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肾移植术中全身和肾脏血流动力学的变化
...n、1h记录血流动力学指标,开放后5min、30min时测量移植肾RBF。结果两组患者血流动力学变化趋势相近:与开放前相比,开放后5min时平均动脉压(MAP)和外周血管阻力降低,心输出量增加(P0.05),中心静脉压和心率保持稳定(P0.05...
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《相关文摘》:心肌康注射剂黄芪中间体指纹图谱的建立和人工神经网络的性能考察
...键词】XinjikangInjection;RadixAstragali;Intermediateproduct;Fingerprint;RBF-ANNS;【中文摘要】本论文分成两部分。第一部分为心肌康注射剂黄芪中间体指纹图谱的建立和方法学考察;心肌康注射剂是治疗病毒性心肌炎的有效中药复方制剂,由黄芪...
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cGMPstimulatesreninsecretioninvivobyinhibitingphosphodiesterase-
...esthetizedwithInactinbeforedeterminationofbloodpressure(BP),renalbloodflow(RBF),andsamplingofrenalvenousandarterialbloodtodetermineRSR.In13rats,basalBPwas104±2mmHg,RBFwas6.1ml·min-1·gkidneywt-1andRSRwas2.9±1.4ngANGI·h-1·min-1.InhibitingPDE-5with20mg/kgbodywt...
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EffectofendogenousangiotensinIIonthefrequencyresponseoftherenalvasculature
...lementsintherenalsympatheticnerveactivity(RSNA)signalintotherenalbloodflow(RBF)signalbutmarkedlyattenuatingthepassageofhigherfrequencyelements.Inapreviousstudy,therenalvascularfrequencyresponseofratswithcongestiveheartfailure(CHF)wasfoundtobeabnormal,withlittleattenuationoverthefrequencyrange0-0.6Hz...
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Effectofhaemodialysisonretinalcirculationinpatientswithendstagerenaldisease
...redchangesinvesseldiameterandbloodvelocityandcalculatedtheretinalbloodflow(RBF)intheretinalveinsinpatientswithESRDbeforeandafterhaemodialysisusingalaserDopplervelocimetrysystem.Inaddition,therelationsbetweenthechangesinsystemicandretinalcirculatoryparameterswereexamined.Results:Therewasagroupaverage...
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亨斯迈在美国得州建生物柴油装置
亨斯迈公司与生物柴油生产商RBF公司于2007年7月签署合同,将为亨斯迈公司在美国得州Neches港建设生物柴油装。装置一旦建成,由亨斯迈公司运营,由RBF公司向市场推销生物柴油。该装置初期生物柴油生产能力为8900万加仑/年,...
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Reducedautoregulatoryeffectivenessinadenosine1receptor-deficientmice
...A1AR-deficientmice(A1AR-/-),glomerularfiltrationrate(GFR)andrenalbloodflow(RBF)weredeterminedbeforeandafterreducingrenalperfusionpressurethroughasuprarenalaorticclamp.Inresponsetoabloodpressurereductionby15.9±1.34mmHginA1AR-/-(n=9)andby14.2±0.9mmHginA1AR+/+mice(n=8;P=0.31),GFRfellby187...
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急性心功能不全肾血流改变的超声造影评价
...在肾动脉主干上安置Doppler血流探头测量单侧肾血流量(RBF)。同时进行肾超声造影检查,测定肾微血管血流速度(β)、微血管容积(A)和微血管血流量(A×β)。应用超声造影探讨犬急性心功能不全肾血流变化。南方医科大学...
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Endothelialnitricoxidesynthase-deficientmiceexhibitincreasedsusceptibilitytoendotoxin-inducedacuterenalfailure
...0vs.157±18µl/min,n=9,P=notsignificant).However,renalbloodflow(RBF)wassignificantlydecreasedineNOSknockoutmicecomparedwiththewild-typecontrols(0.62±0.05ml/min,n=6vs.0.98±0.13ml/min,n=8,P0.05).Meanarterialpressure(MAP)wassignificantlyhigherineNOSknockoutmicethanthewild-typec...
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第三节 肾脏微循环的生理调节
...外。肾脏微循环具有高度的自动调节来维持总的肾血流(RBF)和肾小球滤过率(GFR)的稳定。当身体动脉压AP高于平均压10.64kPa(80mmHg)时,RBF和GFR均保持恒定。除动脉压改变外,静脉压上升,输尿管压力变化,以及血浆胶体渗透压...
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Effectsofhigh-resistant-starchbananaflour(RS2)oninvitrofermentationandthesmall-bowelexcretionofenergy,nutrients,andsterols:anileostomystu
...subjectswhoweregivenacontrolleddietwiththeadditionof30grawgreenbananaflour(RBF)/d,whichcontainsRS2,orcookedgreenbananaflour(CBF)/dinrandomorder.StudyBinvolved7ileostomysubjectswhoweregivenaplant-polysaccharide-freedietwiththeadditionof30gRBF/d.Results:InstudyA,thedryweightoftheileostomyeffluentsandt...
