Derivationoftolerableupperintakelevelsofnutrients
...umewithoutriskinghypercalcemia[itistheupperlimit,orthenoadverseeffectlevel(NOAEL)].“Although50µg/dforvitaminDwastheUL,itisimportanttorecognizethattheULisnotequivalenttotheNOAELof60µg/d.ThepurposeofthisletteristocorrectthismisconceptionbyclarifyingtheconceptsandterminologyusedintheDRIrevi...
医源资料库;在线期刊;美国临床营养学杂志;2001年74卷第6期ReplytoJHathcockandIMunro
...perintakelevel(UL)forvitaminDis17%lowerthanthenoobservedadverseeffectlevel(NOAEL).Thedistinctionwasomittedfromourarticle(1)forthesakeofbrevity,butitshouldhavebeenexplainedasHathcockandMunrodidintheirletters.Mycommentisthat,despitethetheoreticalprinciplesforderivingtheULforeachnutrient,theFoodandNutr...
医源资料库;在线期刊;美国临床营养学杂志;2001年74卷第6期TolerableupperintakelevelofvitaminD
...umewithoutriskinghypercalcemia[itistheupperlimit,orthenoadverseeffectlevel(NOAEL)].“Thisstatementiswronginspecificwaysthatshouldbecorrected.TheFoodandNutritionBoard(FNB)identifies50µg/dastheULforvitaminDformosthealthyadults(3).TheULisdefinedas“themaximumleveloftotalchronicdailyintakeofanutr...
医源资料库;在线期刊;美国临床营养学杂志;2001年74卷第6期RiskassessmentforvitaminD
...;g(13).TheFNBselected60µg(2400IU)astheno-observed-adverse-effectlevel(NOAEL)onthebasisofevidenceobtainedfromtheclinicaltrialofNarangetal(14)andselectedanuncertaintyfactor(UF)of1.2tocalculatethe50µgUL.Incontrast,intheirlaterreview,theSCFselected100µgfromtheresultsoftheclinicaltrialofVi...
医源资料库;在线期刊;美国临床营养学杂志;2007年85卷第1期肺动脉高压新药:“蓝嘴唇”的福音
...重复用药给药28天,恢复28天实验中,无毒性反应剂量(NOAEL)约为最大拟临床人用量的24倍。“预期临床每日只需口服一次(5~10mg片剂)就能用于PAH的治疗,并且不会与其它药物发生相互作用。”王震依据TPN171的良好药代动力学...
医药经济;生物技术;技术要闻Gastrointestinalsymptomsandbloodindicatorsofcopperloadinapparentlyhealthyadultsundergoingcontrolledcopperexposure
...rickMC,KlevayL,etal.DeterminationofanacuteNo-Observed-Adverse-Effect-Level(NOAEL)forcopperinwater.RegulToxicolPharmacol2001;34:13745.GonzálezM,TapiaL,AlvaradoM,TorneroJD,FernándezR.IntracellulardeterminationoftraceelementsbytotalreflectionX-rayfluorescencespectroscopyinmammalianc...
医源资料库;在线期刊;美国临床营养学杂志;2003年77卷第3期SafetyofvitaminD3inadultswithmultiplesclerosis
...ydetermininganintakethatfunctionedastheno-observable-adverse-effects-level(NOAEL)andthenadjustingthisleveldownwardbydividingtheNOAELbyanuncertaintyfactor(UF)(4).EvidencefromstudiesconductedsincetheestablishmentoftheULvaluesuggeststhatitismuchtoolow.Intakesof100µg/d(4000IU/d)(5)and250µg/d(1...
医源资料库;在线期刊;美国临床营养学杂志;2007年86卷第3期EfficacyandsafetyofvitaminD3intakeexceedingthelowestobservedadverseeffectlevel
...umewithoutriskinghypercalcemia[itistheupperlimit,orthenoadverseeffectlevel(NOAEL)].Aprolongedintakeof95µgvitaminD/dissaidtobethelowestobservedadverseeffectlevel(LOAEL),adosagethatcauseshypercalcemiainhealthyadults(1).Theseintakelimitshavechangedlittlefrompreviousguidelines(2).However,thecurrent...
医源资料库;在线期刊;美国临床营养学杂志;2001年73卷第2期VitaminsEandCaresafeacrossabroadrangeofintakes
...bledailyintakeinvolveidentificationofanintakethatisano-adverse-effectlevel(NOAEL)oralowest-adverse-effectlevel(LOAEL),evaluationofuncertainty,andcalculationofanintakethatisexpectedtocarrynosignificantriskofadverseeffects,ie,theULoracceptabledailyintake.TheULandacceptabledailyintakemethodsdiffermarke...
医源资料库;在线期刊;美国临床营养学杂志;2005年81卷第4期AssessmentofdietaryvitaminDrequirementsduringpregnancyandlactation
...eeffectlevel)wasonebyNarangetal(16).Thecurrentnoobservedadverseeffectlevel(NOAEL)of50µg/d(2000IU/d)isbasedonthefindingofNarangetalofameanserumcalciumconcentration11mg/dLinthe6“normal“subjectsgiven95µg(3800IU)vitaminD/d;thisintakebecametheLOAEL.ThenextlowesttestdoseusedbyNarangetal,60...
医源资料库;在线期刊;美国临床营养学杂志;2004年79卷第5期