenchymalinteraction1andthereaftermaintainsitsgrowthanddifferentiationduringtheprenatalandpostnatalperiods.Finally,likeotherorgansdevelopedfromanepithelia...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第4期