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Renal20-HETEinhibitionattenuateschangesinrenalhemodynamicsinducedbyL-NAMEtreatmentinpregnantrats
...kg1・day1iv).After4daysoftreatment,wemeasuredbloodpressure,renalbloodflow(RBF),renalvascularresistance(RVR),andglomerularfiltrationrate(GFR)ineachgroup.TheadditionofSNP(IC50=22μM)decreasedrenalcortical20-HETEproduction.Inpregnantrats,L-NAMEtreatmentledtosignificantlyhighermeanarterialpressure(MAP)...
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Glomerularandtubulardamageinnormotensiveandhypertensiverats
...obeensupportedbyarecentstudywherewefoundthatautoregulationofrenalbloodflow(RBF)waslesseffectiveinhypertensivethaninnormotensiveanimalsandlesseffectiveininnerthaninoutercortex,i.e.,patternsimilartothatseeninglomerulosclerosisandtubulardegeneration(27).Proteinuriahasbeensuggestedtobethemainpathogenicf...
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DualconstrictoranddilatoractionsofETBreceptorsintheratrenalmicrocirculation:interactionswithETAreceptors
...achreceptorclassaloneandtheirinteractions.ET-1(5pmol)reducedrenalbloodflow(RBF)25±1%.ETAantagonistBQ-123attenuatedthisresponsetoa15±1%decreaseinRBF(P0.01),indicatingnetconstrictionbyETBreceptors.Combinedreceptorblockade(BQ-123+BQ-788)resultedinarenalvasoconstrictionof7±1%(P=0.00...
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迪力(注射用肌苷冻干粉针)药效学研究综述
...术切除右肾并暴露左肾动脉总于置电磁探头测肾血流量(RBF),输尿管置输尿管导管收集尿液,动脉夹夹闭肾动脉总于lh造成IARF。18只动物随机分为3组并给下列3种药物中的1种:0.9%N·S6ml/kg(A,对照组)、AATP—MgCl230μmol/kg(B)、...
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耻骨上前列腺摘除术后合并急性肾功能衰竭4例报告
...卡那霉素所致?老年人肾功能减退主要表现在肾血流量(RBF)减少和肾小球血流量(GFR)减少,40岁以后每增加10岁RBF平均减少10%。此外40岁后随着年龄增加肾小动脉硬化,内膜增厚,管腔不规则与狭窄致使GFR减少。在老年人往往24...
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基于最小二乘支持向量机的色谱指纹谱预测银杏叶总抗氧化活性
...的支持向量机,常用的核函数有:线性核(LIN)、径向基核(RBF)和多项式核(POLY)。 2.2最小二乘支持向量机的参数优化 由式(8)和式(9)可知,LSSVM需要优化的参数包括γ和特定核函数的参数,如采用径向基核函数,模型参数为σ2...
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Furosemideincreaseswatercontentinrenaltissue
...eparatetheseeffects,itisimportanttomeasurepotentialchangesinrenalbloodflow(RBF)afterfurosemideadministration.NoninvasivemeasurementofbloodflowvelocityisperformedroutinelywithMRIusingaphasesubtractiontechniqueinwhichone-dimensionalvelocityencodingisgeneratedbyagradientechophase-contrastsequence(11).T...
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Comparisonofacuteandchronicantioxidantinterventionsinexperimentalrenovasculardisease
...tudiedexvivousingimmunoblottingandimmunohistochemistry.Basalrenalbloodflow(RBF)andglomerularfiltrationrateweresimilarlydecreasedinallRVDgroups.ACh-stimulatedRBFremainedunchangedinRVD,increasedinRVD+tempol,butfurtherincreased(similarlytonormal)inRVD+vitamins(P0.05vs.RVD).Furthermore,RVD+vitaminsalsos...
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IdentificationofaQTLonchromosome1forimpairedautoregulationofRBFinfawn-hoodedhypertensiverats
...epresentstudyevaluatedwhethertheimpairmentinautoregulationofrenalbloodflow(RBF)inthefawn-hoodedHypertensive(FHH)ratcolocalizeswiththeRf-1regiononchromosome1thathasbeenpreviouslylinkedtothedevelopmentofproteinuriainthisstrain.AutoregulationofRBFwasmeasuredinFHHandaconsomicstrain(FHH.1BN)inwhichchromo...
