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牡荆子提取物的保肝利胆作用研究
【摘要】目的研究牡荆子提取物(NCE)的保肝利用胆作用。方法给动物灌胃(ig)给药,用四氯化碳(CCl4)、醋氨酚(AAP)及消旋乙硫氨酸(DL-En)建立急性肝损模型,测定血清谷丙转氨酶(ALT)、谷草转氨酶(AST)水平及肝中...
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找准新药研发切入点
...裁王如伟—— 在化学药领域,目前最具创新价值的是NCE(Newchemicalentities,新化学实体)类的全新结构或机理的新药,但其开发周期往往在10年以上,投入和风险很大,但也极有可能会给企业带来很高回报。企业可根据自身的...
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Placentaltransport:afunctionofpermeabilityandperfusion
FrederickCBattaglia1FromtheUniversityofColoradoatDenverandHealthSciencesCenter,PerinatalResearchCenter,Aurora,CO2Presentedattheconference“MaternalNutritionandOptimalInfantFeedingPractices,“heldinHouston,TX,February2324,2006.3SupportedbyNationalInstitutesofHealthgrant5RO1HD034837-07,FetalVe...
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论《医疗事故处理条例》对医方的保护
...sionofhowthemedicalworkerbenefitfromthe《bylawforsettlingthemedicalnegligence》LiuQingchun,HaoReisheng,SongLixia.GeneralHospitalofChineseArmedPolice,Beijing100039.【Abstract】Thereactionaroseintenselyinthesocietyafterthe《bylawforsettlingthemedicalnegligence》wascarriedoutinSeptember,1...
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EstimatingHIVEvolutionaryPathwaysandtheGeneticBarriertoDrugResistance
...logne,Cologne,MaxPlanckInstituteofMolecularPlantPhysiology,GolmCenterofAdvancedEuropeanStudiesandResearch,Bonn,GermanyBackground.Theevolutionofdrug-resistantviruseschallengesthemanagementofhumanimmunodeficiencyvirus(HIV)infections.Understandingthisevolutionaryprocessisimportantforthedesignofeffectiv...
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高效液相色谱法测定高良姜中二苯基庚烷A的含量
...-hydroxyl-3“-methoxyphenyl)-1-pheny-3-heptanonefromAlpiniaofficinarumHance.MethodsTheHPLCwasusedtodeterminethecontentof5-hydroxyl-7-(4“-hydroxyl-3“-methoxyphenyl)-1-pheny-3-heptanonefromAlpiniaofficinarumHance,theanalysiswascarriedoutonEliteHypersilODS25μm(4.6mm×250mm),themobilephasewasAceto...
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Racial/ethnicconsiderationsinmakingrecommendationsforvitaminDforadultandelderlymenandwomen
...utritionResearchCenteronAging,TuftsUniversity,Boston.2Presentedattheconference“VitaminDandHealthinthe21stCentury:BoneandBeyond,“heldinBethesda,MD,October910,2003.3SupportedbytheUSDepartmentofAgriculture,underagreement58-1950-9001.Anyopinions,findings,conclusions,orrecommendationsexpressedi...
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TypingofNonencapsulatedHaemophilusStrainsbyRepetitive-ElementSequence-BasedPCRUsingIntergenicDyadSequences
...eBactériologie,CentreHospitalo-UniversitaireBretonneau,37044ToursCedex,FranceReceived17January2003/Returnedformodification26February2003/Accepted2May2003 ABSTRACTTopAbstractIntroductionMaterialsandMethodsResultsDiscussionReferencesIntergenicdyadsequences(IDS)areshortrepeatedelementsthathavebeende...
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Solutionsinweightcontrol:lessonsfromgastricsurgery
...essMedicalCenter,HarvardMedicalSchool,Boston2Presentedatthesymposium“Science-BasedSolutionstoObesity:WhatAretheRolesofAcademia,Government,Industry,andHealthCare?“,heldinBoston,MA,March1011,2004andAnaheim,CA,October2,2004.3SupportedbytheS.DanielAbrahamChairinNutritionMedicineatHarvardMedica...
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Copyrightprotectionandopenaccess
...rivatesector,physicians,andthepublic“(1).SoreadsHR2613,PublicAccesstoScience,abillbeforetheUSHouseofRepresentativesthatissponsoredbyRepresentativeMartinSaboofMinnesotaandthat,ifenacted,wouldplaceallpublishedworkthatis“substantiallyfunded“byagenciesoftheUSgovernment“beyondthereachofcopyrightp...
