丁建平研究组CellResearch揭示调控新机制
...域三维结构的研究,发现其催化活性中心附近严格保守的Lys274残基发生了乙酰化修饰,并通过质谱进行了验证。生物化学和乙酰转移酶活性实验表明Lys274的乙酰化修饰是hMOF以分子内催化的方式进行的,而且这种自身乙酰化能促...
行业资讯;临床快报;细胞分子与蛋白质组InductionofvascularleakagethroughreleaseofbradykininandanovelkininbycysteineproteinasesfromStaphylococcusaureus
...ependenthypotension.ScpAandSspBtogetherinducedthereleaseofleucyl-methionyl-lysyl-BK,anovelkininwithVLandbloodpressure–loweringactivitiesthatareequivalenttoBK.Collectively,thesedatasuggestthatproductionofBKandleucyl-methionyl-lysyl-BKbystaphopainsisanewmechanismofS.aureusvirulenceandbacterialshock....
医源资料库;在线期刊;实验医学杂志;2005年第201卷第10期Contributionofintestinalmicrobiallysinetolysinehomeostasisisreducedinminipigsfedawheatglutenbaseddiet
...tges{at}fbn-dummerstorf.de.ABSTRACTBackground:Wepreviouslyreportedmicrobiallysinecontributiontoplasmalysinehomeostasisinhumanswithanadequatelysineintake.Objective:Wesoughttoexplorewhetherthelowlysineintakefromawheatglutenbaseddietisbalancedbyenhancedmicrobiallysinecontributioninapigmodel.Desig...
医源资料库;在线期刊;美国临床营养学杂志;2002年76卷第6期Heparin-BindingDomainsinVascularBiology
...d.6Amongthereasonsthatmakethistasksodifficultisthatheparinisapolydispersepolysaccharidewithaheterogeneoussaccharidesequencethatbindsalargenumberofproteins.Consequently,thereisawiderangeofpossiblebindingsitesalongtheheparinchainaswellasadiversityofheparin-bindingsitesamongthenumerousproteinsthatbindt...
医源资料库;在线期刊;动脉硬化血栓血管生物学杂志;2004年第24卷第9期12-1核被膜
...原,它在胞质中合成后很快积累在核中。其NLS为:pro-pro-lys-lys-lys-Arg-Lys-val,即使单个氨基酸被替换,亦失去作用。图12-7金标记的核质素穿越核孔 NLS由4-8个氨基酸组成,含有Pro、Lys和Arg。对其连接的蛋白质无特殊要求,并且...
医源资料库;医源图书馆;教材类;细胞生物学Aminoacidsasmodulatorsofendothelium-derivednitricoxide
...dedtotheperfusate.Theadditionof10-4or10-3Mcationicaminoacids(L-ornithine,L-lysine,orL-homoarginine)orneutralaminoacids(L-glutamine,L-leucine,orL-serine)totheperfusatedecreasedNOandincreasedrenalvascularresistance.Perfusionwithanionicaminoacids(L-glutamateorL-aspartate)hadnoeffectoneitherparameter.Th...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第8期微生物来源的具有促进纤溶作用的低分子化合物的研究进展
...flowmolecularweightcompoundsfromthemicrobialmetabolitesthatenhancingfibrinolysisWUWen-hui,BAOBin.DepartmentofMarinePharmaceuticalBiotechnologyCollegeofFoodScience,ShanghaiFisheriesUniversity,Shanghai200090,China【Abstract】Thepaperintroducesfibrinolyticsystem,structureandactivationofplasminogenw...
医源资料库;在线期刊;中华医学研究杂志;2006年第6卷第12期SLC4base(HCO3
...sport,andthespecificionsthataretransported,SLC4familymemberscanbeconvenientlyseparatedintothreefunctionalgroupswithpotentialtransportmodesforHCO3and/orCO32(Fig.1):1)Na+-independentCl/HCO3exchangersmediatingelectroneutralexchangeofClforbase(HCO3,CO32);2)Na+-HCO3cotransportersmediatingcotransportofNa+...
医源资料库;在线期刊;美国生理学杂志;2006年第289卷第2期清华大学生物化学试题(硕士)1998年-1996年
...哪种氨基酸溶液不使平面偏振光发生偏转(a)Pro(b)Gly(c)Leu(d)Lys()⒉对哺乳动物来说,下列哪种氨基酸是非必须氨基酸(a)Phe(b)Lys(c)Tyr(d)Met()⒊作为典型的催化剂酶具有下面哪种能量效应(a)降低反应的自由能(b)降低反应的活化能(c)...
医源资料库;医源习题集;生物化学南海海洋所揭示L-别异亮氨酸的生物合成机制
...希夫碱的形式形成PLP-L-Ile复合物;“氨基转移酶”MfnO的Lys206(或DsaD的Lys198)对PLP-L-Ile复合物中l-Ile的a碳位去质子化,形成醌式中间体复合物;异构酶MfnH的Arg107(或DsaE的Arg115)先对醌式中间体复合物的b碳位进行去质子化,形成...
医药经济;生物技术;技术要闻