探索新路径——利用基因组学研究证候实质
...酶MspⅠ酶切分析。结果发现90例Wilson病患者有34例Arg778Leu/Gln点突变,Wilson病患者中医辨证分型属肝风内动者Arg778Leu/Gln点突变占20例,认为Arg778Leu/Gln点突变可能与中医肝风内动证型相关。 未来——深入研究基因与证候的内在关...
医学教育;科教新闻QuantitativeEvaluationofHumanOpioidReceptorDesensitizationUsingtheOperationalModelofDrugAction
...inescentkit(Pierce,Rockford,IL).SynthesisofaFluorescentDeltorphinIIAnalog.[Gln4]-deltorphin-rhodaminewassynthesizedbysolidphasesynthesisusingtheN-9-fluorenylmethoxycarbonylstrategy.[Gln4]deltorphin(Tyr-D-Ala-Phe-Gln-Val-Val-Gly)wasconjugatedtoafluorescentlabel,tetramethylrhodamineisothiocyanate(Mole...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第5期Immunologicevidenceofnoharmfuleffectofoatsinceliacdisease
...ohol-solubleproteinfractionsknownasprolamines.TheaminoacidsequencesPro-Ser-Gln-GlnandGln-Gln-Gln-Proareconsideredthetoxicfractionsoftheseprolamines.Atleastoneofthesesequencesexistsineachoftheabove-mentionedcereals(21).AlthoughthequestionofwhethertoincludeoatsinaGFDhasbeendebatedformanyyears,theeffec...
医源资料库;在线期刊;美国临床营养学杂志;2001年74卷第1期食管癌、贲门癌术后并发症的肠内营养支持治疗
...对免疫功能恢复作用优于TPN。可能机制是:EN为机体提供了Gln(谷氨酰胺)和Fb(膳食纤维),Gln是淋巴细胞、巨噬细胞的主要燃料,有较强的免疫恢复作用,Fb能促进肠上皮细胞合成和上皮细胞的更新[2]。总之,EN对机体营养...
合作平台;在线期刊;中华现代中西医杂志;2005年第3卷第11期;经验交流AnatypicalphenotypeofmacularandperipapillaryretinalatrophycausedbyamutationintheRP2gene
...hiftatcodon266,causingaprematurestopcodon,threeaminoacidsfurtherdownstream(Gln266fsTer269).Figure4Segregationofa4bpdeletionintheRP2genewithdisease.Electropherogramsdepictinga4bpdeletionintheRP2geneinaffectedmalesIII:2andIII:3(delCAGA).Wildtypesequenceisshowninthefather(II:2),andthecarriermother(II:1...
医源资料库;在线期刊;英国眼科学杂志;2004年第88卷第4期蚯蚓活性成分与应用研究进展
...W(即Val-Ile-Gly-Gly-Thr-Asn-Ala-Ser-Pro-Gly-Glu-Ile-Pro-Trp-Glu-Leu-Ser-Gln-Gln-Arg-Gln-Ser-Gly-Ser-Trp…)。e-PA可以切割碱性氨基酸、小的中性氨基酸及Met的羧基端,同时e-PA确能将纤溶酶原切割为纤溶酶。这一结论提示e-PA可能会发展成为新型溶栓...
合作平台;在线期刊;中华医学研究杂志;2004年第4卷第2期;综述DifferentialRegulationofHomocysteineTransportinVascularEndothelialandSmoothMuscleCells
...curringthroughasimilartransportsystem(s).SmallneutralaminoacidsCys,Ser,Tyr,Gln,Ala,Leu,andMet,ata100-foldhighermolarconcentration(1mmol/L)significantlyinhibitedthetransportofHcy(10.1µmol/L;Figure2).Cyswasthestrongestcompetitorwithsimilarcompetitivepotencyinbothcelltypes.CysreducedHcytransportt...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2007年第27卷第9期PharmacogeneticDifferencesinResponsetoAlbuterolbetweenPuertoRicansandMexicanswithAsthma
...NPseC654,eC47,+46,and+79andPre-FEV1andFEV1(Table4).AmongMexicans,glutamine(Gln)27wasmodestlyassociated(p=0.04)withFEV1(Table4).TherewerenosignificantassociationsbetweenindividualSNPsandIgElevelsineitherPuertoRicansorMexicans.Becausefamily-basedanalysessuggestedanassociationbetweenSNPsandbronchodilat...
医源资料库;在线期刊;美国呼吸和危急护理医学;2005年第171卷第3期肥胖相关基因的多态性与肥胖的关系
...现,主要定位在外显子2(Lys109Arg)、外显子4(Lys204Arg和Gln223Arg)和外显子12(Lys656Asn),密码子109,223,656的突变比较常见。Yiannakouris等[6]选择了118名脂肪百分比为肥胖者作为研究对象,检测了这3种多态,并同时测定患者的...
医源资料库;在线期刊;中国学校卫生;2007年第27卷第1期Thehumanorganicaniontransporter3(OAT3;SLC22A8):geneticvariationandfunctionalgenomics
...offunctionalheterogeneityamongOAT3variants,withthreevariants(p.Arg149Ser,p.Gln239Stop,andp.Ile260Arg)thatresultedincompletelossoffunction,andseveralotherswithsignificantlyreducedfunction.Oneofthemorecommonvariants(p.Ile305Phe),foundin3.5%ofAsian-Americans,appearedtohavealteredsubstratespecificity.Th...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第4期