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青海省2001~2005年5岁以下儿童死因分析
...alysisofdeathcauseunderfiveyearoldchildrenin2001~2005inQinghaiprovinceSUNChunling,LIUXueli,YANGHua,etal.MaternalandChildrenHealthCareHospitalofQinghaiProvince,Xining810007,China【Abstract】ObjectiveTounderstandthemortalityofchildagedunder5yearoldandinfluentialfactors.Providings...
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PurificationofEnterocytozoonbieneusifromStoolsandProductionofSpecificAntibodies
...cpolyclonalantibodiesraisedinmiceandrabbitsreactedbyindirectimmunofluorescencewithE.bieneusibutnotwithEncephalitozoonspp.,Candidaalbicans,Staphylococcusaureus,Escherichiacoli,orotherformspresentinhumanstools.INTRODUCTIONEnterocytozoonbieneusiisawidespreadentericmicrosporidiumwhichprobablyinfectsmost...
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HIV-1DrugResistance:DegreeofUnderestimationbyaCross-SectionalversusaLongitudinalTestingApproach
BritishColumbiaCentreforExcellenceinHIV/AIDS,St.Paul‘sHospitalDepartmentofMedicine,UniversityofBritishColumbia,Vancouver,BritishColumbia,CanadaAIDSandViralHepatitisStudyGroup,DepartmentofInternalMedicine,VirgendelRocioUniversityHospital,Seville,SpainGenotypingofhumanimmunodeficiencyvirustype1(HIV-...
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NasopharyngealCarriageofPneumococcalPediatricSerotypes:ARiskforAcuteandRecurrentOtitisMediainChildrenandforInvasiveDiseaseinSusceptibleA
...nofspontaneousmutantsharboredinsmallnumbersamongthesusceptiblefloraorbyenhancementoftheproportionofpreexistingresistantstrainsinthecarriedpopulation[79].Thus,isolatesfromboththenasopharynxandthemiddleearinpatientswithrecurrentotitismediashowincreasedantibioticresistance[10].Fluoroquinolonesareusedto...
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Glaucoma.3rded.
...Butterworth-Heinemann,2004,ISBN0750655283.Thisexcellenttexthasbeeninprintsince1989anditslongevityistestamenttoitshighquality.Thisisthethirdedition,withanewco-authorJohnSalmon.Sinceitspreviouseditionover8yearsagotherehavebeenmanyadvancesinboththegenetics,andthediagnosis,monitoringandtreatmentofglauco...
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国外利用等位基因研究出检测杂草抗药性新技术
... 【原文】 CHEAPANDEFFECTIVETECHNIQUETODETECTHERBICIDE-RESISTANCE Whenherbicidesareregularlyappliedtoafield,someweedsdevelopherbicide-resistance,oneofthemajorthreatstoconventionalagriculturalpractices.Morethan305typesofweedinmorethan50countrieshavebeenreportedtoberesistanttoatleast...
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美研究发现:血糖会影响个体自我控制能力
...费,致使后续的自控更为困难。(CurrentDirectionsinPsychologiScience2007,16:351) 研究者令受试者执行Stroop测验,测试其自控的强度。受试者在任务中看到的是色词(如绘上蓝色的“红”字)。他们要说出词的色彩,而非词本身。研究者发现,...
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ClinicalSportsNutrition
...ssionalPublishing,NewYork.:CAlanTitchenalHumanNutrition,FoodandAnimalSciencesUniversityofHawaiiatManoa1955East-WestRoadHonolulu,HI96822E-mail:titch{at}hawaii.eduThisbookpresentsacomplementaryinterminglingofthescientificbasisandpracticalapplicationofsportsnutrition.Asasecondedition,itisalmost300pag...
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EssentialsofHumanNutrition
...ednutritiontextdesignedasastudentsintroductiontonutritionandasareferenceonbasicnutritionandnutritionprinciplesforphysiciansandotherhealthprofessionals.Althoughthebookcontainsmanyreferencesto2001publications,somesectionsarenoticeablyoutdatedbecauseofmorerecentlypublishedinformation.Specifically...
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FunctionalFoodsNutraceuticalsinCancerPrevention,
...ludessomegoodinformationculledfromanexpandingbaseofresearchonnutritionandcancerpreventionbutfailstoorganizethisinformationadequately.Inabriefintroductionbytheeditor,varioustermsforfunctionalfoods,suchasdietaryvegetables,dietarysupplements,andnutraceuticals,areusedbutnotadequatelyexplained.Thisfailur...
