Alteredexpressionofjunctionaladhesionmolecule4ininjuredpodocytes
...stages.Inthesestages,JAM4stainingwasbroadlydetectedalongthecellsurface(Fig.3Aa).AttheS-shaped-bodystage,JAM4stainingwasdetectedonthepresumptivepodocytesandthepresumptiveproximaltubules(Fig.3Bb).IncontrasttoJAM4,MAGI-1stainingwasnotdetectedintherenalvesicleorthecomma-shapedbody.MAGI-1wasfirstdetected...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第3期SLC26A7:abasolateralCl-/HCO3-exchangerspecifictointercalatedcellsoftheoutermedullarycollectingduct
...dney.AsshowninFig.3A(lowermagnificationx40),SLC26A7isabsentinthecortex(Fig.3Aa)butisabundantintheoutermedulla(Fig.3Ab).TodeterminethespecificityoftheSLC26A7antibodyinratkidney,labelingintheoutermedullawasexaminedwiththepreadsorbedimmuneserum.Asindicated,preadsorbedserumdidnotdetectanylabelingintheou...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第1期Inhibitionofwild-typep66ShcAinmesangialcellspreventsglycooxidant-dependentFOXO3aregulationandpromotesthesurvivalphenotype
...andabsenceofN-acetylcysteine(NAC;50µM).ThephosphorylationstatusofFOXO3aanditssubcellularlocalizationarecriticalforitstranscriptionalactivity(26,35).ThesitesofFOXO3aphosphorylationbyAkt/PKBhavebeenmappedtothreekeyregulatoryresidues(35).Inoursystem,wetestedThr-32,asiteonFOXO3aknowntobephosphoryl...
医源资料库;在线期刊;美国生理学杂志;2007年第290卷第2期Insulin-LikeGrowthFactor-BindingProtein-InducesPulmonaryFibrosisandTriggersMononuclearCellularInfiltration
...wninFigure3A,onday8Tcellswerethepredominantcelltypeinthealveolararea(Figure3Aa).SomescatteredBcells(Figure3Ab)andseveralmonocytes/macrophages(Figure3Ac)werealsoobservedaroundthevesselsatday8afteradenoviraladministration.Atday14,thenumberofTcellsdecreased(Figure3,AdandB)(104.80??39.95/HPFversus22.65?...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第11期ClC-5:roleinendocytosisintheproximaltubule
...quantifiedbymeasurementoffluorescenceintensitynormalizedpercell.ShowninFig.3Aa,bothWTandKOprimaryproximaltubularcellstakeupsignificantquantitiesofalbumin(green),althoughtheamountinKOcellswasvisuallymuchlessthanthatinWTcells.NotethatcellsculturedfromtheMCDCalsotakeupalbuminbutthereisnoapparentdiffere...
医源资料库;在线期刊;美国生理学杂志;2005年第288卷第8期Thrombomodulin-ProteinC-EPCRSystem
...ingexplored,withrecognitionofitsabilitytoinactivatethepotentanaphylatoxinsC3aandC5a33andtheproinflammatorymediatorsbradykininandosteopontin.34Thrombomodulin:Structure–FunctionItisjust20yearsagothatEsmonandOwenidentifiedandisolatedTM.35,36Sincethattime,steadyprogresshasbeenmadeinelucidatingthemolec...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第8期AnandamideInhibitionof5-HT3AReceptorsVarieswithReceptorDensityandDesensitization
...2001a)Associationbetweenthe5‘UTRvariantC178ToftheserotoninreceptorgeneHTR3Aandbipolaraffectivedisorder.Pharmacogenetics11:471-475.[CrossRef][Medline]NieslerB,WeissB,FischerC,NothenMM,ProppingP,BondyB,RietschelM,MaierW,AlbusM,FranzekE,etal.(2001b)SerotoninreceptorgeneHTR3Avariantsinschizophrenicand...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第2期关于公布第二批化学药品说明书目录的通知
...(15)255.复方氨基酸注射液(17AA)256.复方氨基酸注射液(3AA)257.复方氨基酸注射液(9AA)258.复方氨基酸注射液(l5AA)259.复方氨基乙磺酸滴眼液260.复方倍他米松注射液261.复方苯硝那敏片262.复方薄荷脑注射液263.复方地舍平片264....
医源资料库;医药卫生法规大全;药政类(药品、食品、器械);药品法规LimitedProtectiveEffectoftheCCR532/CCR532GenotypeonHumanImmunodeficiencyVirusInfectionIncidenceinaCohortofPatientswithHemophiliaandSelect
...thanclone238).Thepatient-derivedThaiHIVisolate,BK132,divergedfrompatient1by3aa(positions7,11,and25)andusedtheCXCR4receptor[54].WearecurrentlysubstitutingtheV3loopofawell-characterizedHIVclonewiththepatient1derivedV3looptofunctionallytestthetissuetropismoftherecombinant(A.K.N.I.andB.Chesebro,unpublis...
医源资料库;在线期刊;传染病学杂志;2003年第187卷第2期KineticsandregulationofaCa2+-activatedCl-conductanceinmouserenalinnermedullarycollectingductcells
...2+]iof10nM,noevidencefortheCaCCwasobtained,evenatlargepositivevoltages(Fig.3Aa).ThisdemonstratesthattheunderlyingCa2+-activatedCl-channelshaveanabsoluterequirementforintracellularCa2+toopen.Ata[Ca2+]iof100nM,wholecellcurrentswerealsoverysmall,butinaproportionofcells(6/13)slowoutwardcurrentrelaxation...
医源资料库;在线期刊;美国生理学杂志;2004年第287卷第4期