ß-Carotenerichorange-fleshedsweetpotatoimprovesthevitaminAstatusofprimaryschoolchildrenassessedwiththemodified-relative-dose-respon
...ntsourceofprovitaminA.Inmanydevelopingcountries,sweetpotatoisasecondarystaplefoodandmayplayaroleincontrollingvitaminAdeficiency.Objective:TheobjectivewastodeterminetheefficacyofdailyconsumptionofboiledandmashedOFSPinimprovingthevitaminAstatusofprimaryschoolchildren.Design:Childrenaged510ywerer...
医源资料库;在线期刊;美国临床营养学杂志;2005年81卷第5期傣中西医结合治疗类风湿关节炎的临床研究
...后每周增加55mg,直至每日2.0g。C、来氟米特(1eflunomide,LEF):剂量为10~20mg/日治疗。D、抗疟药(antimalarials):有氯喹和羟氯喹两种。其他药物还有青霉氨(D—peniciUamine)、金诺芬(au—ranofin)、硫唑嘌呤(azathioprin,AZA)、环孢素(cyclosp...
医源资料库;医学论文;中医中药;中西医结合NFATregulatescalcium-sensingreceptor-mediatedTNFproduction
...dwasinitiallycharacterizedasthereceptorexpressedonparathyroidcellsresponsibleformodulatingreleaseofparathyroidhormoneinresponsetochangesinplasmaionizedcalcium(4).However,theCaRisalsoexpressedinthekidney,brain,bone,gastricepithelialcells,andfibroblasts(20,39,41,45,48).ThusphysiologicalfunctionsoftheC...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第5期Actincytoskeletonregulatesextracellularmatrix-dependentsurvivalsignalsinglomerularepithelialcells
...trunculinBsequestersG-actinmonomers.InGEC,bothcompoundswereshowntodisassembleF-actinextensively(16).IncubationofGECwithcytochalasinDorlatrunculinBfor24hsignificantlyreducedERKactivationinparentalGEC,aswellasinR4F-MEK-andCD2-FAK-expressingclones,comparedwithuntreatedcells(Fig.1,A-C).Thusthereappearst...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第12期Cytokinesignaltransductionissuppressedinpreselectiondouble-positivethymocytesandrestoredbypositiveselection
...ivalofeitherDPpopulation,includingIL-7R+DPthymocytesfromIL-7RTgmice(Fig.2A,left),althoughexogenousIL-7diddramaticallyenhancetheinvitrosurvivaloflymphnodeTcells(LNTcells)fromIL-7RTgmice(Fig.2A,right).TounderstandIL-7‘sfailuretoenhancethesurvivalofIL-7R+DPthymocytes,weexaminedIL-7‘sabilitytoup-reg...
医源资料库;在线期刊;实验医学杂志;2006年第203卷第1期Gq-MediatedActivationofc-JunN-TerminalKinasebytheGastrin-ReleasingPeptide-PreferringBombesinReceptorIsInhibiteduponCostimulationoftheGs-Coup
...edifferentialinvolvementsofsignalingintermediates,GseemstoplayanimportantroleforbothGi,andGq-mediatedJNKactivationinresponsetostimulationofGPCRs.ReceptorscoupledtotheGsfamilyofGproteinsarecharacterizedbytheirabilitiestotriggeradenylylcyclase-mediatedcAMPformation(Balmforthetal.,1986).AmongallGPCRsth...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第5期Nothingbutskinandbone
...alroleinthebody’sdefensemechanism.Theskinanditsmanyappendagesareresponsibleforfunctionsasdiverseasepidermalbarrieranddefense,immunesurveillance,UVprotection,thermoregulation,sweating,lubrication,pigmentation,thesensationsofpainandtouch,and,importantly,theprotectionofvariousstemcellnichesintheskin....
医源资料库;在线期刊;临床研究杂志;2006年第116卷第5期InhibitionofSodiumChannelGatingbyTrappingtheDomainIIVoltageSensorwithProtoxinII
...andtherebyinhibitschannelactivation.Voltage-gatedsodiumchannelsareresponsiblefortheincreaseinsodiumpermeabilitythatinitiatesactionpotentialsinelectricallyexcitablecellsandarethemoleculartargetsforseveralgroupsofneurotoxinsthatbindtodifferentreceptorsitesandaltervoltage-dependentactivation,conductanc...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第3期BoneMorphogeneticProteinsinVascularCalcification
...atalthoughtreatmentofcommittedosteoblastprecursorswithBMP-7enhancedbonenoduleformation,treatmentactuallyinhibiteditinuncommittedcells.62Furthermore,treatmentwithBMP-7amonguncommittedcellsresultedinchondrocyteandadipocytedifferentiation.Similarly,othershaveshownBMP-2treatmentofC3H10T1/2pluripotentmes...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第7期ThemacrophageF4/80receptorisrequiredfortheinductionofantigen-specificefferentregulatoryTcellsinperipheraltolerance
...ivetransferofF4/80+APCsinbothperipheraltolerancemodels,indicatingacentralrolefortheF4/80moleculeinthegenerationofefferentCD8+Tregcells.Abbreviationsused:Ab,antibody;a.c.,anteriorchamber;ACAID,anteriorchamber–associatedimmunedeviation;BMAPCs,bonemarrow–derivedAPCs;DTH,delayed-typehypersensitivity...
医源资料库;在线期刊;实验医学杂志;2005年第201卷第10期