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MolecularNutrition
...t20y,theintroductionofpowerfulnewmoleculartechniqueshasmadeitpossibletoadvanceknowledgeinhumanbiology.Areductionistapproachisusedinmostdisciplines,butinnutrition,anintegrationistapproachisneededtodealwiththecomplexityofthesubject.Thisbooksuccessfullypresentsapproachesinmolecularnutritionthatillustra...
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ReplytoTJColeetal
...study(1).AlthoughthiswouldhaveimprovedthecomparativeresultsfortheIOTFreference,webelievethatachildabovethe95thpercentileforpercentagebodyfatshouldbeidentifiedasobese,becauseeventhisdegreeofadiposityisassociatedwithahighriskforthemetabolicsyndromeandbiomarkersofadversecardiovascularoutcomes(2).ACKNOW...
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NutritionalandClinicalManagementofChronicConditionsandDiseases
...ptheessentialsofdiagnosingandtreatingthiscondition.Alistofwebsitesforreferenceisaspecialfeatureofthischapter.Thesecondchapterisaboutadultobesityandisaconcisebutusefulchapterthatdiscussesdifferentdietaryapproaches.However,itlackssignificantinformationabouttheroleofexerciseintreatingobesityanditseffec...
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ReplytoSHowieetal
...bly;forexample,somecasedefinitionsincludewheezing,fever,C-reactiveproteinconcentrations,andchestX-rayfindings,whereasothersdonot.Howieetalstatethatbronchiolitiscasesareoftenmisdiagnosedaspneumonia,whichimpliesthatwheezingisafindingthatisnotconsistentwiththediagnosisofpneumonia.Weagreethatbronchiolit...
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ReplytoEVosetal
...attyacidsonclinicalcardiovascularoutcomesinhumansandevaluatedavailableevidenceaccordingtopredefinedquestions.Tominimizebias,conclusionsweredrawnbasedonthestudiesthatmetpredefinedcriteria.Vosetaldidnotdisagreewiththecriteriaweusedtodeterminethequalityofevidence.However,theyseemtodifferinwhattheywould...
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对不同平衡缺失进行平衡评价系统测验
...制系统进行临床平衡评价工具,平衡评价系统测验(BalanceEvaluationSystemsTest,BESTest)。BESTest由36个分项,组成6组:生物力学限制、稳定局限/垂直性、预订姿势调整、姿势反应、方位觉、步态稳定。在两个相互进行的研究中,19名...
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日本研究出人造纤维可“清理”血液尿毒症毒素
...来自日本国家材料科学研究所(NationalInstituteforMaterialsScience)的研究人员开发出了一种人造纤维,能够吸附肾衰竭患者血液中所含的尿毒症毒素肌酐,这一成果已经刊登在新一期《生物材料科学》(BiomaterialsScience)杂志上,将有助于...
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VitaminDsupplementationfornon-Westernpregnantwomen:theBritishexperience
...regnantnon-WesternwomenintheNetherlands.WewouldliketosharetheBritishexperienceandwillmainlydiscuss2aspectsoftheissue.First,wewilladdressevidenceofvitaminDdeficiencyinpregnantAsianwomenintheUnitedKingdomandthebenefitofroutineantenatalsupplementation.Second,wewilldiscusstheconfusionthathasarisenfromco...
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ReplytoCoenetal.
...umbiaUniversity,NewYork,NewYorkWeprovideadditionalinformationtoaddresstheconcernsraisedbyCoenetal.[1]aboutourarticle[2].Ourenumeratedanswerstothequestionsconcerningstudymethodologyarefollowedbyourresponsetothequestionsregardingthemathematicalmodel.1.Weselected3coloniespersampleasourinitialsamplenumb...
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TargetedTransgenicOverexpressionofMitochondrialThymidineKinase(TK)AltersMitochondrialDNA(mtDNA)andMitochondrialPolypeptideAbundance
...osphorylationseemstocorrelatewithmitochondrialtoxicity,butexperimentalevidenceislacking.Transgenicmice(TGs)withcardiacoverexpressionofthymidinekinaseisoforms(mitochondrialTK2andcytoplasmicTK1)wereusedtostudyNRTImitochondrialtoxicity.Echocardiographyandnuclearmagneticresonanceimagingdefinedcardiacper...