TheRoleof?-TransducinRepeat-ContainingProtein(?-TrCP)intheRegulationofNF-BinVascularSmoothMuscleCells
...ormallyrequiresaRINGfingerproteinforcatalyticactivity.TheE3proteinresponsibleforrecognizingthephosphorylatedmotifonIB(DS[PO3]GXS[PO3]),whererepresentsahydrophobicresidue)hasrecentlybeenidentifiedas?-TrCP/E3RS/Fwd1.14–16?-TrCPbindstolysineresidesonphosphorylatedIB,leadingtorecognitionbythe26Sprotea...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第1期Ikarostranscriptionfactors:flyingbetweenstressandinflammation
...dingprotein1;GATA-1,GATA-bindingprotein1;Hesx1,homeoboxexpressedinEScells1;Lef-1,lymphoid-enhancingfactor1;Lhx3,LIMhomeobox3;MEF,myeloidelf-1–likefactor;NFE2,nuclearfactorerythroid-derived2;Pax-5,pairedboxgene5;Pit1,POUdomain,class1,transcriptionfactor1;Pitx,paired-likehomeodomaintranscriptionfact...
医源资料库;在线期刊;临床研究杂志;2005年第115卷第4期围产期心肌病患者的预后探讨
...1PPCM患者的临床特点 注:EDD:心室舒张末期经线的长度;LEF:左心室的射血分数 所有的患者都是在分娩前,妊娠后期发现。发病至开始治疗的平均时间为1.5±0.8h。发病至胎儿分娩的平均时间为3.6±3.3天。其中5例患者采用剖宫产...
合作平台;在线期刊;中华实用医药杂志;2004年第4卷第15期;论著结肠癌组织中RON和β-catenin的表达及相关性研究
...变、肿瘤生长的主要原因。β-catenin是APC-β-cat-Tcf4/Lef信号转导通路的关键因子,其突变或异常表达可通过调控下游靶基因的复制与转录,参与大肠癌的发生及发展[1~4]。本实验旨在研究β-catenin及RON在结肠癌中表达,分析它...
医源资料库;在线期刊;中华现代外科学杂志;2010年第7卷第6期一起人畜共患炭疽疫情调查分析报告
...orthusepidemic.MethodsEpidemiologicalsurveyandanalysisonspot,collectthesamplefromsuspiciouspatientandlaboratoryexamination.ResultsFoundouttheinfectiousfocusandtransmissionchain,and3patientsappearedcutaneousanthrax,andgotBacillusanthraciswithtypicalbiologicalformthroughdirectsmearandbacteriumisolatio...
医源资料库;在线期刊;中华医学实践杂志;2006年第5卷第1期口腔遗传疾病的遗传方式及其临床表现
...almsandsoles-prematureperiodontaldestructionofteethsyndrome)又称Papillon-Lefèvre综合征(PLS),本病为常染色体隐性遗传,掌跖角化与角质素基因突变有关。有人称为类牙周炎变性病。临床表现:手掌和足跖部皮肤过度角化,多为弥漫型,早年...
医源资料库;在线期刊;中华医药杂志;2006年第6卷第12期TheMultipleLanguagesofEndothelialCell-to-CellCommunication
...tion.Thedefinitionofjunctionalmoleculesandtheircytoplasmicpartnersresponsiblefortriggeringintracellularsignalsisanissuenotyetcompletelyunderstood.1-5Ingeneral,signaltransductionbyjunctionalcomponentsissustainedanddirectedtoestablishhomeostasisofthecells.Thisdiffersfromthequickandshort-lastingactivat...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2006年第26卷第7期造血干细胞自我更新相关基因的研究进展
...究Wnt信号在体内内环境是否有活性,Reya等[14]用带GFP的LEF1/TCF(lymphoidenhancerfactor1/Tcellfactor,与βcatenin相互作用,促进靶基因转录)感染HSCs。将其移植入小鼠体内,他们分析表达GFP的HSCs,表明内源性干细胞可应答Wnt...
医源资料库;在线期刊;滨州医学院学报;2008年第31卷第2期PatternsandRiskFactorsforSystemicCalcifiedAtherosclerosis
...h-holdsathalf-maximalinspiration.Thecarotidandiliacbedscomprisedtherightandleftvesselsofeachofthosesegments.Thecoronaryvascularbedcomprisedtheleftmain,leftanteriordescending,leftcircumflex,andrightcoronaryarteries.Theproximalaorticbedwasdefinedasthesegmentfromtheaorticroottothediaphragm,whereasthedi...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第2期RegulationofbonemassbyWntsignaling
...deringopportunitiesforanabolicdrugdiscoveryinthisarea,onemustconsidermultiplefactors,including(a)therolesofWntsignalingfordevelopment,remodeling,andpathologyofbone;(b)howpharmacologicalinterventionsthattargetthispathwaymayspecificallytreatosteoporosisandotheraspectsofskeletalhealth;and(c)whetherthet...
医源资料库;在线期刊;临床研究杂志;2006年第116卷第5期