MelagatranReducesAdvancedAtheroscleroticLesionSizeandMayPromotePlaqueStabilityinApolipoproteinE-DeficientMice
...s,rinsed3xwithPBSandincubatedfor10minuteswithstreptavidinatroomtemperature.AEC-chromogensubstrate(Invitrogen,Karlsruhe,Germany)wasusedforvisualization.Finally,sectionswerecounterstainedwithhemalaun.Theextentofpositivestainingwithinthelesionswasdeterminedbytwoindependentinvestigatorswhowereblindedtot...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第12期Granulocyte-MacrophageColonyeCStimulatingFactorandLungImmunityinPulmonaryAlveolarProteinosis
...asextracellularproteinaceousmaterialandcelldebrismarkedlydecreased(Figures2AeC2Cand3A).AlthoughthepercentageofmacrophagesdecreasedinCase3aftertreatment,theabsolutenumberofmacrophagesin1mlofBALFincreased,forthesubstantialincreaseoftotalBALcells(Table1andFigure3A).Foamymacrophagesdecreasedaftertreatme...
医源资料库;在线期刊;美国呼吸和危急护理医学;2005年第171卷第5期LeptinPromotesVascularRemodelingandNeointimalGrowthinMice
...eradishperoxidaselabeled;Dako)followedbyincubationwithaminoethyl-carbazole(AEC)reagent(Zytomed),andmacrophageswereidentifiedwitharatanti-mouseMac-3antibody(PharMingen).OxidizedLDLwasdetectedwithanantibodyagainstmurinemalondialdehyde(MDA)-conjugatedLDL(akindgiftofDrW.Palinski,UniversityofCalifornia,S...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第1期GeneTransferofNeuronalNitricOxideSynthasetoCarotidBodyReversesEnhancedChemoreceptorFunctioninHeartFailureRabbits
...ivationandparasympatheticwithdrawalinheartfailure.JAmCollCardiol.1993;22:72AeC84A.EslerM,KayeD,LambertG,EslerD,JenningsG.Adrenergicnervoussysteminheartfailure.AmJCardiol.1997;80:7LeC14L.ZuckerIH,WangW,BrandleM,SchultzHD,PatelKP.Neuralregulationofsympatheticnerveactivityinheartfailure.ProgCardiovascD...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第8期Interleukin-17FInducesPulmonaryNeutrophiliaandAmplifiesAntigen-inducedAllergicResponse
...logicanalysisofairwayepitheliumstainedwithPASwasperformed.AsshowninFigures5AeC5E,histologicexaminationofthelungsrevealeddistinctdifferencesbetweendifferentgroupsofmice.AlthoughAg-sensitizedandAg-challengedmiceexhibitedPAS-positivemucouscellsinboththelargeandsmallairways,asignificantenhancementinthen...
医源资料库;在线期刊;美国呼吸和危急护理医学;2005年第171卷第1期TheRoleoftheMultidrugResistanceProtein-1inModulationofEndothelialCellOxidativeStress
...enter,EmoryUniversity.CellCulturePostconfluenthumanaorticendothelialcells(HAECs;Cambrex)betweenpassages4and10wereusedfortheexperiments.Cellsweremaintainedat5%CO2at37°Candpassagedevery6to10dayswhenconfluent.Cellswereexposedtoeitherunidirectionallaminarshear(15dyne)oroscillatoryshear(±15dyne)usingac...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第9期TheCXCL10/CXCR3AxisMediatesHumanLungMastCellMigrationtoAsthmaticAirwaySmoothMuscle
...eofsixsubjectswithasthmaandzeroofsixnormalcontrolsubjects(p=0.046)(Figures4AeC4C).CXCL12wasnotexpressedbyASMinthebronchialbiopsies,butwashighlyexpressedintheepitheliuminbothsubjectswithasthmaandnormalcontrolsubjects(Figures4Dand4E).AfteractivationwithTNF-,IFN-,andIL-1(10ng/mlofeach),theCXCR3ligandCX...
医源资料库;在线期刊;美国呼吸和危急护理医学;2005年第171卷第5期DifferencesinVascularBedDiseaseSusceptibilityReflectDifferencesinGeneExpressionResponsetoAtherogenicStimuli
...profilesofprimaryculturedECsfromhumansaphenousvein(SVEC)andcoronaryartery(CAEC)exposedtoatherogenicstimuli.Inadditiontoidentifyingdifferentiallyexpressedgenes,weappliedstatisticalanalysisofgeneontologyandpathwayannotationtermstoidentifysignalingdifferencesrelatedtocelltypeandstimulus.Differentialgen...
医源资料库;在线期刊;循环研究杂志;2006年第96卷第2期SpatialHeterogeneityofEndothelialPhenotypesCorrelatesWithSide-SpecificVulnerabilitytoCalcificationinNormalPorcineAorticValves
...ornigB,DrexlerH.Roleofoxidativestressinatherosclerosis.AmJCardiol.2003;91:7AeC11A.WungBS,ChengJJ,ShyueSK,WangDL.NOmodulatesmonocytechemotacticprotein-1expressioninendothelialcellsundercyclicstrain.ArteriosclerThrombVascBiol.2001;21:1941eC1947.MatsunagaT,HokariS,KoyamaI,HaradaT,KomodaT.NF-Bactivation...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第4期CollagenTripleHelixRepeatContaining1,aNovelSecretedProteininInjuredandDiseasedArteries,InhibitsCollagenExpressionandPromotesCellMigration
...ereperformedasdescribed.10Eitherdiaminobenzidineor3-amino-9-ethylcarbazole(AEC)wereusedtovisualizetheimmunoreactivity.Controlswithpreimmuneserum(1:1000dilution)fromthesamerabbitwereincludedforalltissuesections,andatthisdilution,nonspecificstainingwasnegligible.InSituHybridization35S-UTPeClabeledRNAp...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第2期