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Differentialeffectsofsaltonrenalhemodynamicsandpotentialpressuretransmissioninstroke-proneandstroke-resistantspontaneouslyhypertensiverats
...ontotherenalvascularbedintheSHRsp.“Step“and“dynamic“renalbloodflow(RBF)autoregulation(AR)wereexaminedin12-wk-oldSHRandSHRspafter35daysofan8%NaCldiet.DuringstepARunderanesthesia(n=811),RBFwassignificantlyhigherintheSHRspatallperfusionpressures(P<0.01),butARcapacitywasnotdifferent.Similarly,in...
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Evidencethatrenalarterial-venousoxygenshuntingcontributestodynamicregulationofrenaloxygenation
【摘要】Renalbloodflow(RBF)canbereducedinratsandrabbitsbyupto40%withoutsignificantchangesinrenaltissuePO2.WedeterminedwhetherthisoccursbecauserenaloxygenconsumptionchangeswithRBForduetosomeothermechanism.TherelationshipsbetweenRBFandrenalcorticalandmedullarytissuePO2andrenaloxygenmetabolismwered...
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EarlydiabetesasamodelfortestingtheregulationofjuxtaglomerularNOSI
...icNOSblockadehadnoadditionaleffectonNOSI-blockeddiabetics.2)Renalbloodflow(RBF)wasmonitoredforevidencethattubuloglomerularfeedback(TGF)resetsduring1hofcontinuousactivationwithbenzolamide.NOSIblockadewasaddedtotestfortheroleofNOSIinTGFresetting.During1hofTGFactivationincontrols,RBFinitiallydeclinedan...
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AcutedecreaseinrenalmicrovascularPO2duringacutenormovolemichemodilution
...tweenµPO2andPrvO2.Furthermore,therewasahighcorrelationbetweenO2renandRBFoverawiderangeofflows.Inconclusion,theoxygensupplytotherenaltissueisbecomingcriticalalreadyinanearlystageofANHduetothecombinationofincreasedO2ren,decreasedDO2ren,andintrarenalO2shunt.Thishasclinicalrelevanceasrecentpublica...
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肾移植围术期预充液体的观察
...间最短[4,5];CVP在移植肾动脉开放时,与肾血流量(RBF)呈正向相关关系,随着CVP的增加,RBF亦增加[1]。我们采用开放肾血流前预充胶体液的方法维持血压较高水平,血压维持在130~150/85~90mmHg以上,且高血压患者不能低...
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Roleofhemeoxygenase-1inendotoxemicacuterenalfailure
....64±2mmHg,P<0.01).Itwasfoundthattheinhibitorgrouphadhigherrenalbloodflows(RBF)alsoduringendotoxemia(1.8±0.2vs.0.68±0.1ml/min,P<0.01).Furthermore,whenrenalvascularresistance(RVR)wascalculated,therewasasignificantdecreaseinRVRintheinhibitorgroup(43.5±3.4vs.95.9±11.3mmHg・ml1・min1,P<0.01).Incon...
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Pentoxifyllineprotectsagainstendotoxin-inducedacuterenalfailureinmice
...ltissue,andtherenalarterieswereisolatedforthedeterminationofrenalbloodflow(RBF)usingabloodflowmeterandprobe(0.5v;TransonicSystems,Ithaca,NY)asdescribedbyTraynorandSchnermann(42).Meanarterialpressure(MAP)wasmeasuredviaacarotidarterycatheterconnectedtoaTranspacIVtransducerandmonitoredcontinuouslyusing...
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NO-independentmechanismmediatestempol-inducedrenalvasodilationinSHR
...weusedtheNOSinhibitorNw-nitro-L-argininemethylester(L-NAME).Renalbloodflow(RBF)andmeanarterialpressure(MAP)weremeasuredinvivobyelectromagneticflowmetryandarterialcatheterizationin10-to12-wk-oldanesthetizedSHRandSDrats.Systolicarterialpressure(SAP)wasmeasuredinconsciousratsusingthetailcuffmethod.Temp...
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Assessmentofrenalautoregulation
...ghlyefficientautoregulationsothatundersteady-stateconditionsrenalbloodflow(RBF)isindependentofbloodpressureoverawiderangeofpressure.Autoregulationoccursinthepreglomerularmicrocirculationandismediatedbytwo,perhapsthree,mechanisms.Thefastermyogenicmechanismandtheslowertubuloglomerularfeedbackcontribut...
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Kidneyoxygenconsumption,carbonicanhydrase,andprotonsecretion
...eneratepotentialenergyfortubularreabsorption(6,20,32,41).Therenalbloodflow(RBF)isnormallyhighrelativetothekidney‘sdemandforoxygen,sothekidneyextractsonlyasmallfractionoftheoxygenthatissuppliedtoit.However,duetocountercurrentexchangebetweenthearterialandvenouscirculations,thepartialpressureofoxygen...